Dermorphin stimulates prolactin secretion in the rat.

Giudici D, D'Urso R, Falaschi P, Negri L, Melchiorri P, Motta M

Neuroendocrinology1 Sept 1984Cited by 9 (Europe PMC)

PMID6504268DOI10.1159/000123985PepBankPUB-06504268

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In normal male rats, subcutaneous dermorphin significantly increased serum prolactin in a dose-related manner.
In plain wordsIn male rats, dermorphin injections under the skin increased prolactin with a dose-related effect.
Peptide
Dermorphin
Outcome
IncreaseSerum prolactin after subcutaneous administration
Study
ratn: not reported in source
normal male rats
Outcome group
Pituitary hormones · Endocrine and hormones
Studied dose
0.1 to 5 mg/kg body weight · subcutaneousAs given in this study (rat).
Source sentences
Summary
In vivo experiments: subcutaneous administrations of different doses of dermorphin ranging from 0.1 to 5 mg/kg body weight to normal male rats induce a statistically significant, dose-related increase in serum Prl levels.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of dermorphin, a new opioid peptide originally isolated from amphibian skin, on the release of prolactin (Prl) was studied in vivo and in vitro.
Report a problemFND-0650426801
02AnimalAnimal study (in vivo)Efficacy outcome
In normal male rats, dermorphin did not significantly change serum prolactin at 10 min with the lower intraventricular dose.
In plain wordsIn male rats, the lower dermorphin dose into a brain ventricle did not significantly change prolactin at 10 min.
Peptide
Dermorphin
Outcome
No significant changeSerum prolactin at 10 min with lower intraventricular dose
Study
ratn: not reported in source
normal male rats
Outcome group
Pituitary hormones · Endocrine and hormones
Studied dose
0.25 micrograms/kg · intraventricularAs given in this study (rat).
Source sentences
Summary
In normal male rats, the intraventricular injection of 0.25 micrograms/kg of dermorphin is not able to induce any significant changes in serum Prl levels 10 min after injection.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of dermorphin, a new opioid peptide originally isolated from amphibian skin, on the release of prolactin (Prl) was studied in vivo and in vitro.
Report a problemFND-0650426802
03AnimalAnimal study (in vivo)Efficacy outcome
In normal male rats, serum prolactin significantly increased 30 min after the lower intraventricular dermorphin dose.
In plain wordsIn male rats, the lower dermorphin dose into a brain ventricle increased prolactin at 30 min.
Peptide
Dermorphin
Outcome
IncreaseSerum prolactin at 30 min with lower intraventricular dose
Study
ratn: not reported in source
normal male rats
Outcome group
Pituitary hormones · Endocrine and hormones
Studied dose
0.25 micrograms/kg · intraventricularAs given in this study (rat).
Source sentences
Summary
Serum Prl levels show a significant enhancement 30 min after the administration of this dose of dermorphin, and return to control values at 60 min.
2 context sentences(design, population, supporting numbers)
Summary · context
In normal male rats, the intraventricular injection of 0.25 micrograms/kg of dermorphin is not able to induce any significant changes in serum Prl levels 10 min after injection.
Summary · context
The effect of dermorphin, a new opioid peptide originally isolated from amphibian skin, on the release of prolactin (Prl) was studied in vivo and in vitro.
Report a problemFND-0650426803
04AnimalAnimal study (in vivo)Efficacy outcome
In normal male rats, prolactin returned to control values 60 min after the lower intraventricular dermorphin dose.
In plain wordsIn male rats, prolactin returned to control values 60 min after the lower dermorphin dose into a brain ventricle.
Peptide
Dermorphin
Outcome
No significant changeSerum prolactin at 60 min with lower intraventricular dose
Study
ratn: not reported in source
normal male rats
Comparator
control values
Outcome group
Pituitary hormones · Endocrine and hormones
Studied dose
0.25 micrograms/kg · intraventricularAs given in this study (rat).
Source sentences
Summary
Serum Prl levels show a significant enhancement 30 min after the administration of this dose of dermorphin, and return to control values at 60 min.
2 context sentences(design, population, supporting numbers)
Summary · context
In normal male rats, the intraventricular injection of 0.25 micrograms/kg of dermorphin is not able to induce any significant changes in serum Prl levels 10 min after injection.
