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Study · In vitro (cells) · 1984

3 results

Thymosin increases production of T-cell growth factor by normal human peripheral blood lymphocytes.

Zatz MM, Oliver J, Samuels C, Skotnicki AB, Sztein MB, Goldstein AL

Proceedings of the National Academy of Sciences of the United States of America1 May 1984Cited by 25 (Europe PMC)

PMID6609371 (opens in a new tab)PMCIDPMC345176 (opens in a new tab)DOI10.1073/pnas.81.9.2882 (opens in a new tab)PepBankPUB-06609371
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In human lymphocytes, the biological activity of thymosin fraction 5 was not attributed to thymosin alpha‑1.

    In plain wordsIn lab cultures, the effect of the thymosin mixture was not explained by thymosin alpha‑1.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeContribution of thymosin alpha 1 to the T-cell growth factor effect of fraction 5
    Study

    humann: not reported in source

    PHA-stimulated peripheral blood lymphocytes
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The biological activity of thymosin fraction 5 cannot be attributed to the activity of thymosin alpha 1, one of the well-characterized peptide components of fraction 5.

Studies that did not test the peptide alone2

In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin alpha-1.

  1. 02LabNot a test of Thymosin alpha-1 aloneIn vitro (cells)Activity measurement

    In human lymphocytes stimulated with phytohemagglutinin, a thymosin preparation (fraction 5) increased production of T-cell growth factor in a dose-dependent way.

    In plain wordsIn lab cultures of human white blood cells, a thymosin mixture raised production of a T-cell growth factor.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseT-cell growth factor production
    Study

    humann: not reported in source

    PHA-stimulated peripheral blood lymphocytes
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    The in vitro incubation of phytohemagglutinin-stimulated peripheral blood lymphocytes with thymosin results in a marked and reproducible increase in production of T-cell growth factor, which is dose dependent and most pronounced in the first 24 hr of culture.
    1 context sentence
    Summary · context
    The biological activity of thymosin fraction 5 cannot be attributed to the activity of thymosin alpha 1, one of the well-characterized peptide components of fraction 5.

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

  2. 03LabNot a test of Thymosin alpha-1 aloneIn vitro (cells)Activity measurement

    In human lymphocytes, thymosin alone did not induce any production of T-cell growth factor.

    In plain wordsIn lab cultures of human white blood cells, a thymosin mixture alone did not trigger a T-cell growth factor.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeT-cell growth factor production without phytohemagglutinin
    Study

    humann: not reported in source

    peripheral blood lymphocytes
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    Incubation of lymphocytes with thymosin alone failed to induce any production of T-cell growth factor.

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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