Effects of oxytocin and a derivative (Z-prolyl-D-leucine) on morphine tolerance/withdrawal are mediated by the limbic system.

Kovács GL, Izbéki F, Horváth Z, Telegdy G

Behavioural brain research1 Oct 1984Cited by 32 (Europe PMC)

PMID6542796DOI10.1016/0166-4328(84)90014-7PepBankPUB-06542796

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study16

14 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In mice, intracerebroventricular oxytocin (50 ng) attenuated morphine tolerance.
In plain wordsIn mice, oxytocin injected into a brain ventricle reduced morphine tolerance.
Peptide
Oxytocin
Outcome
DecreaseMorphine tolerance
Study
mousen: not reported in source
mouse
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
50 ng · intracerebroventricular injectionAs given in this study (mouse).
Source sentences
Summary
The present results confirm this hypothesis, since intracerebroventricular (i.c.v., 50 ng) and local (0.5 ng) injections of OXT and Z-Pro-D-Leu into the dorsal hippocampus and the mesolimbic nucleus accumbens attenuate morphine tolerance/dependence, similarly to systemic injections of these peptides…
1 context sentence(design, population, supporting numbers)
Summary · context
Recent data indicate that the neurohypophyseal hormone oxytocin (OXT) and Z-prolyl-D-leucine (Z-Pro-D-Leu), a synthetic dipeptide derived from the C-terminal part of OXT, attenuate the development of tolerance to and dependence on morphine in the mouse.
Report a problemFND-0654279601
02AnimalAnimal study (in vivo)Efficacy outcome
In mice, intracerebroventricular oxytocin (50 ng) attenuated morphine dependence.
In plain wordsIn mice, oxytocin injected into a brain ventricle reduced morphine dependence.
Peptide
Oxytocin
Outcome
DecreaseMorphine dependence
Study
mousen: not reported in source
mouse
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
50 ng · intracerebroventricular injectionAs given in this study (mouse).
Source sentences
Summary
The present results confirm this hypothesis, since intracerebroventricular (i.c.v., 50 ng) and local (0.5 ng) injections of OXT and Z-Pro-D-Leu into the dorsal hippocampus and the mesolimbic nucleus accumbens attenuate morphine tolerance/dependence, similarly to systemic injections of these peptides…
1 context sentence(design, population, supporting numbers)
Summary · context
Recent data indicate that the neurohypophyseal hormone oxytocin (OXT) and Z-prolyl-D-leucine (Z-Pro-D-Leu), a synthetic dipeptide derived from the C-terminal part of OXT, attenuate the development of tolerance to and dependence on morphine in the mouse.
Report a problemFND-0654279602
03AnimalAnimal study (in vivo)Efficacy outcome
In mice, oxytocin injection into the nucleus caudatus had no effect on morphine tolerance.
In plain wordsIn mice, oxytocin injected into the nucleus caudatus did not affect morphine tolerance.
Peptide
Oxytocin
Outcome
No significant changeMorphine tolerance after nucleus caudatus injection
Study
mousen: not reported in source
mouse
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated · local injection into the nucleus caudatusAs given in this study (mouse).
Source sentences
Summary
Local injections of these peptides into other brain sites (e.g. the nucleus caudatus, ventral tegmental area and the external cortical surface) are without effect.
2 context sentences(design, population, supporting numbers)
Summary · context
The present results confirm this hypothesis, since intracerebroventricular (i.c.v., 50 ng) and local (0.5 ng) injections of OXT and Z-Pro-D-Leu into the dorsal hippocampus and the mesolimbic nucleus accumbens attenuate morphine tolerance/dependence, similarly to systemic injections of these peptides…
Summary · context
Recent data indicate that the neurohypophyseal hormone oxytocin (OXT) and Z-prolyl-D-leucine (Z-Pro-D-Leu), a synthetic dipeptide derived from the C-terminal part of OXT, attenuate the development of tolerance to and dependence on morphine in the mouse.
Report a problemFND-0654279603
04AnimalAnimal study (in vivo)Efficacy outcome
In mice, oxytocin injection into the nucleus caudatus had no effect on morphine dependence.
In plain wordsIn mice, oxytocin injected into the nucleus caudatus did not affect morphine dependence.
Peptide
Oxytocin
Outcome
No significant changeMorphine dependence after nucleus caudatus injection
Study
mousen: not reported in source
mouse
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated · local injection into the nucleus caudatusAs given in this study (mouse).
