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Study · Animal study (in vivo) · rat · 1984

4 results

Antagonism of the effect of delta sleep-inducing peptide by naloxone in the rat.

Young AM, Key BJ

Neuropharmacology1 Nov 1984Cited by 9 (Europe PMC)

PMID6549349 (opens in a new tab)DOI10.1016/0028-3908(84)90058-3 (opens in a new tab)PepBankPUB-06549349
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, DSIP injected into the lateral ventricle significantly increased REM sleep.

    In plain wordsIn rats, DSIP injected into the brain increased REM sleep.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseREM sleep
    Study

    ratn: not reported in source

    EEG-monitored rats, dark phase
    Outcome group
    Sleep · Sleep
    Studied dose
    4 doses of 5 micrograms · injection into the lateral ventricleAs given in this study (rat).

    Source sentences

    Summary
    The peptide caused a significant increase in both REM and non-REM sleep at the expense of waking when injected into the lateral ventricle of the rat brain in four doses of 5 micrograms during the dark (waking) phase of the light/dark cycle.
    1 context sentence
    Summary · context
    The somnogenic properties of delta sleep-inducing peptide (DSIP) were investigated using electroencephalographic criteria.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, DSIP injected into the lateral ventricle significantly increased non-REM sleep.

    In plain wordsIn rats, DSIP injected into the brain increased non-REM sleep.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseNon-REM sleep
    Study

    ratn: not reported in source

    EEG-monitored rats, dark phase
    Outcome group
    Sleep · Sleep
    Studied dose
    4 doses of 5 micrograms · injection into the lateral ventricleAs given in this study (rat).

    Source sentences

    Summary
    The peptide caused a significant increase in both REM and non-REM sleep at the expense of waking when injected into the lateral ventricle of the rat brain in four doses of 5 micrograms during the dark (waking) phase of the light/dark cycle.
    1 context sentence
    Summary · context
    The somnogenic properties of delta sleep-inducing peptide (DSIP) were investigated using electroencephalographic criteria.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats, DSIP injected into the lateral ventricle reduced waking time, as sleep increased at its expense.

    In plain wordsIn rats, DSIP injected into the brain reduced the time spent awake.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseWaking
    Study

    ratn: not reported in source

    EEG-monitored rats, dark phase
    Outcome group
    Sleep · Sleep
    Studied dose
    4 doses of 5 micrograms · injection into the lateral ventricleAs given in this study (rat).

    Source sentences

    Summary
    The peptide caused a significant increase in both REM and non-REM sleep at the expense of waking when injected into the lateral ventricle of the rat brain in four doses of 5 micrograms during the dark (waking) phase of the light/dark cycle.
    1 context sentence
    Summary · context
    The somnogenic properties of delta sleep-inducing peptide (DSIP) were investigated using electroencephalographic criteria.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats, pretreatment with naloxone at a mu-receptor-selective dose blocked the sleep-promoting effect of DSIP.

    In plain wordsIn rats, the opiate blocker naloxone stopped the sleep-promoting effect of DSIP.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeDSIP sleep effect after naloxone pretreatment
    Study

    ratn: not reported in source

    EEG-monitored rats, dark phase
    Comparator
    Naloxone pretreatment (0.1 mg/kg s.c.)
    Outcome group
    Sleep · Sleep
    Studied dose
    4 doses of 5 micrograms · injection into the lateral ventricleAs given in this study (rat).

    Source sentences

    Summary
    Furthermore this sleep promoting effect was blocked by pre-treatment with the opiate antagonist naloxone at a dose level (0.1 mg/Kg s.c.) considered selective for mu-receptors.
    1 context sentence
    Summary · context
    The somnogenic properties of delta sleep-inducing peptide (DSIP) were investigated using electroencephalographic criteria.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

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