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Study · Not a test of the peptide alone · 1984

2 results

Antispasmodic effects of an alkaloid extracted from Phyllanthus sellowianus: a comparative study with papaverine.

Calixto JB, Yunes RA, Neto AS, Valle RM, Rae GA

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas1 Jan 1984Cited by 18 (Europe PMC)

PMID6529614 (opens in a new tab)PepBankPUB-06529614
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 01LabNot a test of Oxytocin aloneEx vivo tissueOther

    In rat uterine strips, ALK-1 flattened the dose-response curve to oxytocin.

    In plain wordsIn lab tests of rat uterine strips, ALK-1 flattened the response to oxytocin.

    Peptide
    Oxytocin
    Outcome
    DecreaseOxytocin dose-response curve after ALK-1
    Study

    ratn: not reported in source

    uterine strips
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    ALK-1 and papaverine promoted a dose-dependent flattening of the dose-response curves obtained to acetylcholine and histamine on ileum strips and of the dose-response curves to acetylcholine and oxytocin on uterine strips.
    1 context sentence
    Summary · context
    This study describes the isolation of an alkaloid from P. sellowianus, denoted ALK-1, and compares its antipasmodic activity with that of papaverine on isolated strips of guinea pig ileum and rat uterus, and rat aorta rings.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 02LabNot a test of Oxytocin aloneEx vivo tissueActivity measurement

    In rat uterine strips, papaverine flattened the dose-response curve to oxytocin.

    In plain wordsIn lab tests of rat uterine strips, papaverine flattened the response to oxytocin.

    Peptide
    Oxytocin
    Outcome
    DecreaseOxytocin dose-response curve after papaverine
    Study

    ratn: not reported in source

    rat uterine strips
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    ALK-1 and papaverine promoted a dose-dependent flattening of the dose-response curves obtained to acetylcholine and histamine on ileum strips and of the dose-response curves to acetylcholine and oxytocin on uterine strips.
    1 context sentence
    Summary · context
    This study describes the isolation of an alkaloid from P. sellowianus, denoted ALK-1, and compares its antipasmodic activity with that of papaverine on isolated strips of guinea pig ileum and rat uterus, and rat aorta rings.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:54 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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