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Study · Animal study (in vivo) · rat · 1984

5 results

Distribution and metabolism of dermorphin in rats.

Negri L, Improta G

Pharmacological research communications1 Dec 1984Cited by 26 (Europe PMC)

PMID6522442 (opens in a new tab)DOI10.1016/s0031-6989(84)80083-1 (opens in a new tab)PepBankPUB-06522442
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Pharmacokinetics

    In rats, dermorphin rapidly disappeared from plasma with a half-life of 1.3 min.

    In plain wordsIn rats, dermorphin rapidly disappeared from blood plasma with a half-life of 1.3 min.

    Peptide
    Dermorphin
    Outcome
    DecreasePlasma disappearance half-life
    Study

    ratn: not reported in source

    dermorphin distribution and metabolism
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Measurements

    Plasma half-life
    1.3 min
    rats

    Source sentences

    Summary
    Dermorphin rapidly disappeared from plasma (half-life: 1.3 min).
    1 context sentence
    Summary · context
    Dermorphin distribution and metabolism were studied in rats injected with high doses of the peptide and with 125I-dermorphin, using RIA methods, HPLC extraction and -counting.
  2. 02AnimalAnimal study (in vivo)Pharmacokinetics

    In rats, in vivo experiments showed dermorphin degradation in liver and kidney.

    In plain wordsIn rats, dermorphin underwent breakdown in liver and kidney.

    Peptide
    Dermorphin
    Outcome
    Not applicableLiver and kidney degradation
    Study

    ratn: not reported in source

    dermorphin distribution and metabolism
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vivo and in vitro experiments demonstrated that the peptide was destroyed in liver and kidney.
    1 context sentence
    Summary · context
    Dermorphin distribution and metabolism were studied in rats injected with high doses of the peptide and with 125I-dermorphin, using RIA methods, HPLC extraction and -counting.
  3. 03AnimalAnimal study (in vivo)Pharmacokinetics

    In rats, bile collected over 1 hour contained the highest recovered percentage of injected dermorphin, 11%.

    In plain wordsIn rats, bile collected over 1 hour contained 11% of injected dermorphin, the highest recovered percentage.

    Peptide
    Dermorphin
    Outcome
    Not applicableBiliary recovery
    Study

    ratn: not reported in source

    dermorphin distribution and metabolism
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Measurements

    Injected dermorphin recovered in bile
    11%
    bile collected over 1 hour

    Source sentences

    Summary
    The highest percent (11%) of injected dermorphin has been found in the bile collected over 1 hour.
    1 context sentence
    Summary · context
    Dermorphin distribution and metabolism were studied in rats injected with high doses of the peptide and with 125I-dermorphin, using RIA methods, HPLC extraction and -counting.
  4. 04AnimalAnimal study (in vivo)Pharmacokinetics

    In rats, bile contained dermorphin breakdown products comprising di-, tri-, and tetra-N-terminal fragments.

    In plain wordsIn rats, bile contained dermorphin breakdown products with short N-terminal peptide fragments.

    Peptide
    Dermorphin
    Outcome
    Not applicableBiliary breakdown products
    Study

    ratn: not reported in source

    dermorphin distribution and metabolism
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HPLC analysis showed that bile contained also breakdown products (di, tri, and tetra N-terminal peptide fragments).
    1 context sentence
    Summary · context
    Dermorphin distribution and metabolism were studied in rats injected with high doses of the peptide and with 125I-dermorphin, using RIA methods, HPLC extraction and -counting.
  5. 05LabEx vivo tissuePharmacokinetics

    In vitro experiments showed dermorphin degradation in liver and kidney.

    In plain wordsIn lab tests, dermorphin underwent breakdown in liver and kidney.

    Peptide
    Dermorphin
    Outcome
    Not applicableLiver and kidney degradation in vitro
    Study

    ratn: not reported in source

    liver and kidney in vitro
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vivo and in vitro experiments demonstrated that the peptide was destroyed in liver and kidney.
    1 context sentence
    Summary · context
    Dermorphin distribution and metabolism were studied in rats injected with high doses of the peptide and with 125I-dermorphin, using RIA methods, HPLC extraction and -counting.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

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