Source sentences
Summary
Local injections of these peptides into other brain sites (e.g. the nucleus caudatus, ventral tegmental area and the external cortical surface) are without effect.
2 context sentences(design, population, supporting numbers)
Summary · context
The present results confirm this hypothesis, since intracerebroventricular (i.c.v., 50 ng) and local (0.5 ng) injections of OXT and Z-Pro-D-Leu into the dorsal hippocampus and the mesolimbic nucleus accumbens attenuate morphine tolerance/dependence, similarly to systemic injections of these peptides…
Summary · context
Recent data indicate that the neurohypophyseal hormone oxytocin (OXT) and Z-prolyl-D-leucine (Z-Pro-D-Leu), a synthetic dipeptide derived from the C-terminal part of OXT, attenuate the development of tolerance to and dependence on morphine in the mouse.
Report a problemFND-0654279604
05AnimalAnimal study (in vivo)Efficacy outcome
In mice, oxytocin injection into the dorsal hippocampus (0.5 ng) attenuated morphine tolerance.
In plain wordsIn mice, oxytocin injected into the dorsal hippocampus reduced morphine tolerance.
Peptide
Oxytocin
Outcome
DecreaseMorphine tolerance
Study
mousen: not reported in source
mouse
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
0.5 ng · local injection into the dorsal hippocampusAs given in this study (mouse).
Source sentences
Summary
The present results confirm this hypothesis, since intracerebroventricular (i.c.v., 50 ng) and local (0.5 ng) injections of OXT and Z-Pro-D-Leu into the dorsal hippocampus and the mesolimbic nucleus accumbens attenuate morphine tolerance/dependence, similarly to systemic injections of these peptides…
1 context sentence(design, population, supporting numbers)
Summary · context
Recent data indicate that the neurohypophyseal hormone oxytocin (OXT) and Z-prolyl-D-leucine (Z-Pro-D-Leu), a synthetic dipeptide derived from the C-terminal part of OXT, attenuate the development of tolerance to and dependence on morphine in the mouse.
Report a problemFND-0654279607
06AnimalAnimal study (in vivo)Efficacy outcome
In mice, oxytocin injection into the dorsal hippocampus (0.5 ng) attenuated morphine dependence.
In plain wordsIn mice, oxytocin injected into the dorsal hippocampus reduced morphine dependence.
Peptide
Oxytocin
Outcome
DecreaseMorphine dependence
Study
mousen: not reported in source
mouse
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
0.5 ng · local injection into the dorsal hippocampusAs given in this study (mouse).
Source sentences
Summary
The present results confirm this hypothesis, since intracerebroventricular (i.c.v., 50 ng) and local (0.5 ng) injections of OXT and Z-Pro-D-Leu into the dorsal hippocampus and the mesolimbic nucleus accumbens attenuate morphine tolerance/dependence, similarly to systemic injections of these peptides…
1 context sentence(design, population, supporting numbers)
Summary · context
Recent data indicate that the neurohypophyseal hormone oxytocin (OXT) and Z-prolyl-D-leucine (Z-Pro-D-Leu), a synthetic dipeptide derived from the C-terminal part of OXT, attenuate the development of tolerance to and dependence on morphine in the mouse.
Report a problemFND-0654279608
07AnimalAnimal study (in vivo)Efficacy outcome
In mice, oxytocin injection into the nucleus accumbens (0.5 ng) attenuated morphine tolerance.
In plain wordsIn mice, oxytocin injected into the nucleus accumbens reduced morphine tolerance.
Peptide
Oxytocin
Outcome
DecreaseMorphine tolerance
Study
mousen: not reported in source
mouse
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
0.5 ng · local injection into the nucleus accumbensAs given in this study (mouse).
Source sentences
Summary
The present results confirm this hypothesis, since intracerebroventricular (i.c.v., 50 ng) and local (0.5 ng) injections of OXT and Z-Pro-D-Leu into the dorsal hippocampus and the mesolimbic nucleus accumbens attenuate morphine tolerance/dependence, similarly to systemic injections of these peptides…
1 context sentence(design, population, supporting numbers)
Summary · context
Recent data indicate that the neurohypophyseal hormone oxytocin (OXT) and Z-prolyl-D-leucine (Z-Pro-D-Leu), a synthetic dipeptide derived from the C-terminal part of OXT, attenuate the development of tolerance to and dependence on morphine in the mouse.
Report a problemFND-0654279609
08AnimalAnimal study (in vivo)Efficacy outcome
