Skip to content

Study · Animal study (in vivo) · rat · 1983

12 results

Central autonomic effects of dermorphin in conscious rats.

Feuerstein G, Faden AI

The Journal of pharmacology and experimental therapeutics1 Jul 1983Cited by 17 (Europe PMC)

PMID6408244 (opens in a new tab)DOI10.1016/s0022-3565(25)21399-4 (opens in a new tab)PepBankPUB-06408244
Publisher pagePubMedAsk about this study
Jump to 12 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

12 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In conscious rats, dermorphin at the lower doses increased systolic blood pressure.

    In plain wordsIn rats, lower dermorphin doses increased systolic blood pressure.

    Peptide
    Dermorphin
    Outcome
    IncreaseSystolic blood pressure
    Study

    ratn: not reported in source

    conscious rats
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    0.1 or 1 nM · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    Intracerebroventricular administration (0.1 or 1 nM) of dermorphin increased the systolic and diastolic blood pressure whereas a high dose (50 nM) decreased blood pressure.
    1 context sentence
    Summary · context
    Central cardiovascular and respiratory effects of dermorphin were studied in conscious rats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In conscious rats, dermorphin at the lower doses increased diastolic blood pressure.

    In plain wordsIn rats, lower dermorphin doses increased diastolic blood pressure.

    Peptide
    Dermorphin
    Outcome
    IncreaseDiastolic blood pressure
    Study

    ratn: not reported in source

    conscious rats
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    0.1 or 1 nM · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    Intracerebroventricular administration (0.1 or 1 nM) of dermorphin increased the systolic and diastolic blood pressure whereas a high dose (50 nM) decreased blood pressure.
    1 context sentence
    Summary · context
    Central cardiovascular and respiratory effects of dermorphin were studied in conscious rats.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In conscious rats, high-dose dermorphin decreased blood pressure.

    In plain wordsIn rats, high-dose dermorphin decreased blood pressure.

    Peptide
    Dermorphin
    Outcome
    DecreaseBlood pressure
    Study

    ratn: not reported in source

    conscious rats
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    50 nM · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    Intracerebroventricular administration (0.1 or 1 nM) of dermorphin increased the systolic and diastolic blood pressure whereas a high dose (50 nM) decreased blood pressure.
    1 context sentence
    Summary · context
    Central cardiovascular and respiratory effects of dermorphin were studied in conscious rats.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In conscious rats, dermorphin increased respiratory rate at the lower reported dose.

    In plain wordsIn rats, the lower dermorphin dose increased breathing rate.

    Peptide
    Dermorphin
    Outcome
    IncreaseRespiratory rate
    Study

    ratn: not reported in source

    conscious rats
    Outcome group
    Respiratory function · Respiratory
    Studied dose
    1 nM · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    Dermorphin at 1 nM increased respiratory rate but caused hypoxia, acidosis and hypercapnia; at 50 nM, respiratory rate was suppressed.
    1 context sentence
    Summary · context
    Central cardiovascular and respiratory effects of dermorphin were studied in conscious rats.
  5. 05AnimalAnimal study (in vivo)Safety outcome

    In conscious rats, dermorphin caused hypoxia.

    In plain wordsIn rats, dermorphin caused low oxygen levels.

    Peptide
    Dermorphin
    Outcome
    IncreaseHypoxia
    Study

    ratn: not reported in source

    conscious rats
    Outcome group
    Adverse events · Respiratory
    Studied dose
    1 nM · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    Dermorphin at 1 nM increased respiratory rate but caused hypoxia, acidosis and hypercapnia; at 50 nM, respiratory rate was suppressed.
    1 context sentence
    Summary · context
    Central cardiovascular and respiratory effects of dermorphin were studied in conscious rats.
  6. 06AnimalAnimal study (in vivo)Safety outcome

    In conscious rats, dermorphin caused acidosis.

    In plain wordsIn rats, dermorphin caused acidosis.

    Peptide
    Dermorphin
    Outcome
    IncreaseAcidosis
    Study

    ratn: not reported in source

    conscious rats
    Outcome group
    Adverse events · Whole body
    Studied dose
    1 nM · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    Dermorphin at 1 nM increased respiratory rate but caused hypoxia, acidosis and hypercapnia; at 50 nM, respiratory rate was suppressed.
    1 context sentence
    Summary · context
    Central cardiovascular and respiratory effects of dermorphin were studied in conscious rats.
  7. 07AnimalAnimal study (in vivo)Safety outcome

    In conscious rats, dermorphin caused hypercapnia.

