Gap junction modulation in rat uterus. II. Effects of antiestrogens on myometrial and serosal cells.

Burghardt RC, Mitchell PA, Kurten R

Biology of reproduction1 Feb 1984Cited by 3 (Europe PMC)

PMID6421335DOI10.1095/biolreprod30.1.249PepBankPUB-06421335

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In hypophysectomized rats, enclomiphene promoted uterine luminal epithelial hypertrophy.
In plain wordsIn rats, enclomiphene increased the size of uterine lining cells.
Peptide
Enclomiphene
Outcome
IncreaseUterine epithelial hypertrophy
Study
ratn: not reported in source
Hypophysectomized rats
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Studied dose
500 micrograms per injection · Five daily injectionsAs given in this study (rat).
Source sentences
Summary
Five daily injections of enclomiphene, zuclomiphene, tamoxifen, nafoxidine, CI 628 or CI 680 (500 micrograms per injection) promote uterine luminal epithelial cell hypertrophy characteristic of exogenous estrogen administration.
1 context sentence(design, population, supporting numbers)
Summary · context
The ability of several triphenylethylene antiestrogens to affect the modulation of gap junctions in rat uterine myometrial and serosal cells was examined in animals 60 days following hypophysectomy.
Report a problemFND-0642133501
02AnimalAnimal study (in vivo)Efficacy outcome
In hypophysectomized rats, enclomiphene failed to induce myometrial gap junctions.
In plain wordsIn rats, enclomiphene did not induce gap junctions in uterine muscle cells.
Peptide
Enclomiphene
Outcome
No significant changeMyometrial gap junction induction
Study
ratn: not reported in source
Hypophysectomized rats
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Studied dose
500 micrograms per injection · Five daily injectionsAs given in this study (rat).
Source sentences
Summary
These same compounds, however, fail to induce myometrial cell or increase the number of serosal cell gap junctions, respectively, which is also characteristic of exogenous estrogen treatment.
2 context sentences(design, population, supporting numbers)
Summary · context
Five daily injections of enclomiphene, zuclomiphene, tamoxifen, nafoxidine, CI 628 or CI 680 (500 micrograms per injection) promote uterine luminal epithelial cell hypertrophy characteristic of exogenous estrogen administration.
Summary · context
The ability of several triphenylethylene antiestrogens to affect the modulation of gap junctions in rat uterine myometrial and serosal cells was examined in animals 60 days following hypophysectomy.
Report a problemFND-0642133502
03AnimalAnimal study (in vivo)Efficacy outcome
In hypophysectomized rats, enclomiphene failed to increase serosal cell gap junction numbers.
In plain wordsIn rats, enclomiphene did not increase gap junction numbers in uterine serosal cells.
Peptide
Enclomiphene
Outcome
No significant changeSerosal gap junction number
Study
ratn: not reported in source
Hypophysectomized rats
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Studied dose
500 micrograms per injection · Five daily injectionsAs given in this study (rat).
Source sentences
Summary
These same compounds, however, fail to induce myometrial cell or increase the number of serosal cell gap junctions, respectively, which is also characteristic of exogenous estrogen treatment.
2 context sentences(design, population, supporting numbers)
Summary · context
Five daily injections of enclomiphene, zuclomiphene, tamoxifen, nafoxidine, CI 628 or CI 680 (500 micrograms per injection) promote uterine luminal epithelial cell hypertrophy characteristic of exogenous estrogen administration.
Summary · context
The ability of several triphenylethylene antiestrogens to affect the modulation of gap junctions in rat uterine myometrial and serosal cells was examined in animals 60 days following hypophysectomy.
Report a problemFND-0642133503
04AnimalAnimal study (in vivo)Efficacy outcome
In rats, antiestrogen pretreatment including enclomiphene blocked estradiol-induced myometrial gap junction formation.
In plain wordsIn rats, pretreatment with enclomiphene blocked estradiol-induced gap junction formation in uterine muscle cells.
Peptide
Enclomiphene
Outcome
DecreaseEstradiol-induced myometrial gap junction formation
Study
ratn: not reported in source
Hypophysectomized rats
Comparator
Estradiol benzoate alone
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Studied dose
250 micrograms · 5 daysAs given in this study (rat).
Source sentences
Summary
Pretreatment of animals with antiestrogens blocks the ability of estradiol benzoate (E2 B) to induce gap junction formation in myometrial cells when followed by combined injections of E2 B and antiestrogens (both 250 micrograms) administered daily for 5 days.
2 context sentences(design, population, supporting numbers)
Summary · context
Five daily injections of enclomiphene, zuclomiphene, tamoxifen, nafoxidine, CI 628 or CI 680 (500 micrograms per injection) promote uterine luminal epithelial cell hypertrophy characteristic of exogenous estrogen administration.
Summary · context
The ability of several triphenylethylene antiestrogens to affect the modulation of gap junctions in rat uterine myometrial and serosal cells was examined in animals 60 days following hypophysectomy.
Report a problemFND-0642133504
05AnimalAnimal study (in vivo)Efficacy outcome
In rats, antiestrogen pretreatment including enclomiphene weakly antagonized estradiol modulation of serosal gap junction membrane.
In plain wordsIn rats, enclomiphene pretreatment weakly opposed estradiol effects on serosal cell gap junctions.
Peptide
Enclomiphene
Outcome
DecreaseEstradiol modulation of serosal gap junctions
Study
ratn: not reported in source
Hypophysectomized rats
Comparator
Estradiol benzoate alone
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
These same antiestrogen pretreatments only weakly antagonized the ability of E2 B to modulate serosal cell gap junction membrane.
3 context sentences(design, population, supporting numbers)
Summary · context
Pretreatment of animals with antiestrogens blocks the ability of estradiol benzoate (E2 B) to induce gap junction formation in myometrial cells when followed by combined injections of E2 B and antiestrogens (both 250 micrograms) administered daily for 5 days.
Summary · context
Five daily injections of enclomiphene, zuclomiphene, tamoxifen, nafoxidine, CI 628 or CI 680 (500 micrograms per injection) promote uterine luminal epithelial cell hypertrophy characteristic of exogenous estrogen administration.
Summary · context
The ability of several triphenylethylene antiestrogens to affect the modulation of gap junctions in rat uterine myometrial and serosal cells was examined in animals 60 days following hypophysectomy.
Report a problemFND-0642133505

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

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