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Study · In vitro (cells) · mouse · 1983

4 results

In vitro modulation of mouse natural killer (NK) cell activity by the serum thymic factor (FTS).

Kaiserlian D, Bardos P, Bach JF

Cellular immunology1 Mar 1983Cited by 10 (Europe PMC)

PMID6682352 (opens in a new tab)DOI10.1016/0008-8749(83)90366-0 (opens in a new tab)PepBankPUB-06682352
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In mouse splenic cells, FTS increased or decreased NK cytotoxicity depending on age and strain.

    In plain wordsIn mouse cells, FTS increased or decreased natural killer activity depending on age and strain.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    MixedSplenic NK cell cytotoxicity
    Study

    mousen: not reported in source

    Mouse splenic effector cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The regulatory effects of FTS result in an increase or a decrease of the splenic NK cell cytotoxicity depending upon the age and the mouse strain.
    1 context sentence
    Summary · context
    The present report shows that such an effect is also observed after a short term in vitro incubation of the effector cells with FTS.
  2. 02LabIn vitro (cells)Mechanism

    In mouse thymus cells, FTS enhanced NK cell activity.

    In plain wordsIn mouse cells from the thymus, FTS increased natural killer activity.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseThymic NK cell activity
    Study

    mousen: not reported in source

    Mouse thymus cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, FTS is able to enhance the NK cell activity of thymus and bone marrow cells which are known to be weakly reactive in NK cytotoxicity.
    1 context sentence
    Summary · context
    The present report shows that such an effect is also observed after a short term in vitro incubation of the effector cells with FTS.
  3. 03LabIn vitro (cells)Mechanism

    In mouse bone marrow cells, FTS enhanced NK cell activity.

    In plain wordsIn mouse bone marrow cells, FTS increased natural killer activity.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseBone marrow NK cell activity
    Study

    mousen: not reported in source

    Mouse bone marrow cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, FTS is able to enhance the NK cell activity of thymus and bone marrow cells which are known to be weakly reactive in NK cytotoxicity.
    1 context sentence
    Summary · context
    The present report shows that such an effect is also observed after a short term in vitro incubation of the effector cells with FTS.
  4. 04LabIn vitro (cells)Mechanism

    In mouse cell depletion experiments, neither Thy 1+ cells nor macrophages mediated the FTS-induced increase in NK activity.

    In plain wordsIn mouse cells, neither Thy 1+ cells nor macrophages mediated the increase in natural killer activity after FTS.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    Not applicableMediation of NK activity increase
    Study

    mousen: not reported in source

    Mouse effector cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Depletion experiments demonstrated that the FTS-induced increase of NK cell activity was not mediated by Thy 1+ cells nor macrophages, thus suggesting a direct action of FTS on the effector cells.
    1 context sentence
    Summary · context
    The present report shows that such an effect is also observed after a short term in vitro incubation of the effector cells with FTS.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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