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Study · Animal study (in vivo) · rat · 1983

5 results

Estrogen agonistic and antagonistic action of 8 non-steroidal antiestrogens on progestin receptor induction in rat pituitary gland and uterus.

Kirchhoff J, Grünke W, Hoffmann B, Nagel W, Ghraf R

Brain research1 Dec 1983Cited by 5 (Europe PMC)

PMID6661654 (opens in a new tab)DOI10.1016/0006-8993(83)90047-1 (opens in a new tab)PepBankPUB-06661654
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In ovariectomized rats, antiestrogens including enclomiphene considerably increased uterine progestin receptor concentration.

    In plain wordsIn rats without ovaries, enclomiphene increased uterine progestin receptor levels.

    Peptide
    Enclomiphene
    Outcome
    IncreaseUterine progestin receptor concentration
    Study

    ratn: not reported in source

    Ovariectomized rats
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    All 8 non-steroidal antiestrogens tested considerably increased progestin receptor concentration in the uterus and, to a lesser extent, in the pituitary of ovariectomized rats.
    1 context sentence
    Summary · context
    However, the pituitary was more sensitive than the uterus to the estrogen antagonistic action of these compounds, in that monohydroxytamoxifen, LY 117,018, enclomiphene, nitromifen, nafoxidine and trans-tamoxifen completely blocked progestin receptor induction by estradiol benzoate.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In ovariectomized rats, antiestrogens including enclomiphene increased pituitary progestin receptor concentration less than uterine concentration.

    In plain wordsIn rats without ovaries, enclomiphene increased pituitary progestin receptor levels less than uterine levels.

    Peptide
    Enclomiphene
    Outcome
    IncreasePituitary progestin receptor concentration
    Study

    ratn: not reported in source

    Ovariectomized rats
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    All 8 non-steroidal antiestrogens tested considerably increased progestin receptor concentration in the uterus and, to a lesser extent, in the pituitary of ovariectomized rats.
    1 context sentence
    Summary · context
    However, the pituitary was more sensitive than the uterus to the estrogen antagonistic action of these compounds, in that monohydroxytamoxifen, LY 117,018, enclomiphene, nitromifen, nafoxidine and trans-tamoxifen completely blocked progestin receptor induction by estradiol benzoate.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In ovariectomized rats, enclomiphene completely blocked estradiol-induced pituitary progestin receptor induction.

    In plain wordsIn rats without ovaries, enclomiphene blocked estradiol-induced progestin receptor production in the pituitary.

    Peptide
    Enclomiphene
    Outcome
    DecreaseEstradiol-induced pituitary progestin receptor induction
    Study

    ratn: not reported in source

    Ovariectomized rats
    Comparator
    Estradiol benzoate
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, the pituitary was more sensitive than the uterus to the estrogen antagonistic action of these compounds, in that monohydroxytamoxifen, LY 117,018, enclomiphene, nitromifen, nafoxidine and trans-tamoxifen completely blocked progestin receptor induction by estradiol benzoate.

Studies that did not test the peptide alone2

In this study, Enclomiphene was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Enclomiphene.

  1. 04AnimalNot a test of Enclomiphene aloneAnimal study (in vivo)Mechanism

    Across antiestrogens including enclomiphene, estrogen receptor binding affinity did not correlate with in vivo estrogen agonistic potency in rat tissues.

    In plain wordsIn rats, pooled antiestrogen results showed no correlation between receptor affinity and estrogen-like potency.

    Peptide
    Enclomiphene
    Outcome
    No significant changeBinding affinity versus estrogenic potency
    Study

    ratn: not reported in source

    Ovariectomized rats
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    In these tissues the order of the in vitro binding affinity of antiestrogens to cytoplasmic estrogen receptors was not correlated with either their in vivo estrogen agonistic or antagonistic potency.
    1 context sentence
    Summary · context
    However, the pituitary was more sensitive than the uterus to the estrogen antagonistic action of these compounds, in that monohydroxytamoxifen, LY 117,018, enclomiphene, nitromifen, nafoxidine and trans-tamoxifen completely blocked progestin receptor induction by estradiol benzoate.

    In this study, Enclomiphene was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Enclomiphene.

  2. 05AnimalNot a test of Enclomiphene aloneAnimal study (in vivo)Mechanism

    Across antiestrogens including enclomiphene, estrogen receptor binding affinity did not correlate with in vivo estrogen antagonistic potency in rat tissues.

    In plain wordsIn rats, pooled antiestrogen results showed no correlation between receptor affinity and estrogen-blocking potency.

    Peptide
    Enclomiphene
    Outcome
    No significant changeBinding affinity versus antiestrogenic potency
    Study

    ratn: not reported in source

    Ovariectomized rats
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    In these tissues the order of the in vitro binding affinity of antiestrogens to cytoplasmic estrogen receptors was not correlated with either their in vivo estrogen agonistic or antagonistic potency.
    1 context sentence
    Summary · context
    However, the pituitary was more sensitive than the uterus to the estrogen antagonistic action of these compounds, in that monohydroxytamoxifen, LY 117,018, enclomiphene, nitromifen, nafoxidine and trans-tamoxifen completely blocked progestin receptor induction by estradiol benzoate.

    In this study, Enclomiphene was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Enclomiphene.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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