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Study · Ex vivo tissue · 1981

2 results

Human postthymic precursor cells in health and disease. IV. Abnormalities in immunoregulatory T cell circuits in mixed connective tissue disease.

Alarcón-Segovia D, Palacios R

Arthritis and rheumatism1 Dec 1981Cited by 13 (Europe PMC)

PMID6459784 (opens in a new tab)DOI10.1002/art.1780241206 (opens in a new tab)PepBankPUB-06459784
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueActivity measurement

    In cells from patients with MCTD, serum thymic factor did not correct defective generation of suppression.

    In plain wordsIn lab tests, FTS did not correct defective immune suppression in MCTD cells.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changeGeneration of suppression
    Study

    humann = 7

    T cells from patients with mixed connective tissue disease
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    These functional defects were not correctable with serum thymic factor
    2 context sentences
    Summary · context
    Despite this increase of precursor cells, decreased Tgamma cells and abrogation in the generation of suppression and of feedback inhibition were noted.
    Summary · context
    Tar cells were increased in 7 patients with mixed connective tissue disease (MCTD) compared to normal age/sex-matched controls.
  2. 02LabEx vivo tissueActivity measurement

    In cells from patients with MCTD, serum thymic factor did not correct defective feedback inhibition.

    In plain wordsIn lab tests, FTS did not correct defective feedback inhibition in MCTD cells.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changeFeedback inhibition
    Study

    humann = 7

    T cells from patients with mixed connective tissue disease
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    These functional defects were not correctable with serum thymic factor
    2 context sentences
    Summary · context
    Despite this increase of precursor cells, decreased Tgamma cells and abrogation in the generation of suppression and of feedback inhibition were noted.
    Summary · context
    Tar cells were increased in 7 patients with mixed connective tissue disease (MCTD) compared to normal age/sex-matched controls.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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