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Study · Ex vivo tissue · 1980

4 results

Maturational effects of thymic hormones on human helper and suppressor T cells: effects of FTS ('Facteur Thymique Sérique') and thymosin.

Kaufman DB

Clinical and experimental immunology1 Mar 1980Cited by 21 (Europe PMC)

PMID6445799 (opens in a new tab)PepBankPUB-06445799
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueActivity measurement

    In healthy donor lymphocytes, FTS could induce helper T cells, but responses were unpredictable.

    In plain wordsIn lab tests with healthy donor cells, FTS could induce helper T cells, but responses were unpredictable.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseHelper T-cell induction
    Study

    humann: not reported in source

    peripheral blood lymphocytes from healthy donors
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · 24 hrAs given in this study (human).

    Source sentences

    Summary
    It was found that both factots were capable of inducing both helper and suppressor T cells and that the response was unpredictable.
    2 context sentences
    Summary · context
    Human peripheral blood lymphocytes were isolated from healthy donors and pre-incubated with two thymic factors, FTS, a new synthetic polypeptide originally isolated and purified from serum, and thymosin Fraction V.
    Summary · context
    After 24 hr of pre-incubation, the cells were washed and added to an allogeneic MLR and assayed for their ability to induce a suppressor or helper response.
  2. 02LabEx vivo tissueActivity measurement

    In healthy donor lymphocytes, FTS could induce suppressor T cells, but responses were unpredictable.

    In plain wordsIn lab tests with healthy donor cells, FTS could induce suppressor T cells, but responses were unpredictable.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseSuppressor T-cell induction
    Study

    humann: not reported in source

    peripheral blood lymphocytes from healthy donors
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · 24 hrAs given in this study (human).

    Source sentences

    Summary
    It was found that both factots were capable of inducing both helper and suppressor T cells and that the response was unpredictable.
    2 context sentences
    Summary · context
    Human peripheral blood lymphocytes were isolated from healthy donors and pre-incubated with two thymic factors, FTS, a new synthetic polypeptide originally isolated and purified from serum, and thymosin Fraction V.
    Summary · context
    After 24 hr of pre-incubation, the cells were washed and added to an allogeneic MLR and assayed for their ability to induce a suppressor or helper response.
  3. 03LabEx vivo tissueActivity measurement

    After FTS pre-incubation of healthy donor lymphocytes, more than 50% of subjects showed a helper effect.

    In plain wordsIn lab tests, cells from more than 50% of healthy donors showed a helper effect after FTS exposure.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    Not applicableSubjects with a helper effect
    Study

    humann: not reported in source

    peripheral blood lymphocytes from healthy donors
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · 24 hrAs given in this study (human).

    Measurements

    Subjects with helper effect
    > 50%
    FTS pre-incubation

    Source sentences

    Summary
    In both instances, more than 50% of the subjects studied responded with a helper effect.
    3 context sentences
    Summary · context
    It was found that both factots were capable of inducing both helper and suppressor T cells and that the response was unpredictable.
    Summary · context
    Human peripheral blood lymphocytes were isolated from healthy donors and pre-incubated with two thymic factors, FTS, a new synthetic polypeptide originally isolated and purified from serum, and thymosin Fraction V.
    Summary · context
    After 24 hr of pre-incubation, the cells were washed and added to an allogeneic MLR and assayed for their ability to induce a suppressor or helper response.

Studies that did not test the peptide alone1

In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymulin (serum thymic factor).

  1. 04LabNot a test of Thymulin (serum thymic factor) aloneEx vivo tissueActivity measurement

    In healthy donor lymphocytes, adding Con A augmented the effects induced by the thymic factors, including FTS.

    In plain wordsIn lab tests with healthy donor cells, Con A increased the effects of thymic factors, including FTS.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseCon A augmentation of T-cell effects
    Study

    humann: not reported in source

    peripheral blood lymphocytes from healthy donors
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    The addition of Con A augmented these effects.
    3 context sentences
    Summary · context
    It was found that both factots were capable of inducing both helper and suppressor T cells and that the response was unpredictable.
    Summary · context
    Human peripheral blood lymphocytes were isolated from healthy donors and pre-incubated with two thymic factors, FTS, a new synthetic polypeptide originally isolated and purified from serum, and thymosin Fraction V.
    Summary · context
    After 24 hr of pre-incubation, the cells were washed and added to an allogeneic MLR and assayed for their ability to induce a suppressor or helper response.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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