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Study · Animal study (in vivo) · rat · 1984

3 results

Dermorphin, a new peptide from amphibian skin, inhibits the nociceptive thalamic neurons firing rate evoked by noxious stimuli.

Braga PC, Tiengo M, Biella G, Dall'Oglio G, Fraschini F

Neuroscience letters1 Nov 1984Cited by 10 (Europe PMC)

PMID6527833 (opens in a new tab)DOI10.1016/0304-3940(84)90368-9 (opens in a new tab)PepBankPUB-06527833
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, dermorphin blocked the high thalamic firing frequency induced by nociceptive stimuli.

    In plain wordsIn rats, dermorphin blocked rapid thalamic nerve firing induced by painful stimuli.

    Peptide
    Dermorphin
    Outcome
    DecreaseNociceptive neuronal firing
    Study

    ratn: not reported in source

    thalamic nociceptive neuronal activity
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    1.5 mg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    The high firing frequency induced by nociceptive stimuli was blocked when dermorphin was injected intraperitoneally at the dose of 1.5 mg/kg.
    1 context sentence
    Summary · context
    The effect of dermorphin on the spontaneous and evoked neuronal activity by a nociceptive stimulus was studied in the nucleus lateralis anterior and ventrobasal complex of the rat thalamus.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, dermorphin's neuronal effect began about 10 min after injection and lasted an average of 120 min.

    In plain wordsIn rats, dermorphin's nerve effect began about 10 min after injection and lasted an average of 120 min.

    Peptide
    Dermorphin
    Outcome
    Not applicableOnset and duration of neuronal effect
    Study

    ratn: not reported in source

    thalamic nociceptive neuronal activity
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    1.5 mg/kg · intraperitonealAs given in this study (rat).

    Measurements

    Onset
    ≈ 10 min
    after injection
    Duration
    120 min
    average

    Source sentences

    Summary
    The action starts about 10 min after injection and lasts on average for 120 min.
    2 context sentences
    Summary · context
    The high firing frequency induced by nociceptive stimuli was blocked when dermorphin was injected intraperitoneally at the dose of 1.5 mg/kg.
    Summary · context
    The effect of dermorphin on the spontaneous and evoked neuronal activity by a nociceptive stimulus was studied in the nucleus lateralis anterior and ventrobasal complex of the rat thalamus.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats, dermorphin's time-course was about twice that of morphine under the same experimental conditions.

    In plain wordsIn rats, dermorphin's effect lasted about twice as long as morphine's under the same conditions.

    Peptide
    Dermorphin
    Outcome
    IncreaseNeuronal effect time-course versus morphine
    Study

    ratn: not reported in source

    thalamic nociceptive neuronal activity
    Comparator
    morphine (1.5 mg/kg i.p.)
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    1.5 mg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    The dermorphin time-course is about twice that of morphine (1.5 mg/kg i.p.) under the same experimental conditions.
    1 context sentence
    Summary · context
    The effect of dermorphin on the spontaneous and evoked neuronal activity by a nociceptive stimulus was studied in the nucleus lateralis anterior and ventrobasal complex of the rat thalamus.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

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Terms as the source lists them.

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