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Study · Animal study (in vivo) · 1983

7 results

Relationship between a spleen-derived immunosuppressive peptide 'SDIP' and the 'Facteur thymique sérique' (FTS): biochemical and biological comparison of the two factors.

Lenfant M, Millerioux L, Blazsek I, Duchange N

Immunology1 Apr 1983

PMID6682089 (opens in a new tab)PepBankPUB-06682089
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In an in vivo humoral immunity assay, FTS inhibited 19S-bearing cell formation during the final stage of lymphocyte differentiation.

    In plain wordsIn animals, FTS reduced formation of cells bearing 19S during the final stage of lymphocyte development.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    Decrease19S-bearing cell formation in vivo
    Study

    n: not reported in source

    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    As SDIP, FTS inhibited in vivo and in vitro the 19S-bearing cell formation during the last step of the differentiation of the lymphocytes, in the same range of concentration.
    1 context sentence
    Summary · context
    In order to compare the thymic hormone to SDIP the biological activity of FTS was determined in in vivo and in in vitro humoral immunity reactions to a T-dependent antigen.
  2. 02LabIn vitro (cells)Mechanism

    In vitro, FTS inhibited 19S-bearing cell formation during the final stage of lymphocyte differentiation.

    In plain wordsIn cells, FTS reduced formation of cells bearing 19S during the final stage of lymphocyte development.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    Decrease19S-bearing cell formation in vitro
    Study

    n: not reported in source

    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    As SDIP, FTS inhibited in vivo and in vitro the 19S-bearing cell formation during the last step of the differentiation of the lymphocytes, in the same range of concentration.
    1 context sentence
    Summary · context
    In order to compare the thymic hormone to SDIP the biological activity of FTS was determined in in vivo and in in vitro humoral immunity reactions to a T-dependent antigen.
  3. 03LabIn vitro (cells)Mechanism

    In short-term thymocyte cultures, FTS appeared to stimulate thymidine incorporation into DNA.

    In plain wordsIn cells, FTS appeared to increase thymidine incorporation into DNA.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseThymidine incorporation into DNA
    Study

    n: not reported in source

    Short-term thymocyte cultures
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The two factors appeared to stimulate the incorporation of [3H]-thymidine into the DNA of short-term cultures of thymocytes.

Studies that did not test the peptide alone4

In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymulin (serum thymic factor).

  1. 04LabNot a test of Thymulin (serum thymic factor) aloneIn vitro (cells)Activity measurement

    In sheep cell rosette tests, SDIP activity was similar to FTS activity.

    In plain wordsIn lab tests, SDIP and FTS had similar activity in sheep cell rosettes.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changeSheep cell rosette activity
    Study

    n: not reported in source

    Comparator
    SDIP
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    When tested in sheep cell rosettes, and in the FTS radioimmunoassay in J.F. Bach's laboratory, SDIP presented an activity similar to FTS.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  2. 05LabNot a test of Thymulin (serum thymic factor) aloneIn vitro (cell-free)Activity measurement

    In lab comparisons, FTS and SDIP had similar physicochemical properties and enzymatic susceptibilities.

    In plain wordsIn lab tests, FTS and SDIP had similar physical properties and responses to enzymes.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    Not applicablePhysicochemical and enzymatic properties
    Study

    n: not reported in source

    Comparator
    SDIP
    Outcome group
    Receptor activity and mechanism · Immune and inflammation

    Source sentences

    Summary
    Its physicochemical properties (electrophoretic mobility, u.v. spectra, absence of dansyl derivative) and its enzymatic susceptibilities (proteolytic enzymes, RNase, and DNase) were similar to those of the thymic hormone 'FTS'.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  3. 06LabNot a test of Thymulin (serum thymic factor) aloneIn vitro (cell-free)Activity measurement

    In chromatography, FTS and SDIP had identical retention times in three systems.

    In plain wordsIn lab tests, FTS and SDIP had identical retention times.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    Not applicableChromatographic retention
    Study

    n: not reported in source

    Comparator
    SDIP
    Outcome group
    Receptor activity and mechanism · Immune and inflammation

    Source sentences

    Summary
    SDIP and FTS were eluted with identical retention times in high performance liquid chromatography analysis in three different systems.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  4. 07LabNot a test of Thymulin (serum thymic factor) aloneIn vitro (cell-free)Activity measurement

    In the FTS radioimmunoassay, SDIP activity was similar to FTS activity.

    In plain wordsIn lab tests, SDIP and FTS had similar radioimmunoassay activity.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    Not applicableRadioimmunoassay activity
    Study

    n: not reported in source

    Comparator
    SDIP
    Outcome group
    Receptor activity and mechanism · Immune and inflammation

    Source sentences

    Summary
    When tested in sheep cell rosettes, and in the FTS radioimmunoassay in J.F. Bach's laboratory, SDIP presented an activity similar to FTS.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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