In mice, oxytocin injection into the nucleus accumbens (0.5 ng) attenuated morphine dependence.
In plain wordsIn mice, oxytocin injected into the nucleus accumbens reduced morphine dependence.
Peptide
Oxytocin
Outcome
DecreaseMorphine dependence
Study
mousen: not reported in source
mouse
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
0.5 ng · local injection into the nucleus accumbensAs given in this study (mouse).
Source sentences
Summary
The present results confirm this hypothesis, since intracerebroventricular (i.c.v., 50 ng) and local (0.5 ng) injections of OXT and Z-Pro-D-Leu into the dorsal hippocampus and the mesolimbic nucleus accumbens attenuate morphine tolerance/dependence, similarly to systemic injections of these peptides…
1 context sentence(design, population, supporting numbers)
Summary · context
Recent data indicate that the neurohypophyseal hormone oxytocin (OXT) and Z-prolyl-D-leucine (Z-Pro-D-Leu), a synthetic dipeptide derived from the C-terminal part of OXT, attenuate the development of tolerance to and dependence on morphine in the mouse.
Report a problemFND-0654279610
09AnimalAnimal study (in vivo)Efficacy outcome
In mice, systemic oxytocin injection (5-50 micrograms) attenuated morphine tolerance.
In plain wordsIn mice, systemic oxytocin injection reduced morphine tolerance.
Peptide
Oxytocin
Outcome
DecreaseMorphine tolerance
Study
mousen: not reported in source
mouse
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
5-50 micrograms · systemic injectionAs given in this study (mouse).
Source sentences
Summary
The present results confirm this hypothesis, since intracerebroventricular (i.c.v., 50 ng) and local (0.5 ng) injections of OXT and Z-Pro-D-Leu into the dorsal hippocampus and the mesolimbic nucleus accumbens attenuate morphine tolerance/dependence, similarly to systemic injections of these peptides…
1 context sentence(design, population, supporting numbers)
Summary · context
Recent data indicate that the neurohypophyseal hormone oxytocin (OXT) and Z-prolyl-D-leucine (Z-Pro-D-Leu), a synthetic dipeptide derived from the C-terminal part of OXT, attenuate the development of tolerance to and dependence on morphine in the mouse.
Report a problemFND-0654279611
10AnimalAnimal study (in vivo)Efficacy outcome
In mice, systemic oxytocin injection (5-50 micrograms) attenuated morphine dependence.
In plain wordsIn mice, systemic oxytocin injection reduced morphine dependence.
Peptide
Oxytocin
Outcome
DecreaseMorphine dependence
Study
mousen: not reported in source
mouse
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
5-50 micrograms · systemic injectionAs given in this study (mouse).
Source sentences
Summary
The present results confirm this hypothesis, since intracerebroventricular (i.c.v., 50 ng) and local (0.5 ng) injections of OXT and Z-Pro-D-Leu into the dorsal hippocampus and the mesolimbic nucleus accumbens attenuate morphine tolerance/dependence, similarly to systemic injections of these peptides…
1 context sentence(design, population, supporting numbers)
Summary · context
Recent data indicate that the neurohypophyseal hormone oxytocin (OXT) and Z-prolyl-D-leucine (Z-Pro-D-Leu), a synthetic dipeptide derived from the C-terminal part of OXT, attenuate the development of tolerance to and dependence on morphine in the mouse.
Report a problemFND-0654279612
11AnimalAnimal study (in vivo)Efficacy outcome
In mice, oxytocin injection into the ventral tegmental area had no effect on morphine tolerance.
In plain wordsIn mice, oxytocin injected into the ventral tegmental area did not affect morphine tolerance.
Peptide
Oxytocin
Outcome
No significant changeMorphine tolerance after ventral tegmental area injection
Study
mousen: not reported in source
mouse
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated · local injection into the ventral tegmental areaAs given in this study (mouse).
Source sentences
Summary
Local injections of these peptides into other brain sites (e.g. the nucleus caudatus, ventral tegmental area and the external cortical surface) are without effect.
2 context sentences(design, population, supporting numbers)
Summary · context
The present results confirm this hypothesis, since intracerebroventricular (i.c.v., 50 ng) and local (0.5 ng) injections of OXT and Z-Pro-D-Leu into the dorsal hippocampus and the mesolimbic nucleus accumbens attenuate morphine tolerance/dependence, similarly to systemic injections of these peptides…
Summary · context
