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Study · Animal study (in vivo) · rat · 1984

7 results

The effects of oxytocin and vasotocin analogues on the responses of rat brainstem neurones to oxytocin.

Morris R, Farmery SM, Roberts CJ, Hill RG

Neuroscience letters1 Jul 1984Cited by 9 (Europe PMC)

PMID6548301 (opens in a new tab)DOI10.1016/0304-3940(84)90013-2 (opens in a new tab)PepBankPUB-06548301
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Activity measurement

    In rat caudal brainstem neurones, microiontophoretic oxytocin reduced firing rates in 33.3% of recorded units.

    In plain wordsIn rat brainstem nerve cells, oxytocin reduced firing rates in 33.3% of recorded units.

    Peptide
    Oxytocin
    Outcome
    DecreaseNeuronal firing rate reduction
    Study

    ratn: not reported in source

    caudal brainstem neurones
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · microiontophoresisAs given in this study (rat).

    Measurements

    Units with reduced firing rates
    33.3%
    156 units recorded

    Source sentences

    Summary
    Of the sample of 156 units recorded the firing rates of 33.3% were reduced and those of 21.2% were raised by microiontophoretically applied oxytocin, whilst the remainder were unaffected.
    1 context sentence
    Summary · context
    The effects of microiontophoretically applied oxytocin on the firing rates of neurones in the rat caudal brainstem have been examined.
  2. 02AnimalAnimal study (in vivo)Activity measurement

    In rat caudal brainstem neurones, microiontophoretic oxytocin raised firing rates in 21.2% of recorded units.

    In plain wordsIn rat brainstem nerve cells, oxytocin raised firing rates in 21.2% of recorded units.

    Peptide
    Oxytocin
    Outcome
    IncreaseNeuronal firing rate increase
    Study

    ratn: not reported in source

    caudal brainstem neurones
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · microiontophoresisAs given in this study (rat).

    Measurements

    Units with raised firing rates
    21.2%
    156 units recorded

    Source sentences

    Summary
    Of the sample of 156 units recorded the firing rates of 33.3% were reduced and those of 21.2% were raised by microiontophoretically applied oxytocin, whilst the remainder were unaffected.
    1 context sentence
    Summary · context
    The effects of microiontophoretically applied oxytocin on the firing rates of neurones in the rat caudal brainstem have been examined.
  3. 03AnimalAnimal study (in vivo)Activity measurement

    In rat caudal brainstem neurones, the remainder of recorded units were unaffected by microiontophoretic oxytocin.

    In plain wordsIn rat brainstem nerve cells, the remaining recorded units were unaffected by oxytocin.

    Peptide
    Oxytocin
    Outcome
    No significant changeNeuronal firing rate unaffected
    Study

    ratn: not reported in source

    caudal brainstem neurones
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · microiontophoresisAs given in this study (rat).

    Source sentences

    Summary
    Of the sample of 156 units recorded the firing rates of 33.3% were reduced and those of 21.2% were raised by microiontophoretically applied oxytocin, whilst the remainder were unaffected.
    1 context sentence
    Summary · context
    The effects of microiontophoretically applied oxytocin on the firing rates of neurones in the rat caudal brainstem have been examined.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rat caudal brainstem neurones, the distribution of oxytocin-facilitated units tended to overlap with immunocytochemically demonstrated oxytocin.

    In plain wordsIn rat brainstem nerve cells, oxytocin-facilitated units tended to overlap with areas containing oxytocin.

    Peptide
    Oxytocin
    Outcome
    Not applicableDistribution of oxytocin-facilitated units
    Study

    ratn: not reported in source

    caudal brainstem neurones
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · microiontophoresisAs given in this study (rat).

    Source sentences

    Summary
    The distribution of units facilitated by oxytocin tended to overlap with the distribution of oxytocin demonstrated immunocytochemically, whereas many units inhibited by oxytocin were in regions where no oxytocin was observed.
    1 context sentence
    Summary · context
    The effects of microiontophoretically applied oxytocin on the firing rates of neurones in the rat caudal brainstem have been examined.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rat caudal brainstem neurones, many oxytocin-inhibited units were in regions where no oxytocin was observed.

    In plain wordsIn rat brainstem nerve cells, many oxytocin-inhibited units were in regions without observed oxytocin.

    Peptide
    Oxytocin
    Outcome
    Not applicableDistribution of oxytocin-inhibited units
    Study

    ratn: not reported in source

    caudal brainstem neurones
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · microiontophoresisAs given in this study (rat).

    Source sentences

    Summary
    The distribution of units facilitated by oxytocin tended to overlap with the distribution of oxytocin demonstrated immunocytochemically, whereas many units inhibited by oxytocin were in regions where no oxytocin was observed.
    1 context sentence
    Summary · context
    The effects of microiontophoretically applied oxytocin on the firing rates of neurones in the rat caudal brainstem have been examined.

Studies that did not test the peptide alone2

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 06AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism

    In rat caudal brainstem neurones, oxytocin and vasotocin antagonist analogues blocked oxytocin's excitatory effects.

    In plain wordsIn rat brainstem nerve cells, oxytocin and vasotocin antagonist analogues blocked oxytocin's excitatory effects.

    Peptide
    Oxytocin
    Outcome
    DecreaseAntagonist blockade of oxytocin excitatory effects
    Study

    ratn: not reported in source

    caudal brainstem neurones
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    Overall the excitatory but not the inhibitory effects of oxytocin could be blocked by oxytocin and vasotocin analogues with antagonist properties.
    1 context sentence
    Summary · context
    The effects of microiontophoretically applied oxytocin on the firing rates of neurones in the rat caudal brainstem have been examined.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 07AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism

    In rat caudal brainstem neurones, oxytocin and vasotocin antagonist analogues did not block oxytocin's inhibitory effects.

    In plain wordsIn rat brainstem nerve cells, oxytocin and vasotocin antagonist analogues did not block oxytocin's inhibitory effects.

    Peptide
    Oxytocin
    Outcome
    No significant changeAntagonist blockade of oxytocin inhibitory effects
    Study

    ratn: not reported in source

    caudal brainstem neurones
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    Overall the excitatory but not the inhibitory effects of oxytocin could be blocked by oxytocin and vasotocin analogues with antagonist properties.
    1 context sentence
    Summary · context
    The effects of microiontophoretically applied oxytocin on the firing rates of neurones in the rat caudal brainstem have been examined.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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