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Study · Animal study (in vivo) · mouse · 1983

7 results

Immunomodulating activity of thymosin fraction 5 and thymosin alpha 1 in immunosuppressed mice.

Ohta Y, Sueki K, Yoneyama Y, Tezuka E, Yagi Y

Cancer immunology, immunotherapy : CII1 Jan 1983Cited by 12 (Europe PMC)

PMID6553511 (opens in a new tab)PMCIDPMC11039167 (opens in a new tab)DOI10.1007/bf00199700 (opens in a new tab)PepBankPUB-06553511
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice immunosuppressed with 5-FU, synthetic thymosin alpha‑1 restored cell-mediated immunity.

    In plain wordsIn mice with 5-FU-weakened immunity, thymosin alpha‑1 restored cell-mediated immune function.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseCell-mediated immunity after 5-FU suppression
    Study

    mousen: not reported in source

    Mice immunosuppressed by 5-FU
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We found that both thymosin from calf thymus and its constituent peptide alpha 1 prepared by chemical synthesis restore cell-mediated immunity following its suppression in mice by injection of 5-FU.
    1 context sentence
    Summary · context
    Conditions suitable for assessing the thymosin activity by means of footpad reaction were established in such immunosuppressed mice.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In the footpad-reaction model in 5-FU-immunosuppressed mice, thymosin alpha‑1 peptide was active at 5-50 micrograms/kg, 100-1,000 times less than thymosin fraction 5.

    In plain wordsIn mice with weakened immunity, thymosin alpha‑1 worked at doses 100 to 1,000 times lower than the crude thymosin fraction 5.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseFootpad reaction at low dose
    Study

    mousen: not reported in source

    Mice immunosuppressed by 5-FU
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    5-50 micrograms/kgAs given in this study (mouse).

    Measurements

    Active dose
    5 to 50 micrograms/kg
    footpad reaction

    Source sentences

    Summary
    In this new animal model, thymosin alpha 1-peptide showed activity at a low dose of 5-50 micrograms/kg, which was 100-1,000 times less than that required for thymosin F-5 preparations.
    1 context sentence
    Summary · context
    Conditions suitable for assessing the thymosin activity by means of footpad reaction were established in such immunosuppressed mice.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In adoptive transfer studies, alpha 1 peptide corrected the 5-FU-induced suppression of mature T cells that transfer the DTH response.

    In plain wordsIn mice, thymosin alpha‑1 corrected the loss of mature T-cell function caused by 5-FU.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseMature T-cell DTH response after 5-FU
    Study

    mousen: not reported in source

    Mice immunosuppressed by 5-FU
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Further studies utilizing the adoptive transfer technique showed that alpha 1-peptide corrects the 5-FU-induced suppression of mature T cells, transferring the DTH response as well as that of macrophage function responsible for the expression of footpad reaction.
    1 context sentence
    Summary · context
    Conditions suitable for assessing the thymosin activity by means of footpad reaction were established in such immunosuppressed mice.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In adoptive transfer studies, alpha 1 peptide corrected the 5-FU-induced suppression of macrophage function responsible for the footpad reaction.

    In plain wordsIn mice, thymosin alpha‑1 corrected the loss of macrophage function caused by 5-FU.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseMacrophage function after 5-FU
    Study

    mousen: not reported in source

    Mice immunosuppressed by 5-FU
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Further studies utilizing the adoptive transfer technique showed that alpha 1-peptide corrects the 5-FU-induced suppression of mature T cells, transferring the DTH response as well as that of macrophage function responsible for the expression of footpad reaction.
    1 context sentence
    Summary · context
    Conditions suitable for assessing the thymosin activity by means of footpad reaction were established in such immunosuppressed mice.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    Thymosin alpha‑1 enhanced regeneration of lymph node cells in 5-FU-treated mice.

    In plain wordsIn mice treated with 5-FU, thymosin alpha‑1 increased the regrowth of lymph node cells.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseRegeneration of lymph node cells
    Study

    mousen: not reported in source

    Mice immunosuppressed by 5-FU
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, regeneration of lymph node and bone marrow cells as well as CFU-c (progenitor cells of macrophages and granulocytes) was enhanced by thymosin alpha 1 in the 5-FU-treated mice.
    1 context sentence
    Summary · context
    Conditions suitable for assessing the thymosin activity by means of footpad reaction were established in such immunosuppressed mice.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    Thymosin alpha‑1 enhanced regeneration of bone marrow cells in 5-FU-treated mice.

    In plain wordsIn mice treated with 5-FU, thymosin alpha‑1 increased the regrowth of bone marrow cells.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseRegeneration of bone marrow cells
    Study

    mousen: not reported in source

    Mice immunosuppressed by 5-FU
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, regeneration of lymph node and bone marrow cells as well as CFU-c (progenitor cells of macrophages and granulocytes) was enhanced by thymosin alpha 1 in the 5-FU-treated mice.
    1 context sentence
    Summary · context
    Conditions suitable for assessing the thymosin activity by means of footpad reaction were established in such immunosuppressed mice.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    Thymosin alpha‑1 enhanced regeneration of CFU-c (macrophage and granulocyte progenitor cells) in 5-FU-treated mice.

    In plain wordsIn mice treated with 5-FU, thymosin alpha‑1 increased the regrowth of macrophage and granulocyte progenitor cells.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseRegeneration of CFU-c progenitor cells
    Study

    mousen: not reported in source

    Mice immunosuppressed by 5-FU
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, regeneration of lymph node and bone marrow cells as well as CFU-c (progenitor cells of macrophages and granulocytes) was enhanced by thymosin alpha 1 in the 5-FU-treated mice.
    1 context sentence
    Summary · context
    Conditions suitable for assessing the thymosin activity by means of footpad reaction were established in such immunosuppressed mice.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

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