Stimulation of crop sac and pituitary lactotrophs after intraventricular administration of dermorphin in pigeons.

Rotiroti D, Germanà G, Nisticò G, Melchiorri P, Erspamer V

General and comparative endocrinology1 Oct 1984Cited by 5 (Europe PMC)

PMID6489737DOI10.1016/0016-6480(84)90057-1PepBankPUB-06489737

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In pigeons, a single dermorphin administration produced maximal crop sac stimulation with milk-like material and microscopic changes.
In plain wordsIn pigeons, a single dermorphin dose maximally stimulated the crop sac, with milk-like material and microscopic changes.
Peptide
Dermorphin
Outcome
IncreaseCrop sac stimulation after single administration
Study
Columba livian: not reported in source
pigeon crop sac and pituitary lactotrophs
Outcome group
Lactation and milk synthesis · Endocrine and hormones
Studied dose
1 microgram · third cerebral ventricle · single administrationAs given in this study (Columba livia).
Source sentences
Summary
A single administration of dermorphin into the third cerebral ventricle (1 microgram) and the same dose repeated for 3 consecutive days both produced maximal crop sac stimulation, as documented by the presence of milk-like material as well as by scanning and transmission electron microscopy of crop sac mucosa.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of dermorphin, a new potent opioid peptide, on structural and ultrastructural changes in the crop sac and in pituitary lactotrophs were assessed in pigeons (Columba livia).
Report a problemFND-0648973701
02AnimalAnimal study (in vivo)Efficacy outcome
In pigeons, repeated dermorphin administration produced maximal crop sac stimulation with milk-like material and microscopic changes.
In plain wordsIn pigeons, repeated dermorphin doses maximally stimulated the crop sac, with milk-like material and microscopic changes.
Peptide
Dermorphin
Outcome
IncreaseCrop sac stimulation after repeated administration
Study
Columba livian: not reported in source
pigeon crop sac and pituitary lactotrophs
Outcome group
Lactation and milk synthesis · Endocrine and hormones
Studied dose
1 microgram · third cerebral ventricle · 3 consecutive daysAs given in this study (Columba livia).
Source sentences
Summary
A single administration of dermorphin into the third cerebral ventricle (1 microgram) and the same dose repeated for 3 consecutive days both produced maximal crop sac stimulation, as documented by the presence of milk-like material as well as by scanning and transmission electron microscopy of crop sac mucosa.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of dermorphin, a new potent opioid peptide, on structural and ultrastructural changes in the crop sac and in pituitary lactotrophs were assessed in pigeons (Columba livia).
Report a problemFND-0648973702
03AnimalAnimal study (in vivo)Efficacy outcome
In pigeons, dermorphin stimulated the Golgi apparatus in pituitary lactotrophs.
In plain wordsIn pigeons, dermorphin stimulated the Golgi apparatus in prolactin-producing pituitary cells.
Peptide
Dermorphin
Outcome
IncreaseLactotroph Golgi apparatus stimulation
Study
Columba livian: not reported in source
pigeon crop sac and pituitary lactotrophs
Outcome group
Lactation and milk synthesis · Endocrine and hormones
Studied dose
1 microgram · third cerebral ventricleAs given in this study (Columba livia).
Source sentences
Summary
In addition, marked stimulatory effects were also observed in pituitary lactotrophs, as shown by stimulation of Golgi apparatus, enlargement of rough endoplasmic reticulum, increase in mitochondria size, and the presence of lysosomes and electron-opaque granules.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of dermorphin, a new potent opioid peptide, on structural and ultrastructural changes in the crop sac and in pituitary lactotrophs were assessed in pigeons (Columba livia).
Report a problemFND-0648973703
04AnimalAnimal study (in vivo)Efficacy outcome
In pigeons, dermorphin enlarged the rough endoplasmic reticulum in pituitary lactotrophs.
In plain wordsIn pigeons, dermorphin enlarged the rough endoplasmic reticulum in prolactin-producing pituitary cells.
Peptide
Dermorphin
Outcome
IncreaseLactotroph rough endoplasmic reticulum enlargement
Study
Columba livian: not reported in source
pigeon crop sac and pituitary lactotrophs
Outcome group
Lactation and milk synthesis · Endocrine and hormones
Studied dose
1 microgram · third cerebral ventricleAs given in this study (Columba livia).
Source sentences
Summary
In addition, marked stimulatory effects were also observed in pituitary lactotrophs, as shown by stimulation of Golgi apparatus, enlargement of rough endoplasmic reticulum, increase in mitochondria size, and the presence of lysosomes and electron-opaque granules.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of dermorphin, a new potent opioid peptide, on structural and ultrastructural changes in the crop sac and in pituitary lactotrophs were assessed in pigeons (Columba livia).
Report a problemFND-0648973704
05AnimalAnimal study (in vivo)Efficacy outcome
In pigeons, dermorphin increased mitochondrial size in pituitary lactotrophs.
In plain wordsIn pigeons, dermorphin increased mitochondrial size in prolactin-producing pituitary cells.
Peptide
Dermorphin
Outcome
IncreaseLactotroph mitochondrial size
Study
Columba livian: not reported in source
pigeon crop sac and pituitary lactotrophs
Outcome group
Lactation and milk synthesis · Endocrine and hormones
Studied dose
1 microgram · third cerebral ventricleAs given in this study (Columba livia).
Source sentences
Summary
In addition, marked stimulatory effects were also observed in pituitary lactotrophs, as shown by stimulation of Golgi apparatus, enlargement of rough endoplasmic reticulum, increase in mitochondria size, and the presence of lysosomes and electron-opaque granules.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of dermorphin, a new potent opioid peptide, on structural and ultrastructural changes in the crop sac and in pituitary lactotrophs were assessed in pigeons (Columba livia).
Report a problemFND-0648973705
06AnimalAnimal study (in vivo)Efficacy outcome
In pigeons, dermorphin-associated lactotroph stimulation included lysosomes and electron-opaque granules.
In plain wordsIn pigeons, stimulated prolactin-producing pituitary cells showed lysosomes and electron-opaque granules after dermorphin.
Peptide
Dermorphin
Outcome
Not applicableLactotroph lysosomes and electron-opaque granules
Study
Columba livian: not reported in source
pigeon crop sac and pituitary lactotrophs
Outcome group
Lactation and milk synthesis · Endocrine and hormones
Studied dose
1 microgram · third cerebral ventricleAs given in this study (Columba livia).
Source sentences
Summary
In addition, marked stimulatory effects were also observed in pituitary lactotrophs, as shown by stimulation of Golgi apparatus, enlargement of rough endoplasmic reticulum, increase in mitochondria size, and the presence of lysosomes and electron-opaque granules.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of dermorphin, a new potent opioid peptide, on structural and ultrastructural changes in the crop sac and in pituitary lactotrophs were assessed in pigeons (Columba livia).
Report a problemFND-0648973706

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

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