Delta sleep-inducing peptide (DSIP)-like material exists in peripheral organs of rats in large dissociable forms.

Graf MV, Kastin AJ

Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)1 Oct 1984Cited by 9 (Europe PMC)

PMID6548030DOI10.3181/00379727-177-41932PepBankPUB-06548030

Publisher page PubMedAsk about this study

Jump to 6 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01AnimalEndogenous levelAnimal study (in vivo)Other
In rats, DSIP-like immunoreactive material in 12 peripheral tissues ranged from 86 pg/mg in muscle to 849 pg/mg in stomach.
In plain wordsIn rats, material like the body's own DSIP was found in many organs, from muscle (lowest) to stomach (highest).
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
Not applicableDSIP-like immunoreactivity in peripheral organs
Study
ratn: not reported in source
rat peripheral tissue extracts, RIA
Outcome group
Endogenous peptide levels · Whole body
Measurements
DSIP-like immunoreactivity
86 to 849 pg/mg tissue
muscle (lowest) to stomach (highest)
Source sentences
Summary
Tissue from 12 areas was extracted with water, and the amounts of immunoreactive material found to be between 86 pg/mg tissue (muscle) and 849 pg/mg (stomach).
1 context sentence(design, population, supporting numbers)
Summary · context
We now describe the occurrence of DSIP-like material in the peripheral organs of the rat as measured by RIA.
This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0654803001
02AnimalEndogenous levelAnimal study (in vivo)Other
In rat tissue extracts, most DSIP-like immunoreactive material was larger than DSIP on Sephadex G-15 and G-25 chromatography.
In plain wordsIn rat tissue extracts, most of the body's own DSIP-like material was larger than the DSIP peptide itself.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
Not applicableSize of DSIP-like material on gel chromatography
Study
ratn: not reported in source
rat peripheral tissue extracts, RIA
Outcome group
Endogenous peptide levels · Whole body
Source sentences
Summary
Chromatography on columns of Sephadex G-15 and G-25 showed immunoreactive material mostly larger than DSIP.
1 context sentence(design, population, supporting numbers)
Summary · context
We now describe the occurrence of DSIP-like material in the peripheral organs of the rat as measured by RIA.
This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0654803002
03AnimalEndogenous levelAnimal study (in vivo)Other
In rat tissue extracts, trypsin digestion produced small immunoreactive peptides with only a minimal reduction in total immunoreactivity.
In plain wordsIn rat tissue extracts, trypsin broke the body's own large DSIP-like material into small peptides that were still detected.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
No significant changeEffect of trypsin digestion on DSIP-like immunoreactivity
Study
ratn: not reported in source
rat peripheral tissue extracts, RIA
Outcome group
Endogenous peptide levels · Whole body
Source sentences
Summary
Digestion with trypsin, however, produced small immunoreactive peptides with only a minimal reduction in total immunoreactivity.
1 context sentence(design, population, supporting numbers)
Summary · context
We now describe the occurrence of DSIP-like material in the peripheral organs of the rat as measured by RIA.
This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0654803003

Studies that did not test the peptide alone3

In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Delta sleep-inducing peptide (DSIP).

04AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Other
In an RIA of rat tissue extracts, about 80% of added DSIP was recovered at tissue concentrations of 1 mg/ml or less.
In plain wordsIn a lab assay on rat tissue extracts, about 80% of added DSIP was recovered at low tissue concentrations.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
Not applicableAssay recovery of added DSIP
Study
ratn: not reported in source
rat peripheral tissue extracts, RIA
Outcome group
Endogenous peptide levels · Whole body
Measurements
Recovery of added DSIP
≈ 80%
tissue concentrations of 1 mg/ml or less
Source sentences
Summary
Recoveries of about 80% of added DSIP were achieved at tissue concentrations of 1 mg/ml or less.
1 context sentence(design, population, supporting numbers)
Summary · context
We now describe the occurrence of DSIP-like material in the peripheral organs of the rat as measured by RIA.
In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).
Report a problemFND-0654803004
05AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Other
In an RIA of rat liver extracts, recovery of added DSIP fell at higher tissue concentrations.
In plain wordsIn a lab assay on rat liver extracts, less of the added DSIP was recovered at higher tissue concentrations.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseAssay recovery of added DSIP in liver at higher concentrations
Study
ratn: not reported in source
rat peripheral tissue extracts, RIA
Outcome group
Endogenous peptide levels · Whole body
Source sentences
Summary
This percentage was reduced in liver at higher concentrations.
1 context sentence(design, population, supporting numbers)
Summary · context
We now describe the occurrence of DSIP-like material in the peripheral organs of the rat as measured by RIA.
In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).
Report a problemFND-0654803005
06AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Other
In rat tissue extracts, the percentage of small peptide adsorbed by charcoal rose greatly at lower tissue concentrations, a significant linear effect.
In plain wordsIn rat tissue extracts, charcoal bound more of the small peptide when tissue concentrations were lower.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseAdsorption of small peptide by charcoal at lower tissue concentrations
Study
ratn: not reported in source
rat peripheral tissue extracts, RIA
Outcome group
Endogenous peptide levels · Whole body
Source sentences
Summary
The percentage of small peptide adsorbed by charcoal was greatly increased at lower tissue concentrations in all organs. This effect was significant and linear.
1 context sentence(design, population, supporting numbers)
Summary · context
We now describe the occurrence of DSIP-like material in the peripheral organs of the rat as measured by RIA.
In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).
Report a problemFND-0654803006

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

PepBank is a research reference. Talk to a doctor before you use any peptide.