Prothymosin alpha: isolation and properties of the major immunoreactive form of thymosin alpha 1 in rat thymus.

Haritos AA, Goodall GJ, Horecker BL

Proceedings of the National Academy of Sciences of the United States of America1 Feb 1984Cited by 145 (Europe PMC)

PMID6583693PMCIDPMC344752DOI10.1073/pnas.81.4.1008PepBankPUB-06583693

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01AnimalEndogenous levelAnimal study (in vivo)Other
In rat thymus extracts, no peptides corresponding to thymosin alpha‑1 were detected; the major cross-reacting substance was prothymosin alpha.
In plain wordsIn rats, the thymus held no free form of the body's own thymosin alpha‑1; the cross-reacting substance was the larger prothymosin alpha.
Peptide
Thymosin alpha-1
Outcome
No significant changeThymosin alpha 1-sized peptide in rat thymus extracts
Study
ratn: not reported in source
rat thymus extract
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
peptides corresponding to thymosin alpha 1 or thymosin alpha 11 were not detected
This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0658369301

Studies that did not test the peptide alone1

In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin alpha-1.

02LabNot a test of Thymosin alpha-1 aloneIn vitro (cell-free)Other
On gel filtration columns, synthetic thymosin alpha‑1 (calculated Mr 3108) eluted at an apparent molecular weight of 10,000-11,000, which suggests oligomers in solution.
In plain wordsIn lab tests, synthetic thymosin alpha‑1 behaved as a larger molecule than its calculated size, which suggests it forms small clusters in solution.
Peptide
Thymosin alpha-1
Outcome
Not applicableApparent molecular weight of synthetic thymosin alpha 1 on gel filtration
Study
n: not reported in source
gel filtration columns, synthetic peptide
Outcome group
Peptide structure and chemistry · Pharmacology
Measurements
Apparent molecular weight
10 to 11 Mr
synthetic thymosin alpha 1, gel filtration
Source sentences
Summary
On the same gel filtration columns, synthetic thymosin alpha 1 (calculated Mr = 3108) emerged at a position corresponding to a molecular weight of 10,000-11,000.
1 context sentence(design, population, supporting numbers)
Summary · context
Thus, both prothymosin alpha and thymosin alpha 1 appear to exist in solution as oligomers, possibly as trimers.
In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.
Report a problemFND-0658369302

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
10 Oct 2026, 08:55 UTC
Study results updated
Version 2
9 Oct 2026, 03:03 UTC
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 03:02 UTC
First added · source update from Europe PMC