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Study · Not a test of the peptide alone · 1983

2 results

Potent antagonists of the antidiuretic responses to arginine-vasopressin based on modifications of [1-(beta-mercapto-beta,beta-cyclopentamethylenepropionic acid),2-D- phenylalanine,4-valine]arginine-vasopressin at position 4.

Manning M, Olma A, Klis WA, Seto J, Sawyer WH

Journal of medicinal chemistry1 Nov 1983Cited by 19 (Europe PMC)

PMID6631916 (opens in a new tab)DOI10.1021/jm00365a011 (opens in a new tab)PepBankPUB-06631916
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 01AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Activity measurement

    In rats, analogues 1, 2, 3, and 5 antagonized in vivo oxytocic responses to oxytocin.

    In plain wordsIn rats, analogues 1, 2, 3, and 5 blocked oxytocin-related responses.

    Peptide
    Oxytocin
    Outcome
    DecreaseOxytocin-induced oxytocic response
    Study

    ratn: not reported in source

    in vivo oxytocic assay
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Analogues 1, 2, 3, and 5 have also been shown to antagonize the in vivo oxytocic responses to oxytocin.
    1 context sentence
    Summary · context
    Analogues 1-14 were tested for agonistic and antagonistic activities by antidiuretic, vasopressor, and oxytocic assays in rats.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 02LabNot a test of Oxytocin aloneEx vivo tissueActivity measurement

    In rat in vitro oxytocic assays, arginine-vasopressin analogues 1-14 antagonized responses to oxytocin.

    In plain wordsIn lab tests of rat tissue, analogues 1-14 blocked responses to oxytocin.

    Peptide
    Oxytocin
    Outcome
    DecreaseOxytocin-induced oxytocic response
    Study

    ratn: not reported in source

    in vitro oxytocic assay
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Analogues 1-14 also antagonize the vascular responses to arginine-vasopressin (AVP) and the in vitro oxytocic responses to oxytocin.
    1 context sentence
    Summary · context
    Analogues 1-14 were tested for agonistic and antagonistic activities by antidiuretic, vasopressor, and oxytocic assays in rats.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:54 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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