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Study · Ex vivo tissue · rat · 1983

10 results

Neurohypophysial peptides and the hippocampus. II. Excitation of rat hippocampal neurones by oxytocin and vasopressin applied in vitro.

Tiberiis BE, McLennan H, Wilson N

Neuropeptides1 Dec 1983Cited by 33 (Europe PMC)

PMID6669225 (opens in a new tab)DOI10.1016/0143-4179(83)90011-2 (opens in a new tab)PepBankPUB-06669225
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueActivity measurement

    In rat hippocampal slices, prolyl-leucyl-glycinamide had no effect on neuronal activity.

    In plain wordsIn lab tests, prolyl-leucyl-glycinamide did not change nerve cell activity in rat hippocampal slices.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    No significant changeHippocampal neuronal activity
    Study

    ratn: not reported in source

    hippocampal slices
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · superfusionAs given in this study (rat).

    Source sentences

    Summary
    but the oxytocin fragment prolyl-leucyl-glycinamide had no effect
    1 context sentence
    Summary · context
    Neurohypophysial peptides were applied by superfusion to rat hippocampal slices.

Studies that did not test the peptide alone9

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 02LabNot a test of Oxytocin aloneEx vivo tissueActivity measurement

    In rat hippocampal slices, the four neurohypophysial peptides, including oxytocin, increased activity in 88% of spontaneously active CA1 cells.

    In plain wordsIn lab tests of rat brain slices, the four-peptide group including oxytocin increased activity in 88% of active CA1 cells.

    Peptide
    Oxytocin
    Outcome
    IncreaseActivity of spontaneously active CA1 cells
    Study

    ratn: not reported in source

    hippocampal slices
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Measurements

    Responsive cells
    88%
    spontaneously active CA1 cells

    Source sentences

    Summary
    The peptides, arginine vasopressin, lysine vasopressin, arginine vasotocin and oxytocin, increased the activity of 88% of spontaneously active cells in the CA1 region and induced firing in many neurones that were not spontaneously active.
    1 context sentence
    Summary · context
    Neurohypophysial peptides were applied by superfusion to rat hippocampal slices.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 03LabNot a test of Oxytocin aloneEx vivo tissueActivity measurement

    In rat hippocampal slices, the four neurohypophysial peptides, including oxytocin, induced firing in many neurons that were not spontaneously active.

    In plain wordsIn lab tests of rat brain slices, the four-peptide group including oxytocin triggered firing in many previously inactive neurons.

    Peptide
    Oxytocin
    Outcome
    IncreaseFiring in previously inactive hippocampal neurons
    Study

    ratn: not reported in source

    hippocampal slices
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    The peptides, arginine vasopressin, lysine vasopressin, arginine vasotocin and oxytocin, increased the activity of 88% of spontaneously active cells in the CA1 region and induced firing in many neurones that were not spontaneously active.
    1 context sentence
    Summary · context
    Neurohypophysial peptides were applied by superfusion to rat hippocampal slices.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  3. 04LabNot a test of Oxytocin aloneEx vivo tissueActivity measurement

    In rat hippocampal slices, the four neurohypophysial peptides, including oxytocin, produced reversible dose-dependent responses from 10(-9) to 10(-6) M.

    In plain wordsIn lab tests of rat brain slices, the four-peptide group including oxytocin produced reversible responses that rose with dose.

    Peptide
    Oxytocin
    Outcome
    IncreaseDose-dependent hippocampal neuronal response
    Study

    ratn: not reported in source

    hippocampal slices
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    The four peptides were found to be of roughly equivalent potency, producing a reversible, dose-dependent response in the range 10(-9) to 10(-6)M.
    2 context sentences
    Summary · context
    The peptides, arginine vasopressin, lysine vasopressin, arginine vasotocin and oxytocin, increased the activity of 88% of spontaneously active cells in the CA1 region and induced firing in many neurones that were not spontaneously active.
    Summary · context
    Neurohypophysial peptides were applied by superfusion to rat hippocampal slices.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  4. 05LabNot a test of Oxytocin aloneEx vivo tissueMechanism

    In rat hippocampal slices, responses to the four neurohypophysial peptides, including oxytocin, could be blocked by specific antagonists.

    In plain wordsIn lab tests of rat brain slices, antagonists could block responses to the four-peptide group including oxytocin.

    Peptide
    Oxytocin
    Outcome
    DecreaseAntagonist blockade of oxytocin-related neuronal responses
    Study

    ratn: not reported in source

    hippocampal slices
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    Responses to the peptides could be blocked by "specific" antagonists.
    2 context sentences
    Summary · context
    The peptides, arginine vasopressin, lysine vasopressin, arginine vasotocin and oxytocin, increased the activity of 88% of spontaneously active cells in the CA1 region and induced firing in many neurones that were not spontaneously active.
    Summary · context
    Neurohypophysial peptides were applied by superfusion to rat hippocampal slices.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  5. 06LabNot a test of Oxytocin aloneEx vivo tissueMechanism

    In rat hippocampal slices, results suggested that the four neurohypophysial peptides, including oxytocin, acted through a single receptor class.