Recent data indicate that the neurohypophyseal hormone oxytocin (OXT) and Z-prolyl-D-leucine (Z-Pro-D-Leu), a synthetic dipeptide derived from the C-terminal part of OXT, attenuate the development of tolerance to and dependence on morphine in the mouse.
Report a problemFND-0654279613
12AnimalAnimal study (in vivo)Efficacy outcome
In mice, oxytocin injection into the external cortical surface had no effect on morphine tolerance.
In plain wordsIn mice, oxytocin injected onto the external cortical surface did not affect morphine tolerance.
Peptide
Oxytocin
Outcome
No significant changeMorphine tolerance after external cortical surface injection
Study
mousen: not reported in source
mouse
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated · local injection onto the external cortical surfaceAs given in this study (mouse).
Source sentences
Summary
Local injections of these peptides into other brain sites (e.g. the nucleus caudatus, ventral tegmental area and the external cortical surface) are without effect.
2 context sentences(design, population, supporting numbers)
Summary · context
The present results confirm this hypothesis, since intracerebroventricular (i.c.v., 50 ng) and local (0.5 ng) injections of OXT and Z-Pro-D-Leu into the dorsal hippocampus and the mesolimbic nucleus accumbens attenuate morphine tolerance/dependence, similarly to systemic injections of these peptides…
Summary · context
Recent data indicate that the neurohypophyseal hormone oxytocin (OXT) and Z-prolyl-D-leucine (Z-Pro-D-Leu), a synthetic dipeptide derived from the C-terminal part of OXT, attenuate the development of tolerance to and dependence on morphine in the mouse.
Report a problemFND-0654279614
13AnimalAnimal study (in vivo)Efficacy outcome
In mice, oxytocin injection into the ventral tegmental area had no effect on morphine dependence.
In plain wordsIn mice, oxytocin injected into the ventral tegmental area did not affect morphine dependence.
Peptide
Oxytocin
Outcome
No significant changeMorphine dependence after ventral tegmental area injection
Study
mousen: not reported in source
mouse
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated · local injection into the ventral tegmental areaAs given in this study (mouse).
Source sentences
Summary
Local injections of these peptides into other brain sites (e.g. the nucleus caudatus, ventral tegmental area and the external cortical surface) are without effect.
2 context sentences(design, population, supporting numbers)
Summary · context
The present results confirm this hypothesis, since intracerebroventricular (i.c.v., 50 ng) and local (0.5 ng) injections of OXT and Z-Pro-D-Leu into the dorsal hippocampus and the mesolimbic nucleus accumbens attenuate morphine tolerance/dependence, similarly to systemic injections of these peptides…
Summary · context
Recent data indicate that the neurohypophyseal hormone oxytocin (OXT) and Z-prolyl-D-leucine (Z-Pro-D-Leu), a synthetic dipeptide derived from the C-terminal part of OXT, attenuate the development of tolerance to and dependence on morphine in the mouse.
Report a problemFND-0654279615
14AnimalAnimal study (in vivo)Efficacy outcome
In mice, oxytocin injection into the external cortical surface had no effect on morphine dependence.
In plain wordsIn mice, oxytocin injected onto the external cortical surface did not affect morphine dependence.
Peptide
Oxytocin
Outcome
No significant changeMorphine dependence after external cortical surface injection
Study
mousen: not reported in source
mouse
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated · local injection onto the external cortical surfaceAs given in this study (mouse).
Source sentences
Summary
Local injections of these peptides into other brain sites (e.g. the nucleus caudatus, ventral tegmental area and the external cortical surface) are without effect.
2 context sentences(design, population, supporting numbers)
Summary · context
The present results confirm this hypothesis, since intracerebroventricular (i.c.v., 50 ng) and local (0.5 ng) injections of OXT and Z-Pro-D-Leu into the dorsal hippocampus and the mesolimbic nucleus accumbens attenuate morphine tolerance/dependence, similarly to systemic injections of these peptides…
Summary · context
Recent data indicate that the neurohypophyseal hormone oxytocin (OXT) and Z-prolyl-D-leucine (Z-Pro-D-Leu), a synthetic dipeptide derived from the C-terminal part of OXT, attenuate the development of tolerance to and dependence on morphine in the mouse.
Report a problemFND-0654279616

