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Study · Ex vivo tissue · rat · 1984

6 results

Contrasting effects of neurohypophysial peptides on pyramidal and non-pyramidal neurones in the rat hippocampus.

Mühlethaler M, Charpak S, Dreifuss JJ

Brain research1 Aug 1984Cited by 77 (Europe PMC)

PMID6478205 (opens in a new tab)DOI10.1016/0006-8993(84)90921-1 (opens in a new tab)PepBankPUB-06478205
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueActivity measurement

    In rat hippocampal slices, oxytocin increased the firing rate of presumed non-pyramidal neurons in the CA1 area.

    In plain wordsIn rat hippocampal slices, oxytocin increased firing in presumed non-pyramidal neurons.

    Peptide
    Oxytocin
    Outcome
    IncreaseFiring rate of non-pyramidal neurons
    Study

    ratn: not reported in source

    hippocampal slices
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Oxytocin and vasopressin increased the rate of firing of a class of presumed non-pyramidal neurones located in the CA1 area of rat hippocampal slices.
    1 context sentence
    Title · context
    Contrasting effects of neurohypophysial peptides on pyramidal and non-pyramidal neurones in the rat hippocampus.
  2. 02LabEx vivo tissueActivity measurement

    In rat hippocampal slices, oxytocin's excitatory effect on non-pyramidal neurons persisted during synaptic uncoupling.

    In plain wordsIn rat hippocampal slices, oxytocin's excitatory effect on non-pyramidal neurons continued during synaptic uncoupling.

    Peptide
    Oxytocin
    Outcome
    IncreaseExcitatory effect on non-pyramidal neurons during synaptic uncoupling
    Study

    ratn: not reported in source

    hippocampal slices
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    This excitatory effect persisted in conditions of synaptic uncoupling.
    2 context sentences
    Summary · context
    Oxytocin and vasopressin increased the rate of firing of a class of presumed non-pyramidal neurones located in the CA1 area of rat hippocampal slices.
    Title · context
    Contrasting effects of neurohypophysial peptides on pyramidal and non-pyramidal neurones in the rat hippocampus.

Studies that did not test the peptide alone4

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 03LabNot a test of Oxytocin aloneEx vivo tissueActivity measurement

    In rat hippocampal slices, neurohypophysial peptides, including oxytocin, left pyramidal neurons unaffected.

    In plain wordsIn lab tests with rat hippocampal slices, neurohypophysial peptides including oxytocin left pyramidal neurons unchanged.

    Peptide
    Oxytocin
    Outcome
    No significant changeFiring rate of pyramidal neurons
    Study

    ratn: not reported in source

    hippocampal slices
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    In contrast, pyramidal neurones were either unaffected by neurohypophysial peptides or showed one or several of the following effects: a decrease in firing rate in cells which were spontaneously active
    1 context sentence
    Title · context
    Contrasting effects of neurohypophysial peptides on pyramidal and non-pyramidal neurones in the rat hippocampus.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 04LabNot a test of Oxytocin aloneEx vivo tissueActivity measurement

    In rat hippocampal slices, neurohypophysial peptides, including oxytocin, produced slight membrane hyperpolarization in pyramidal neurons.

    In plain wordsIn lab tests with rat hippocampal slices, neurohypophysial peptides including oxytocin slightly hyperpolarized pyramidal neurons.

    Peptide
    Oxytocin
    Outcome
    DecreaseMembrane potential of pyramidal neurons
    Study

    ratn: not reported in source

    hippocampal slices
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    a slight membrane hyperpolarization
    1 context sentence
    Title · context
    Contrasting effects of neurohypophysial peptides on pyramidal and non-pyramidal neurones in the rat hippocampus.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  3. 05LabNot a test of Oxytocin aloneEx vivo tissueActivity measurement

    In rat hippocampal slices, neurohypophysial peptides, including oxytocin, increased the rate of spontaneous inhibitory postsynaptic potentials in pyramidal neurons.

    In plain wordsIn lab tests with rat hippocampal slices, neurohypophysial peptides including oxytocin increased spontaneous inhibitory signals in pyramidal neurons.

    Peptide
    Oxytocin
    Outcome
    IncreaseSpontaneous inhibitory postsynaptic potential rate
    Study

    ratn: not reported in source

    hippocampal slices
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    an increase in the rate of occurrence of spontaneous inhibitory postsynaptic potentials
    1 context sentence
    Title · context
    Contrasting effects of neurohypophysial peptides on pyramidal and non-pyramidal neurones in the rat hippocampus.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  4. 06LabNot a test of Oxytocin aloneEx vivo tissueActivity measurement

    In rat hippocampal slices, neurohypophysial peptides, including oxytocin, decreased firing in spontaneously active pyramidal neurons.

    In plain wordsIn lab tests with rat hippocampal slices, neurohypophysial peptides including oxytocin lowered firing in spontaneously active pyramidal neurons.

    Peptide
    Oxytocin
    Outcome
    DecreaseFiring rate of spontaneously active pyramidal neurons
    Study

    ratn: not reported in source

    hippocampal slices
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    In contrast, pyramidal neurones were either unaffected by neurohypophysial peptides or showed one or several of the following effects: a decrease in firing rate in cells which were spontaneously active; a slight membrane hyperpolarization; and an increase in the rate of occurrence of spontaneous inh…
    1 context sentence
    Title · context
    Contrasting effects of neurohypophysial peptides on pyramidal and non-pyramidal neurones in the rat hippocampus.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:53 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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