    In plain wordsIn lab tests of rat brain slices, results suggested one receptor class for the four-peptide group including oxytocin.

    Peptide
    Oxytocin
    Outcome
    Not applicableReceptor class mediating oxytocin-related neuronal responses
    Study

    ratn: not reported in source

    hippocampal slices
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    The results suggest that all of the peptides are acting upon a single class of receptor.
    2 context sentences
    Summary · context
    The peptides, arginine vasopressin, lysine vasopressin, arginine vasotocin and oxytocin, increased the activity of 88% of spontaneously active cells in the CA1 region and induced firing in many neurones that were not spontaneously active.
    Summary · context
    Neurohypophysial peptides were applied by superfusion to rat hippocampal slices.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  6. 07LabNot a test of Oxytocin aloneEx vivo tissueMechanism

    In rat hippocampal slices, cells sensitive to the four neurohypophysial peptides, including oxytocin, appeared to be pyramidal cells rather than interneurons.

    In plain wordsIn lab tests of rat brain slices, cells sensitive to the four-peptide group including oxytocin appeared to be pyramidal cells, not interneurons.

    Peptide
    Oxytocin
    Outcome
    Not applicablePeptide-sensitive hippocampal cell phenotype
    Study

    ratn: not reported in source

    hippocampal slices
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    The peptide sensitive cells appeared to be pyramidal cells rather than interneurones.
    2 context sentences
    Summary · context
    The peptides, arginine vasopressin, lysine vasopressin, arginine vasotocin and oxytocin, increased the activity of 88% of spontaneously active cells in the CA1 region and induced firing in many neurones that were not spontaneously active.
    Summary · context
    Neurohypophysial peptides were applied by superfusion to rat hippocampal slices.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  7. 08LabNot a test of Oxytocin aloneEx vivo tissueMechanism

    In rat hippocampal slices, most cells tested with more than one of the four neurohypophysial peptides, including oxytocin, responded either to all peptides tested or to none.

    In plain wordsIn lab tests of rat brain slices, cells tested with more than one peptide including oxytocin responded to all tested peptides or none.

    Peptide
    Oxytocin
    Outcome
    Not applicableMulti-peptide response pattern
    Study

    ratn: not reported in source

    hippocampal slices
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    Most of the cells were tested with more than one peptide and were always found to respond either to all or to none of them.
    2 context sentences
    Summary · context
    The peptides, arginine vasopressin, lysine vasopressin, arginine vasotocin and oxytocin, increased the activity of 88% of spontaneously active cells in the CA1 region and induced firing in many neurones that were not spontaneously active.
    Summary · context
    Neurohypophysial peptides were applied by superfusion to rat hippocampal slices.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  8. 09LabNot a test of Oxytocin aloneEx vivo tissueActivity measurement

    In rat hippocampal slices, the four neurohypophysial peptides, including oxytocin, were of roughly equivalent potency.

    In plain wordsIn lab tests of rat brain slices, the four-peptide group including oxytocin had roughly similar potency.

    Peptide
    Oxytocin
    Outcome
    Not applicableRelative potency of neurohypophysial peptides
    Study

    ratn: not reported in source

    hippocampal slices
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    The four peptides were found to be of roughly equivalent potency, producing a reversible, dose-dependent response in the range 10(-9) to 10(-6)M.
    2 context sentences
    Summary · context
    The peptides, arginine vasopressin, lysine vasopressin, arginine vasotocin and oxytocin, increased the activity of 88% of spontaneously active cells in the CA1 region and induced firing in many neurones that were not spontaneously active.
    Summary · context
    Neurohypophysial peptides were applied by superfusion to rat hippocampal slices.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  9. 10LabNot a test of Oxytocin aloneEx vivo tissueActivity measurement

    In rat hippocampal slices, [7-glycine]oxytocin and deamino,dicarba derivatives of oxytocin and vasopressin were about as active as their parent compounds.

    In plain wordsIn lab tests of rat brain slices, modified oxytocin and vasopressin peptides were about as active as their parent peptides.

    Peptide
    Oxytocin
    Outcome
    Not applicableActivity of oxytocin and vasopressin analogues relative to parent compounds
    Study

    ratn: not reported in source

    hippocampal slices
    Comparator
    Parent compounds (oxytocin and vasopressin)
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    The analogue [7-glycine]oxytocin and the deamino, dicarba derivatives of oxytocin and vasopressin were about as active as the parent compounds, but the oxytocin fragment prolyl-leucyl-glycinamide had no effect, and desglycinamide vasopressin was extremely weak.
    1 context sentence
    Summary · context
    Neurohypophysial peptides were applied by superfusion to rat hippocampal slices.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 4 to 9Current

    28 Oct 2026, 02:03 UTC

    The same notice was added 6 times, first on 22 Oct 2026, 02:26 UTC. The status did not change between them.

    Study results updated

  2. Version 3

    21 Oct 2026, 18:59 UTC

    Study data updated · source update from Europe PMC

  3. Version 2

    11 Oct 2026, 20:03 UTC

    Study results updated

  4. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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