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Study · Non-randomized trial · 1984

1 result

Dermorphin, a new opioid peptide, stimulates thyrotropin secretion in normal subjects.

Roti E, Degli Uberti E, Salvadori S, Bianconi M, Emanuele R, Rotola C, Trasforini G, Robuschi G, Tomatis R, Gnudi A

Journal of endocrinological investigation1 Jun 1984Cited by 6 (Europe PMC)

PMID6470436 (opens in a new tab)DOI10.1007/bf03348425 (opens in a new tab)PepBankPUB-06470436
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. 1 result from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In euthyroid subjects, dermorphin significantly increased serum TSH at 60, 90, and 120 min after infusion began.

    In plain wordsIn people with normal thyroid function, dermorphin increased thyroid-stimulating hormone after infusion.

    Peptide
    Dermorphin
    Outcome
    IncreaseSerum thyrotropin
    Study

    n: not reported in source

    Outcome group
    Thyroid function · Endocrine and hormones
    Studied dose
    5.5 micrograms/Kg/min · infusion · 30 minAs given in this study (human).

    Source sentences

    Summary
    DER infused at a rate of 5.5 micrograms/Kg/min for 30 min induced a significant increase in serum TSH concentration at 60, 90, and 120 min after the infusion was begun.
    1 context sentence
    Summary · context
    The effect of a recently described, potent opioid peptide, dermorphin (DER), on TSH secretion in euthyroid subjects has been studied.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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