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Study · Animal study (in vivo) · mouse · 1983

7 results

Modulation of endogenous prostaglandins by thymosin-alpha 1 in lymphocytes.

Rinaldi-Garaci C, Garaci E, Del Gobbo V, Favalli C, Jezzi T, Goldstein AL

Cellular immunology1 Aug 1983Cited by 15 (Europe PMC)

PMID6575878 (opens in a new tab)DOI10.1016/0008-8749(83)90093-x (opens in a new tab)PepBankPUB-06575878
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Pharmacokinetics

    After administration of synthetic thymosin alpha‑1 in mice, alpha 1 activity in blood peaked after 1 hr.

    In plain wordsIn mice, the activity of thymosin alpha‑1 in blood reached its highest point 1 hour after a dose.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableTime to peak thymosin alpha 1 activity in blood
    Study

    mousen: not reported in source

    Adult thymectomized (ATx) mice
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Measurements

    Time to maximum alpha 1 activity
    1 hr
    blood

    Source sentences

    Summary
    A maximum peak of alpha 1 activity was obtained after 1 hr, while maximal FTS-like activity was observed after 24 hr.
    2 context sentences
    Summary · context
    Experiments were also performed to study in parallel the absolute levels of thymosin-alpha 1 in the blood and the induction of serum FTS activity and of azathioprine sensitivity of spleen cells from adult thymectomized (ATx) mice.
    Summary · context
    The effects of thymosin-alpha 1 on the stimulation of specific release of prostaglandin E2 (PGE2) from splenic lymphocytes and thymocytes were studied.
  2. 02AnimalAnimal study (in vivo)Activity measurement

    After thymosin alpha‑1 administration in mice, FTS-like activity in blood reached its maximum after 24 hr, later than the alpha 1 peak.

    In plain wordsIn mice, thymosin alpha‑1 raised a thymic-hormone-like activity in blood, which was highest after 24 hours.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseTime to maximal FTS-like activity in blood
    Study

    mousen: not reported in source

    Adult thymectomized (ATx) mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Measurements

    Time to maximal FTS-like activity
    24 hr
    blood

    Source sentences

    Summary
    A maximum peak of alpha 1 activity was obtained after 1 hr, while maximal FTS-like activity was observed after 24 hr.
    2 context sentences
    Summary · context
    Experiments were also performed to study in parallel the absolute levels of thymosin-alpha 1 in the blood and the induction of serum FTS activity and of azathioprine sensitivity of spleen cells from adult thymectomized (ATx) mice.
    Summary · context
    The effects of thymosin-alpha 1 on the stimulation of specific release of prostaglandin E2 (PGE2) from splenic lymphocytes and thymocytes were studied.
  3. 03AnimalAnimal study (in vivo)Mechanism

    Indomethacin inhibited the induction of FTS-like activity and Thy 1.2 antigen by thymosin alpha‑1, which suggests that the action of alpha 1 requires prostaglandin biosynthesis.

    In plain wordsIn mice, a drug that blocks prostaglandin production stopped thymosin alpha‑1 effects, which suggests alpha 1 needs prostaglandins to act.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableProstaglandin dependence of alpha 1 action (indomethacin block)
    Study

    mousen: not reported in source

    Mice
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The inhibition of the induction by alpha 1 of FTS-like activity and of Thy 1.2 antigen by indomethacin suggests that the action of alpha 1 requires prostaglandin biosynthesis.
    1 context sentence
    Summary · context
    The effects of thymosin-alpha 1 on the stimulation of specific release of prostaglandin E2 (PGE2) from splenic lymphocytes and thymocytes were studied.
  4. 04LabEx vivo tissueActivity measurement

    In splenic lymphocytes from adult thymectomized mice, thymosin alpha‑1 at certain concentrations stimulated release of prostaglandin E2.

    In plain wordsIn lab tests on mouse immune cells, thymosin alpha‑1 raised prostaglandin E2 release from cells of thymectomized mice.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreasePGE2 release from lymphocytes of ATx mice
    Study

    mousen: not reported in source

    Splenic lymphocytes from adult thymectomized (ATx) mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Thymosin-alpha 1 at certain concentrations was able to stimulate PGE2 release from lymphocytes of ATx mice while inhibiting release in lymphocytes of normal mice.
    1 context sentence
    Summary · context
    The effects of thymosin-alpha 1 on the stimulation of specific release of prostaglandin E2 (PGE2) from splenic lymphocytes and thymocytes were studied.
  5. 05LabEx vivo tissueActivity measurement

    In lymphocytes from normal mice, thymosin alpha‑1 at certain concentrations inhibited release of prostaglandin E2.

    In plain wordsIn lab tests on mouse immune cells, thymosin alpha‑1 lowered prostaglandin E2 release from cells of normal mice.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreasePGE2 release from lymphocytes of normal mice
    Study

    mousen: not reported in source

    Splenic lymphocytes from normal mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Thymosin-alpha 1 at certain concentrations was able to stimulate PGE2 release from lymphocytes of ATx mice while inhibiting release in lymphocytes of normal mice.
    1 context sentence
    Summary · context
    The effects of thymosin-alpha 1 on the stimulation of specific release of prostaglandin E2 (PGE2) from splenic lymphocytes and thymocytes were studied.
  6. 06LabEx vivo tissueActivity measurement

    Thymosin alpha‑1 stimulated thymocytes to release prostaglandin E2, in a manner similar to spleen cells of ATx mice.

    In plain wordsIn lab tests on mouse thymus cells, thymosin alpha‑1 raised prostaglandin E2 release.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreasePGE2 release from thymocytes
    Study

    mousen: not reported in source

    Thymocytes
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Also, thymocytes were stimulated to release PGE2 after incubation with alpha 1 in a manner similar to that seen in spleen cells of ATx mice.
    1 context sentence
    Summary · context
    The effects of thymosin-alpha 1 on the stimulation of specific release of prostaglandin E2 (PGE2) from splenic lymphocytes and thymocytes were studied.
  7. 07LabEx vivo tissueActivity measurement

    At about the same concentrations, thymosin alpha‑1 corrected the low azathioprine sensitivity of splenocytes from ATx mice.

    In plain wordsIn lab tests on mouse spleen cells, thymosin alpha‑1 corrected the low sensitivity to azathioprine.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseAzathioprine sensitivity of splenocytes from ATx mice
    Study

    mousen: not reported in source

    Splenocytes from ATx mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Approximately the same concentrations of alpha 1 was found to also correct the low azathioprine sensitivity of splenocytes from ATx mice.
    1 context sentence
    Summary · context
    The effects of thymosin-alpha 1 on the stimulation of specific release of prostaglandin E2 (PGE2) from splenic lymphocytes and thymocytes were studied.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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