Effect of vasoactive intestinal peptide on vagally mediated tracheal pouch relaxation.

Venugopalan CS, Said SI, Drazen JM

Respiration physiology1 May 1984Cited by 17 (Europe PMC)

PMID6463427DOI10.1016/0034-5687(84)90104-xPepBankPUB-06463427

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In guinea pig tracheal pouch, VIP produced a dose-dependent relaxation of the pouch.
In plain wordsIn guinea pigs, VIP relaxed the windpipe pouch, and a higher dose relaxed it more.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseTracheal pouch relaxation
Study
guinea pign: not reported in source
isolated tracheal pouch in vivo
Outcome group
Respiratory function · Respiratory
Studied dose
Dose not stated
Source sentences
Summary
VIP though less potent than isoproterenol produced a dose-dependent relaxation of the pouch.
1 context sentence(design, population, supporting numbers)
Summary · context
Vasoactive intestinal peptide (VIP) was studied as a possible neurotransmitter of nonadrenergic inhibition in guinea pig tracheas in vivo, by examining the effects of VIP and isoproterenol on pressure changes induced by nerve stimulation in an isolated, fluid filled, tracheal segment (tracheal pouch).
Report a problemFND-0646342701
02AnimalAnimal study (in vivo)Efficacy outcome
In guinea pig tracheal pouch, VIP was less potent than isoproterenol in relaxing the pouch.
In plain wordsIn guinea pigs, VIP relaxed the windpipe pouch less strongly than isoproterenol.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseRelaxation potency, VIP versus isoproterenol
Study
guinea pign: not reported in source
isolated tracheal pouch in vivo
Comparator
Isoproterenol
Outcome group
Respiratory function · Respiratory
Studied dose
Dose not stated
Source sentences
Summary
VIP though less potent than isoproterenol produced a dose-dependent relaxation of the pouch.
1 context sentence(design, population, supporting numbers)
Summary · context
Vasoactive intestinal peptide (VIP) was studied as a possible neurotransmitter of nonadrenergic inhibition in guinea pig tracheas in vivo, by examining the effects of VIP and isoproterenol on pressure changes induced by nerve stimulation in an isolated, fluid filled, tracheal segment (tracheal pouch).
Report a problemFND-0646342702
03AnimalAnimal study (in vivo)Efficacy outcome
VIP incubation produced relaxation of the histamine-constricted guinea pig tracheal pouch.
In plain wordsIn guinea pigs, VIP relaxed a windpipe pouch that had been constricted with histamine.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseRelaxation of histamine-constricted pouch
Study
guinea pign: not reported in source
isolated tracheal pouch in vivo
Outcome group
Respiratory function · Respiratory
Studied dose
Dose not stated
Source sentences
Summary
VIP incubation produced relaxation of the histamine-constricted pouch
1 context sentence(design, population, supporting numbers)
Summary · context
Vasoactive intestinal peptide (VIP) was studied as a possible neurotransmitter of nonadrenergic inhibition in guinea pig tracheas in vivo, by examining the effects of VIP and isoproterenol on pressure changes induced by nerve stimulation in an isolated, fluid filled, tracheal segment (tracheal pouch).
Report a problemFND-0646342703
04AnimalAnimal study (in vivo)Mechanism
After VIP incubation, the loss of pouch responsiveness was greater to vagal than to sympathetic stimulation (P less than 0.02).
In plain wordsIn guinea pigs, VIP reduced the windpipe response to vagal nerve stimulation more than to sympathetic nerve stimulation.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseLoss of responsiveness to vagal versus sympathetic stimulation after VIP
Study
guinea pign: not reported in source
isolated tracheal pouch in vivo
Comparator
Sympathetic stimulation
Outcome group
Respiratory function · Respiratory
Studied dose
Dose not stated
Source sentences
Summary
resulted in a greater loss of responsiveness to vagal than to sympathetic stimulation (P less than 0.02).
1 context sentence(design, population, supporting numbers)
Summary · context
Vasoactive intestinal peptide (VIP) was studied as a possible neurotransmitter of nonadrenergic inhibition in guinea pig tracheas in vivo, by examining the effects of VIP and isoproterenol on pressure changes induced by nerve stimulation in an isolated, fluid filled, tracheal segment (tracheal pouch).
Report a problemFND-0646342704
05AnimalAnimal study (in vivo)Mechanism
In sympathectomized guinea pigs with propranolol, VIP incubation still reduced vagal responsiveness, confirming that its effect on vagally induced pouch relaxation is non-adrenergic.
In plain wordsIn guinea pigs, VIP's effect on nerve-driven windpipe relaxation did not depend on adrenaline-type signals.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseNon-adrenergic nature of VIP effect on vagally induced relaxation
Study
guinea pign: not reported in source
isolated tracheal pouch in vivo
Outcome group
Respiratory function · Respiratory
Studied dose
Dose not stated
Source sentences
Summary
By demonstrating loss of vagal responsiveness after VIP in guinea pigs, sympathectomized by 6-hydroxydopamine combined with incubation of the pouch with propranolol to eliminate circulating beta adrenergic inhibition, the effects of VIP incubation on vagally induced pouch relaxation were confirmed t…
1 context sentence(design, population, supporting numbers)
Summary · context
Vasoactive intestinal peptide (VIP) was studied as a possible neurotransmitter of nonadrenergic inhibition in guinea pig tracheas in vivo, by examining the effects of VIP and isoproterenol on pressure changes induced by nerve stimulation in an isolated, fluid filled, tracheal segment (tracheal pouch).
Report a problemFND-0646342705

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

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