Vasoactive intestinal peptide relaxes isolated strips of human bronchus, pulmonary artery, and lung parenchyma.

Saga T, Said SI

Transactions of the Association of American Physicians1 Jan 1984Cited by 44 (Europe PMC)

PMID6535346PepBankPUB-06535346

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

5 results from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueEfficacy outcome
VIP relaxed isolated strips of human bronchus in vitro.
In plain wordsIn lab tests on human lung tissue, VIP relaxed strips of bronchus (airway).
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseRelaxation of isolated human bronchus
Study
humann: not reported in source
isolated human lung tissue strips
Outcome group
Respiratory function · Respiratory
Studied dose
Dose not stated
Source sentences
Summary
VIP, an endogenous neuropeptide normally present in lungs and other organs, relaxes isolated strips of human bronchus, pulmonary artery, and lung parenchyma in vitro
Report a problemFND-0653534601
02LabEx vivo tissueEfficacy outcome
VIP relaxed isolated strips of human pulmonary artery in vitro.
In plain wordsIn lab tests on human lung tissue, VIP relaxed strips of pulmonary artery.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseRelaxation of isolated human pulmonary artery
Study
humann: not reported in source
isolated human lung tissue strips
Outcome group
Respiratory function · Respiratory
Studied dose
Dose not stated
Source sentences
Summary
VIP, an endogenous neuropeptide normally present in lungs and other organs, relaxes isolated strips of human bronchus, pulmonary artery, and lung parenchyma in vitro
Report a problemFND-0653534602
03LabEx vivo tissueEfficacy outcome
VIP relaxed isolated strips of human lung parenchyma in vitro.
In plain wordsIn lab tests on human lung tissue, VIP relaxed strips of lung parenchyma.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseRelaxation of isolated human lung parenchyma
Study
humann: not reported in source
isolated human lung tissue strips
Outcome group
Respiratory function · Respiratory
Studied dose
Dose not stated
Source sentences
Summary
VIP, an endogenous neuropeptide normally present in lungs and other organs, relaxes isolated strips of human bronchus, pulmonary artery, and lung parenchyma in vitro
Report a problemFND-0653534603
04LabEx vivo tissueActivity measurement
The VIP-induced relaxation of isolated human tissue, especially of pulmonary artery, had a long duration.
In plain wordsIn lab tests on human lung tissue, VIP relaxation lasted a long time, especially in the pulmonary artery.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableDuration of VIP-induced relaxation
Study
humann: not reported in source
isolated human lung tissue strips
Outcome group
Respiratory function · Respiratory
Studied dose
Dose not stated
Source sentences
Summary
The VIP-induced relaxation, especially of pulmonary artery, has a long duration.
Report a problemFND-0653534605
05LabEx vivo tissueActivity measurement
As a relaxant of human pulmonary arterial strip, VIP was approximately 200 times as potent as prostacyclin on a molar basis.
In plain wordsIn lab tests on human pulmonary artery tissue, VIP relaxed the artery with about 200 times the potency of prostacyclin.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseRelaxant potency in human pulmonary arterial strip versus prostacyclin
Study
humann: not reported in source
isolated human lung tissue strips
Comparator
Prostacyclin
Outcome group
Respiratory function · Respiratory
Studied dose
Dose not stated
Measurements
relative potency vs prostacyclin
≈ 200-fold
human pulmonary arterial strip
Source sentences
Summary
As a relaxant of human pulmonary arterial strip, VIP is approximately 200 times as potent as prostacyclin, on a molar basis.
Report a problemFND-0653534606

Studies that did not test the peptide alone1

In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).

06LabNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneEx vivo tissueEfficacy outcome
Pretreatment of isolated human lung tissues with indomethacin markedly enhanced the basal tone and the relaxant effect of VIP.
In plain wordsIn lab tests on human lung tissue, indomethacin pretreatment strengthened the relaxing effect of VIP.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseEffect of indomethacin on basal tone and VIP relaxation
Study
humann: not reported in source
isolated human lung tissue strips
Comparator
Untreated tissue
Outcome group
Respiratory function · Respiratory
Source sentences
Summary
Pretreatment of these tissues with indomethacin (1 micrograms/ml) markedly enhances the basal tone and the relaxant effect of VIP.
In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).
Report a problemFND-0653534604

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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