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Study · Measured the body's own peptide · 1984

9 results

Presence of delta-sleep-inducing peptide-like material in human milk.

Graf MV, Hunter CA, Kastin AJ

The Journal of clinical endocrinology and metabolism1 Jul 1984Cited by 22 (Europe PMC)

PMID6547144 (opens in a new tab)DOI10.1210/jcem-59-1-127 (opens in a new tab)PepBankPUB-06547144
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

No result from this study comes from a test of the peptide.

Natural levels measured9

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In two women, DSIP-like material was detected in human breast milk by radioimmunoassay.

    In plain wordsIn two women, the body's own DSIP-like material was found in breast milk.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableDSIP-like immunoreactivity detected in human breast milk
    Study

    n = 2

    Outcome group
    Sleep · Sleep

    Source sentences

    Summary
    Delta-sleep-inducing peptide (DSIP)-like material was detected in human breast milk of two women by RIA with a recovery of about 90%.

    This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    In breast milk, DSIP-like immunoreactivity fell from about 30 ng/ml in colostrum to about 10 ng/ml in milk.

    In plain wordsThe body's own DSIP-like material in breast milk was lower in milk than in colostrum.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseDSIP-like immunoreactivity, colostrum versus milk
    Study

    n = 2

    Outcome group
    Sleep · Sleep

    Measurements

    DSIP-LI concentration
    30 ng/ml
    colostrum
    DSIP-LI concentration
    ≈ 10 ng/ml
    milk

    Source sentences

    Summary
    The high concentration of DSIP-like immunoreactivity (DSIP-LI) in colostrum (30 ng/ml) decreased to about 10 ng/ml in milk.

    This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelObservational studyMechanism

    Most DSIP-like immunoreactivity in milk and colostrum occurred in a form larger than the nonapeptide, and HPLC demonstrated DSIP itself.

    In plain wordsMost of the body's own DSIP-like levels in milk came as a form larger than DSIP itself, but DSIP was also found.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableMolecular forms of DSIP-like immunoreactivity in milk
    Study

    n = 2

    Outcome group
    Sleep · Sleep

    Source sentences

    Summary
    Gel chromatography revealed that most of the immunoreactive DSIP-LI in milk and colostrum occurred in a form larger than the nonapeptide.
    1 context sentence
    Summary · context
    The presence of DSIP itself, however, was demonstrated by high pressure liquid chromatography, which also showed additional peptides reacting with the antibody.

    This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.

  4. 04HumanEndogenous levelObservational studyMechanism

    Trypsin digestion of the large immunoreactive material produced a peak that coeluted with DSIP and held three immunoreactive fractions similar to DSIP, phosphorylated DSIP and N-tyrosine-DSIP.

    In plain wordsCutting the body's own large DSIP-like material in milk with an enzyme released pieces that behaved like DSIP and its modified forms.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableTrypsin digestion of large DSIP-like material
    Study

    n = 2

    Outcome group
    Sleep · Sleep

    Source sentences

    Summary
    Digestion of the large immunoreactive DSIP-LI by trypsin produced a peak on Sephadex G-10 that coeluted with DSIP.
    1 context sentence
    Summary · context
    This peak contained three immunoreactive fractions with retention times on high pressure liquid chromatography similar to DSIP, phosphorylated DSIP, and N-tyrosine-DSIP.

    This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.

  5. 05HumanEndogenous levelObservational studyOther

    In one woman, milk DSIP-like immunoreactivity kept decreasing over the next 2 months.

    In plain wordsIn one woman, the body's own DSIP-like material in milk kept falling over two months.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseMilk DSIP-like immunoreactivity over two months
    Study

    n = 1

    Outcome group
    Sleep · Sleep

    Source sentences

    Summary
    The concentration continued to decrease over the next 2 months in one women.

    This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.

  6. 06HumanEndogenous levelObservational studyOther

    In one woman, breast milk DSIP showed a significant circadian rhythm with a peak in the afternoon and a trough in the morning.

    In plain wordsIn one woman, the body's own DSIP in milk followed a daily rhythm, highest in the afternoon and lowest in the morning.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    MixedCircadian rhythm of milk DSIP
    Study

    n = 1

    Outcome group
    Sleep · Sleep

    Source sentences

    Summary
    In the same woman, a significant circadian rhythm of the amount of breast milk DSIP was found with the peak in the afternoon and the trough in the morning.

    This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.

  7. 07HumanEndogenous levelObservational studyOther

    In the other woman, milk DSIP-like immunoreactivity was lower before nursing and higher after nursing.

    In plain wordsIn one woman, the body's own DSIP-like material in milk was lower before nursing and higher after.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    MixedEffect of nursing on milk DSIP-like immunoreactivity
    Study

    n = 1

    Outcome group
    Sleep · Sleep

    Source sentences

    Summary
    A significant effect of the sampling procedure was detected in the other woman examined; lower amounts of DSIP-LI were found when the milk was collected before and higher concentrations after nursing.

    This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.

  8. 08HumanEndogenous levelObservational studyOther

    Plasma DSIP during pregnancy did not differ from normal values.

    In plain wordsThe body's own DSIP in blood during pregnancy was not different from normal values.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changePlasma DSIP during pregnancy
    Study

    n: not reported in source

    Comparator
    Normal values
    Outcome group
    Sleep · Sleep

    Source sentences

    Summary
    Plasma samples taken during pregnancy were assayed for DSIP but no difference from normal values was found.

    This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.

  9. 09HumanEndogenous levelObservational studyOther

    Slightly higher DSIP amounts were found in placenta than in blood, possibly because of interfering substances.

    In plain wordsSlightly more of the body's own DSIP-like material was found in placenta than in blood.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseDSIP in placenta versus blood
    Study

    n: not reported in source

    Comparator
    Blood
    Outcome group
    Sleep · Sleep

    Source sentences

    Summary
    Slightly higher amounts were found in placenta than in blood, which might be due to interfering substances.

    This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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