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Study · Animal study (in vivo) · mouse · 1983

5 results

Thymosin alpha 1 restores NK-cell activity and prevents tumor progression in mice immunosuppressed by cytostatics or X-rays.

Umeda Y, Sakamoto A, Nakamura J, Ishitsuka H, Yagi Y

Cancer immunology, immunotherapy : CII1 Jan 1983Cited by 30 (Europe PMC)

PMID6553515 (opens in a new tab)PMCIDPMC11039271 (opens in a new tab)DOI10.1007/bf00199694 (opens in a new tab)PepBankPUB-06553515
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In immunosuppressed mice with P388 or L1210 leukemia, thymosin alpha‑1 prevented rapid death and extended survival.

    In plain wordsIn mice with weakened immunity and leukemia, thymosin alpha‑1 delayed early death and extended survival.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseSurvival of immunosuppressed mice with leukemia
    Study

    mousen: not reported in source

    Mice immunosuppressed by 5-FU, BCNU or X-ray, inoculated with P388 or L1210 leukemia
    Comparator
    Cytostatic agent or X-ray without thymosin alpha 1
    Outcome group
    Mortality · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In these systems, thymosin alpha 1 given concomitantly with the cytostatic agents or after X-irradiation prevented rapid death and extended survival, although the mice eventually died with leukemia like normal mice inoculated with cells of the same tumor.
    1 context sentence
    Summary · context
    When pretreated with cytostatic agents, such as 5-fluorouracil (5-FU) or BCNU, or by X-ray, and then inoculated with P388 or L1210 leukemias, mice died rapidly within a few days.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In immunosuppressed mice, thymosin alpha‑1 did not prevent eventual death from leukemia, as in normal mice given the same tumor cells.

    In plain wordsIn mice, thymosin alpha‑1 did not stop the mice from eventually dying of leukemia.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeEventual death from leukemia
    Study

    mousen: not reported in source

    Mice immunosuppressed by 5-FU, BCNU or X-ray, inoculated with P388 or L1210 leukemia
    Outcome group
    Mortality · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In these systems, thymosin alpha 1 given concomitantly with the cytostatic agents or after X-irradiation prevented rapid death and extended survival, although the mice eventually died with leukemia like normal mice inoculated with cells of the same tumor.
    1 context sentence
    Summary · context
    When pretreated with cytostatic agents, such as 5-fluorouracil (5-FU) or BCNU, or by X-ray, and then inoculated with P388 or L1210 leukemias, mice died rapidly within a few days.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In 5-FU-treated mice, spleen cells from donors treated with 5-FU plus thymosin alpha‑1 prevented rapid death, but cells from donors given 5-FU alone did not.

    In plain wordsIn mice, spleen cells from donors given thymosin alpha‑1 with 5-FU protected against early death; cells from donors given 5-FU alone did not.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreasePrevention of rapid death by adoptive transfer of spleen cells
    Study

    mousen: not reported in source

    Mice immunosuppressed by 5-FU, BCNU or X-ray, inoculated with P388 or L1210 leukemia
    Comparator
    Spleen cells from donors given 5-FU alone
    Outcome group
    Mortality · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Rapid death in the 5-FU-treated mice was also prevented by adoptive transfer of spleen cells from the donor mice if these had been treated with 5-FU plus thymosin alpha 1, but not if they had received 5-FU alone.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In mice, the restorative activity of donor spleen cells from thymosin alpha‑1 treated donors was abrogated by anti-asialo GM1 but not by anti-Thy 1 or anti-mouse Ig serum, suggesting NK cells.

    In plain wordsIn mice, the protective effect of spleen cells from thymosin-treated donors was lost after anti-asialo GM1 treatment, suggesting NK cells.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableEffector cell type of the donor spleen cell effect
    Study

    mousen: not reported in source

    Mice immunosuppressed by 5-FU, BCNU or X-ray, inoculated with P388 or L1210 leukemia
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, the restorative activity of the donor spleen cells was abrogated by treatment with anti-asialo GM1, but not by treatment with anti-Thy 1 or anti-mouse Ig serum, suggesting that the effector cells in the spleen are NK cells.
    1 context sentence
    Summary · context
    Rapid death in the 5-FU-treated mice was also prevented by adoptive transfer of spleen cells from the donor mice if these had been treated with 5-FU plus thymosin alpha 1, but not if they had received 5-FU alone.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In mice, thymosin alpha‑1 given with 5-FU or after X-irradiation maintained spleen NK activity that treatment with 5-FU or X-irradiation alone damaged.

    In plain wordsIn mice, thymosin alpha‑1 kept spleen NK cell activity up compared with 5-FU or X-rays alone.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseSpleen NK cell activity
    Study

    mousen: not reported in source

    Mice immunosuppressed by 5-FU, BCNU or X-ray, inoculated with P388 or L1210 leukemia
    Comparator
    5-FU or X-irradiation alone
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In fact, thymosin alpha 1, when given concomitantly with 5-FU or after X-irradiation, maintained the NK activity of spleen, which was damaged by treatment with 5-FU or X-irradiation alone.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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