Summary · context
The effect of dermorphin, a new opioid peptide originally isolated from amphibian skin, on the release of prolactin (Prl) was studied in vivo and in vitro.
Report a problemFND-0650426804
05AnimalAnimal study (in vivo)Efficacy outcome
In normal male rats, intraventricular dermorphin significantly increased prolactin at 10 min with the higher dose.
In plain wordsIn male rats, the higher dermorphin dose into a brain ventricle increased prolactin at 10 min.
Peptide
Dermorphin
Outcome
IncreaseSerum prolactin at 10 min with higher intraventricular dose
Study
ratn: not reported in source
normal male rats
Outcome group
Pituitary hormones · Endocrine and hormones
Studied dose
1 microgram/kg · intraventricularAs given in this study (rat).
Source sentences
Summary
On the contrary, 1 microgram/kg of dermorphin significantly elevates Prl concentrations 10 min after injection, leaving serum Prl levels unchanged 30 and 60 min after the administration.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of dermorphin, a new opioid peptide originally isolated from amphibian skin, on the release of prolactin (Prl) was studied in vivo and in vitro.
Report a problemFND-0650426805
06AnimalAnimal study (in vivo)Efficacy outcome
In normal male rats, the higher intraventricular dermorphin dose left prolactin unchanged at 30 and 60 min.
In plain wordsIn male rats, the higher dermorphin dose into a brain ventricle left prolactin unchanged at 30 and 60 min.
Peptide
Dermorphin
Outcome
No significant changeSerum prolactin at 30 and 60 min with higher intraventricular dose
Study
ratn: not reported in source
normal male rats
Outcome group
Pituitary hormones · Endocrine and hormones
Studied dose
1 microgram/kg · intraventricularAs given in this study (rat).
Source sentences
Summary
On the contrary, 1 microgram/kg of dermorphin significantly elevates Prl concentrations 10 min after injection, leaving serum Prl levels unchanged 30 and 60 min after the administration.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of dermorphin, a new opioid peptide originally isolated from amphibian skin, on the release of prolactin (Prl) was studied in vivo and in vitro.
Report a problemFND-0650426806
07AnimalAnimal study (in vivo)Efficacy outcome
In orchidectomized rats, intraventricular dermorphin appeared to increase prolactin only at 30 min.
In plain wordsIn rats with testes removed, dermorphin into a brain ventricle appeared to increase prolactin only at 30 min.
Peptide
Dermorphin
Outcome
IncreaseSerum prolactin at 30 min after orchidectomy
Study
ratn: not reported in source
orchidectomized rats
Outcome group
Pituitary hormones · Endocrine and hormones
Studied dose
0.25 micrograms/kg · intraventricularAs given in this study (rat).
Source sentences
Summary
In orchidectomized (3 weeks) rats, the intraventricular administration of dermorphin at the dose of 0.25 micrograms/kg appears effective in enhancing Prl levels only 30 min after treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of dermorphin, a new opioid peptide originally isolated from amphibian skin, on the release of prolactin (Prl) was studied in vivo and in vitro.
Report a problemFND-0650426807
08AnimalAnimal study (in vivo)Efficacy outcome
In orchidectomized rats, intraventricular dermorphin did not significantly change prolactin at 10 and 60 min.
In plain wordsIn rats with testes removed, dermorphin into a brain ventricle did not significantly change prolactin at 10 and 60 min.
Peptide
Dermorphin
Outcome
No significant changeSerum prolactin at 10 and 60 min after orchidectomy
Study
ratn: not reported in source
orchidectomized rats
Outcome group
Pituitary hormones · Endocrine and hormones
Studied dose
0.25 micrograms/kg · intraventricularAs given in this study (rat).
Source sentences
Summary
No statistically significant modifications are observed at 10 and 60 min with this dose.(ABSTRACT TRUNCATED AT 250 WORDS)
2 context sentences(design, population, supporting numbers)
Summary · context
In orchidectomized (3 weeks) rats, the intraventricular administration of dermorphin at the dose of 0.25 micrograms/kg appears effective in enhancing Prl levels only 30 min after treatment.
Summary · context
The effect of dermorphin, a new opioid peptide originally isolated from amphibian skin, on the release of prolactin (Prl) was studied in vivo and in vitro.
Report a problemFND-0650426808

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

PepBank is a research reference. Talk to a doctor before you use any peptide.