Neuropeptides related to neurohypophyseal hormones interfere with apomorphine-induced behavioral changes.

Xiao XS, Veldhuis HD, Van Ree JM

Neuropeptides1 May 1984Cited by 5 (Europe PMC)

PMID6540377DOI10.1016/0143-4179(84)90104-5PepBankPUB-06540377

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats, PLG did not interfere with behavioral responses to higher apomorphine doses.
In plain wordsIn rats, PLG did not change behavioral responses to higher doses of apomorphine.
Peptide
MIF-1 (Pro-Leu-Gly-NH2)
Outcome
No significant changeBehavioral responses to higher apomorphine doses
Study
ratn: not reported in source
Apomorphine-induced behavioral changes in rats
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Desglycinamide9[Arg8]vasopressin (DG-AVP), prolyl-leucyl-glycinamide (PLG) and oxytocin did not interfere with the behavioral responses induced by the higher doses of apomorphine.
2 context sentences(design, population, supporting numbers)
Summary · context
Low doses of this drug induce hypoactivity of the animals, while higher doses result in hyperactivity and stereotyped sniffing.
Summary · context
The interaction between peptides related to neurohypophyseal hormones and brain dopaminergic systems was studied by investigating in rats the effect of these peptides on behavioral changes induced by graded doses of the specific dopamine agonist apomorphine.
Report a problemFND-0654037701
02AnimalAnimal study (in vivo)Efficacy outcome
In rats, oxytocin did not interfere with behavioral responses to higher apomorphine doses.
In plain wordsIn rats, oxytocin did not change behavioral responses to higher doses of apomorphine.
Peptide
Oxytocin
Outcome
No significant changeBehavioral responses to higher apomorphine doses
Study
ratn: not reported in source
Apomorphine-induced behavioral changes in rats
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Desglycinamide9[Arg8]vasopressin (DG-AVP), prolyl-leucyl-glycinamide (PLG) and oxytocin did not interfere with the behavioral responses induced by the higher doses of apomorphine.
2 context sentences(design, population, supporting numbers)
Summary · context
Low doses of this drug induce hypoactivity of the animals, while higher doses result in hyperactivity and stereotyped sniffing.
Summary · context
The interaction between peptides related to neurohypophyseal hormones and brain dopaminergic systems was studied by investigating in rats the effect of these peptides on behavioral changes induced by graded doses of the specific dopamine agonist apomorphine.
Report a problemFND-0654037702
03AnimalAnimal study (in vivo)Efficacy outcome
In rats, PLG increased sensitivity to apomorphine-induced hypoactivity.
In plain wordsIn rats, PLG increased sensitivity to reduced activity caused by apomorphine.
Peptide
MIF-1 (Pro-Leu-Gly-NH2)
Outcome
IncreaseSensitivity to apomorphine-induced hypoactivity
Study
ratn: not reported in source
Apomorphine-induced behavioral changes in rats
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Peptide treatment made the rats more sensitive to apomorphine with respect to the drug induced hypoactivity.
2 context sentences(design, population, supporting numbers)
Summary · context
Desglycinamide9[Arg8]vasopressin (DG-AVP), prolyl-leucyl-glycinamide (PLG) and oxytocin did not interfere with the behavioral responses induced by the higher doses of apomorphine.
Summary · context
The interaction between peptides related to neurohypophyseal hormones and brain dopaminergic systems was studied by investigating in rats the effect of these peptides on behavioral changes induced by graded doses of the specific dopamine agonist apomorphine.
Report a problemFND-0654037703
04AnimalAnimal study (in vivo)Efficacy outcome
In rats, oxytocin increased sensitivity to apomorphine-induced hypoactivity.
In plain wordsIn rats, oxytocin increased sensitivity to reduced activity caused by apomorphine.
Peptide
Oxytocin
Outcome
IncreaseSensitivity to apomorphine-induced hypoactivity
Study
ratn: not reported in source
Apomorphine-induced behavioral changes in rats
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Peptide treatment made the rats more sensitive to apomorphine with respect to the drug induced hypoactivity.
2 context sentences(design, population, supporting numbers)
Summary · context
Desglycinamide9[Arg8]vasopressin (DG-AVP), prolyl-leucyl-glycinamide (PLG) and oxytocin did not interfere with the behavioral responses induced by the higher doses of apomorphine.
Summary · context
The interaction between peptides related to neurohypophyseal hormones and brain dopaminergic systems was studied by investigating in rats the effect of these peptides on behavioral changes induced by graded doses of the specific dopamine agonist apomorphine.
Report a problemFND-0654037704
05AnimalAnimal study (in vivo)Efficacy outcome
In rats, PLG increased sensitivity to apomorphine-induced hypoactivity more effectively than oxytocin.
In plain wordsIn rats, PLG increased sensitivity to apomorphine-induced reduced activity more than oxytocin.
Peptide
MIF-1 (Pro-Leu-Gly-NH2)
Outcome
IncreaseHypoactivity sensitization compared with oxytocin
Study
ratn: not reported in source
Apomorphine-induced behavioral changes in rats
Comparator
Oxytocin
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
PLG and especially DG-AVP were more effective than oxytocin.
2 context sentences(design, population, supporting numbers)
Summary · context
Peptide treatment made the rats more sensitive to apomorphine with respect to the drug induced hypoactivity.
Summary · context
The interaction between peptides related to neurohypophyseal hormones and brain dopaminergic systems was studied by investigating in rats the effect of these peptides on behavioral changes induced by graded doses of the specific dopamine agonist apomorphine.
Report a problemFND-0654037705
06AnimalAnimal study (in vivo)Efficacy outcome
In rats, oxytocin increased sensitivity to apomorphine-induced hypoactivity less effectively than PLG.
In plain wordsIn rats, oxytocin increased sensitivity to apomorphine-induced reduced activity less than PLG.
Peptide
Oxytocin
Outcome
DecreaseHypoactivity sensitization compared with PLG
Study
ratn: not reported in source
Apomorphine-induced behavioral changes in rats
Comparator
PLG
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
PLG and especially DG-AVP were more effective than oxytocin.
2 context sentences(design, population, supporting numbers)
Summary · context
Peptide treatment made the rats more sensitive to apomorphine with respect to the drug induced hypoactivity.
Summary · context
The interaction between peptides related to neurohypophyseal hormones and brain dopaminergic systems was studied by investigating in rats the effect of these peptides on behavioral changes induced by graded doses of the specific dopamine agonist apomorphine.
Report a problemFND-0654037706
07AnimalAnimal study (in vivo)Efficacy outcome
In rats, oxytocin increased sensitivity to apomorphine-induced hypoactivity less effectively than DG-AVP.
In plain wordsIn rats, oxytocin increased sensitivity to apomorphine-induced reduced activity less than DG-AVP.
Peptide
Oxytocin
Outcome
DecreaseHypoactivity sensitization compared with DG-AVP
Study
ratn: not reported in source
Apomorphine-induced behavioral changes in rats
Comparator
DG-AVP
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
PLG and especially DG-AVP were more effective than oxytocin.
2 context sentences(design, population, supporting numbers)
Summary · context
Peptide treatment made the rats more sensitive to apomorphine with respect to the drug induced hypoactivity.
Summary · context
The interaction between peptides related to neurohypophyseal hormones and brain dopaminergic systems was studied by investigating in rats the effect of these peptides on behavioral changes induced by graded doses of the specific dopamine agonist apomorphine.
Report a problemFND-0654037707

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 2
21 Oct 2026, 18:59 UTC
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 02:53 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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