Studies that did not test the peptide alone2

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

15AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism
In mice, nucleus accumbens lesion partially prevented oxytocin's effect on morphine tolerance.
In plain wordsIn mice, a nucleus accumbens lesion partly prevented oxytocin's effect on morphine tolerance.
Peptide
Oxytocin
Outcome
DecreaseOxytocin effect on morphine tolerance after nucleus accumbens lesion
Study
mousen: not reported in source
mouse
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
Lesion of the nucleus accumbens by the catecholaminergic neurotoxin 6-hydroxydopamine (6-OHDA) completely prevents the effects of Z-Pro-D-Leu and partially those of OXT on morphine tolerance/dependence.
2 context sentences(design, population, supporting numbers)
Summary · context
The present results confirm this hypothesis, since intracerebroventricular (i.c.v., 50 ng) and local (0.5 ng) injections of OXT and Z-Pro-D-Leu into the dorsal hippocampus and the mesolimbic nucleus accumbens attenuate morphine tolerance/dependence, similarly to systemic injections of these peptides…
Summary · context
Recent data indicate that the neurohypophyseal hormone oxytocin (OXT) and Z-prolyl-D-leucine (Z-Pro-D-Leu), a synthetic dipeptide derived from the C-terminal part of OXT, attenuate the development of tolerance to and dependence on morphine in the mouse.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-0654279605
16AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism
In mice, nucleus accumbens lesion partially prevented oxytocin's effect on morphine dependence.
In plain wordsIn mice, a nucleus accumbens lesion partly prevented oxytocin's effect on morphine dependence.
Peptide
Oxytocin
Outcome
DecreaseOxytocin effect on morphine dependence after nucleus accumbens lesion
Study
mousen: not reported in source
mouse
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
Lesion of the nucleus accumbens by the catecholaminergic neurotoxin 6-hydroxydopamine (6-OHDA) completely prevents the effects of Z-Pro-D-Leu and partially those of OXT on morphine tolerance/dependence.
2 context sentences(design, population, supporting numbers)
Summary · context
The present results confirm this hypothesis, since intracerebroventricular (i.c.v., 50 ng) and local (0.5 ng) injections of OXT and Z-Pro-D-Leu into the dorsal hippocampus and the mesolimbic nucleus accumbens attenuate morphine tolerance/dependence, similarly to systemic injections of these peptides…
Summary · context
Recent data indicate that the neurohypophyseal hormone oxytocin (OXT) and Z-prolyl-D-leucine (Z-Pro-D-Leu), a synthetic dipeptide derived from the C-terminal part of OXT, attenuate the development of tolerance to and dependence on morphine in the mouse.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-0654279606

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 20:03 UTC
Study results updated
Version 1
9 Oct 2026, 02:53 UTC
First added · source update from Europe PMC

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