    In plain wordsIn rats, dermorphin caused high carbon dioxide levels.

    Peptide
    Dermorphin
    Outcome
    IncreaseHypercapnia
    Study

    ratn: not reported in source

    conscious rats
    Outcome group
    Adverse events · Respiratory
    Studied dose
    1 nM · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    Dermorphin at 1 nM increased respiratory rate but caused hypoxia, acidosis and hypercapnia; at 50 nM, respiratory rate was suppressed.
    1 context sentence
    Summary · context
    Central cardiovascular and respiratory effects of dermorphin were studied in conscious rats.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In conscious rats, high-dose dermorphin suppressed respiratory rate.

    In plain wordsIn rats, high-dose dermorphin reduced breathing rate.

    Peptide
    Dermorphin
    Outcome
    DecreaseRespiratory rate
    Study

    ratn: not reported in source

    conscious rats
    Outcome group
    Respiratory function · Respiratory
    Studied dose
    50 nM · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    Dermorphin at 1 nM increased respiratory rate but caused hypoxia, acidosis and hypercapnia; at 50 nM, respiratory rate was suppressed.
    1 context sentence
    Summary · context
    Central cardiovascular and respiratory effects of dermorphin were studied in conscious rats.
  9. 09AnimalAnimal study (in vivo)Safety outcome

    In conscious rats, both reported dermorphin doses produced catalepsy.

    In plain wordsIn rats, both dermorphin doses caused catalepsy.

    Peptide
    Dermorphin
    Outcome
    IncreaseCatalepsy
    Study

    ratn: not reported in source

    conscious rats
    Outcome group
    Adverse events · Nervous system and cognition
    Studied dose
    1 or 50 nM · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    Both of these doses produced catalepsy.
    2 context sentences
    Summary · context
    Dermorphin at 1 nM increased respiratory rate but caused hypoxia, acidosis and hypercapnia; at 50 nM, respiratory rate was suppressed.
    Summary · context
    Central cardiovascular and respiratory effects of dermorphin were studied in conscious rats.
  10. 10AnimalAnimal study (in vivo)Mechanism

    In conscious rats, the dermorphin pressor period involved high circulating epinephrine levels.

    In plain wordsIn rats, blood epinephrine levels were high during the dermorphin blood pressure response.

    Peptide
    Dermorphin
    Outcome
    IncreaseCirculating epinephrine
    Study

    ratn: not reported in source

    conscious rats
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    1 nM · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    Stimulation of the sympathoadrenomedullary axis at the pressor period elicited by 1 nM dermorphin was evident by high circulating levels of epinephrine and norepinephrine.
    1 context sentence
    Summary · context
    Central cardiovascular and respiratory effects of dermorphin were studied in conscious rats.
  11. 11AnimalAnimal study (in vivo)Mechanism

    In conscious rats, the dermorphin pressor period involved high circulating norepinephrine levels.

    In plain wordsIn rats, blood norepinephrine levels were high during the dermorphin blood pressure response.

    Peptide
    Dermorphin
    Outcome
    IncreaseCirculating norepinephrine
    Study

    ratn: not reported in source

    conscious rats
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    1 nM · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    Stimulation of the sympathoadrenomedullary axis at the pressor period elicited by 1 nM dermorphin was evident by high circulating levels of epinephrine and norepinephrine.
    1 context sentence
    Summary · context
    Central cardiovascular and respiratory effects of dermorphin were studied in conscious rats.
  12. 12AnimalAnimal study (in vivo)Safety outcome

    In conscious rats, dermorphin induced severe bradycardia.

    In plain wordsIn rats, dermorphin caused a severely slow heart rate.

    Peptide
    Dermorphin
    Outcome
    DecreaseHeart rate
    Study

    ratn: not reported in source

    conscious rats
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    the severe bradycardia induced by dermorphin
    1 context sentence
    Summary · context
    Central cardiovascular and respiratory effects of dermorphin were studied in conscious rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.