In guinea pig lung fragments, serum thymic factor did not alter prostaglandin release relative to basal release.
In plain wordsIn lab tests, serum thymic factor did not change prostaglandin release from guinea pig lung tissue compared with basal release.
- Outcome
- No significant changeProstaglandin release
- Study
guinea pign: not reported in source
normal parenchymal lung fragments- Comparator
- Basal spontaneous release
- Outcome group
- Inflammation markers · Respiratory
- Studied dose
- Dose not stated · 30 minAs given in this study (guinea pig).
Source sentences
No alteration in PG levels (enhancement or suppression) from basal (spontaneous) release was found.
2 context sentences(design, population, supporting numbers)
These findings suggest that during a 30-min incubation, all four polypeptide immunomodulators were ineffective in eliciting an immediate response in the arachidonic acid cascade via the cyclooxygenase pathway.
Several concentrations of thymosin fraction 5, serum thymic factor, tuftsin or thymopentin, as well as histamine or A23187 (as positive controls) were exogenously applied to parenchymal lung fragments in vitro, and supernatants analyzed for PG content by radioimmunoassay.