Characterization of the relaxant effects of vasoactive intestinal peptide (VIP) and PHI on isolated brain arteries.

Suzuki Y, McMaster D, Lederis K, Rorstad OP

Brain research1 Nov 1984Cited by 59 (Europe PMC)

PMID6549149DOI10.1016/0006-8993(84)91175-2PepBankPUB-06549149

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueEfficacy outcome
VIP relaxed bovine middle, anterior and posterior cerebral arteries and the basilar artery with ED50 values of 1.8, 2.3, 6.8 and 9.0 nM.
In plain wordsIn lab tests on cow brain arteries, VIP relaxed the arteries at very low doses.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseRelaxation of bovine cerebral arteries (ED50)
Study
cattlen: not reported in source
helical strips of brain arteries
Outcome group
Vascular function · Cardiovascular
Studied dose
Dose not stated
Measurements
ED50
1.8 nM
middle cerebral artery
ED50
2.3 nM
anterior cerebral artery
ED50
6.8 nM
posterior cerebral artery
ED50
9 nM
basilar artery
Source sentences
Summary
Arteries supplying different regions of the bovine brain responded potently to VIP with ED50 values of 1.8 nM, 2.3 nM, 6.8 nM and 9.0 nM for the middle, anterior and posterior cerebral arteries and the basilar artery, respectively.
1 context sentence(design, population, supporting numbers)
Summary · context
We have studied the vasorelaxant properties of vasoactive intestinal peptide (VIP) using helical strips of bovine, porcine and human brain arteries in vitro.
Report a problemFND-0654914901
02LabEx vivo tissueEfficacy outcome
The porcine basilar artery responded to VIP with an ED50 of 4.2 nM.
In plain wordsIn lab tests on pig brain artery, VIP relaxed the artery at a very low dose.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseRelaxation of porcine basilar artery (ED50)
Study
pign: not reported in source
helical strips of brain arteries
Outcome group
Vascular function · Cardiovascular
Studied dose
Dose not stated
Measurements
ED50
4.2 nM
porcine basilar artery
Source sentences
Summary
The porcine basilar artery and branches of the human middle cerebral artery responded to VIP with ED50 values of 4.2 nM
1 context sentence(design, population, supporting numbers)
Summary · context
We have studied the vasorelaxant properties of vasoactive intestinal peptide (VIP) using helical strips of bovine, porcine and human brain arteries in vitro.
Report a problemFND-0654914902
03LabEx vivo tissueEfficacy outcome
Branches of the human middle cerebral artery responded to VIP with an ED50 of 1.6 nM.
In plain wordsIn lab tests on human brain artery tissue, VIP relaxed the artery at a very low dose.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseRelaxation of human middle cerebral artery branches (ED50)
Study
humann: not reported in source
helical strips of brain arteries
Outcome group
Vascular function · Cardiovascular
Studied dose
Dose not stated
Measurements
ED50
1.6 nM
human middle cerebral artery branches
Source sentences
Summary
The porcine basilar artery and branches of the human middle cerebral artery responded to VIP with ED50 values of 4.2 nM and 1.6 nM, respectively.
1 context sentence(design, population, supporting numbers)
Summary · context
We have studied the vasorelaxant properties of vasoactive intestinal peptide (VIP) using helical strips of bovine, porcine and human brain arteries in vitro.
Report a problemFND-0654914903
04LabEx vivo tissueEfficacy outcome
VIP relaxed the bovine middle cerebral and porcine basilar arteries more potently than the homologous neuropeptide PHI.
In plain wordsIn lab tests on cow and pig brain arteries, VIP relaxed the arteries more potently than PHI.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseRelaxation potency, VIP versus PHI
Study
cattle, pign: not reported in source
helical strips of brain arteries
Comparator
PHI
Outcome group
Vascular function · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
The homologous neuropeptide, PHI, relaxed the bovine middle cerebral and porcine basilar arteries less potently than did VIP, with ED50 values for PHI being 11 nM and 43 nM, respectively.
1 context sentence(design, population, supporting numbers)
Summary · context
We have studied the vasorelaxant properties of vasoactive intestinal peptide (VIP) using helical strips of bovine, porcine and human brain arteries in vitro.
Report a problemFND-0654914904
05LabEx vivo tissueEfficacy outcome
PHI elicited a maximal vasodilatory response of similar magnitude to VIP in the bovine middle cerebral and porcine basilar arteries.
In plain wordsIn lab tests on cow and pig brain arteries, PHI and VIP produced a similar maximal relaxation.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeMaximal relaxation, VIP versus PHI
Study
cattle, pign: not reported in source
helical strips of brain arteries
Comparator
PHI
Outcome group
Vascular function · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
However, PHI elicited in the two arteries a maximal vasodilatory response of similar magnitude as did VIP.
1 context sentence(design, population, supporting numbers)
Summary · context
We have studied the vasorelaxant properties of vasoactive intestinal peptide (VIP) using helical strips of bovine, porcine and human brain arteries in vitro.
Report a problemFND-0654914905
06LabEx vivo tissueEfficacy outcome
VIP oxidized to VIP-(Met17 sulfoxide) or VIP-(Met17 sulfone) retained full relaxant activity.
In plain wordsIn lab tests on brain arteries, oxidized forms of VIP kept their full relaxing activity.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeRelaxant activity of oxidized VIP
Study
n: not reported in source
helical strips of brain arteries
Comparator
Unoxidized VIP
Outcome group
Vascular function · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
In contrast, VIP, which had been oxidized to VIP-(Met17 sulfoxide) or VIP-(Met17 sulfone), retained full activity.
1 context sentence(design, population, supporting numbers)
Summary · context
We have studied the vasorelaxant properties of vasoactive intestinal peptide (VIP) using helical strips of bovine, porcine and human brain arteries in vitro.
Report a problemFND-0654914906

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

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