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Study · In vitro (cells) · 1984

2 results

Inhibition of the estradiol-induced growth of cultured human breast cancer cells by the anti-estrogens tamoxifen, desmethyl-tamoxifen, 4-hydroxy-tamoxifen and enclomiphene.

Marth C, Daxenbichler G, Buehring GC, Hofstädter F, Dapunt O

Biochemical pharmacology1 Dec 1984Cited by 16 (Europe PMC)

PMID6439216 (opens in a new tab)DOI10.1016/0006-2952(84)90007-8 (opens in a new tab)PepBankPUB-06439216
Publisher pagePubMedAsk about this study
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Summary

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Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In cultured breast cancer cells, enclomiphene markedly inhibited growth only when estrogen stimulated the cells.

    In plain wordsIn cells, enclomiphene inhibited breast cancer growth only when estrogen stimulated growth.

    Peptide
    Enclomiphene
    Outcome
    DecreaseEstrogen-stimulated cell growth
    Study

    humann: not reported in source

    734 B and ZR 75.1 breast cancer cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Only in cells which were stimulated by estrogens did these anti-estrogens markedly inhibit growth.
    1 context sentence
    Summary · context
    The growth effects of tamoxifen (T), desmethyl-tamoxifen (dMeT), 4-hydroxy-tamoxifen (OHT) and enclomiphene (Clo) on cultured human breast cancer cell lines have been related to published binding affinities for the estrogen receptor.
  2. 02LabIn vitro (cells)Efficacy outcome

    In both breast cancer cell lines, enclomiphene was less potent than 4-hydroxy-tamoxifen and approximately as potent as tamoxifen and desmethyl-tamoxifen.

    In plain wordsIn cells, enclomiphene inhibited growth less strongly than 4-hydroxy-tamoxifen and approximately as strongly as tamoxifen and desmethyl-tamoxifen.

    Peptide
    Enclomiphene
    Outcome
    MixedRelative antiproliferative potency
    Study

    humann: not reported in source

    734 B and ZR 75.1 breast cancer cells
    Comparator
    4-hydroxy-tamoxifen, tamoxifen and desmethyl-tamoxifen
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In both estrogen sensitive cell lines tested, 734 B and ZR 75.1, the anti-estrogen activity showed the identical rank: OHT much greater than Clo approximately equal to T = dMeT; this anti-proliferative potency agrees with reported affinities of these compounds for the estrogen receptor.
    1 context sentence
    Summary · context
    The growth effects of tamoxifen (T), desmethyl-tamoxifen (dMeT), 4-hydroxy-tamoxifen (OHT) and enclomiphene (Clo) on cultured human breast cancer cell lines have been related to published binding affinities for the estrogen receptor.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

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