The estrogenic effects of clomiphene during the neonatal period in the rat.

Clark JH, Guthrie SC

Journal of steroid biochemistry1 May 1983Cited by 8 (Europe PMC)

PMID6406767DOI10.1016/0022-4731(83)90124-3PepBankPUB-06406767

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

1 result from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In neonatal rats, enclomiphene accelerated vaginal opening as did all drug treatments.
In plain wordsIn rats, enclomiphene accelerated vaginal opening, as did the other drugs.
Peptide
Enclomiphene
Outcome
DecreaseTime of vaginal opening
Study
ratn: not reported in source
Neonatal rats
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · subcutaneous · Days 1,3, and 5 of lifeAs given in this study (rat).
Source sentences
Summary
The time of vaginal opening was greatly accelerated in all drug treated groups with the earliest day of opening occurring on day 7.
1 context sentence(design, population, supporting numbers)
Summary · context
Rats were injected s.c. with clomiphene (CL), zuclomiphene (ZUC) or enclomiphene (ENC) on days 1,3, and 5 of life and the stimulation of the reproductive tract and estrogen receptor binding was observed.
Report a problemFND-0640676702

Studies that did not test the peptide alone5

In this study, Enclomiphene was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Enclomiphene.

02AnimalNot a test of Enclomiphene aloneAnimal study (in vivo)Efficacy outcome
In neonatal rats, uterine epithelial hypertrophy appeared in all groups, including the enclomiphene group, by day 10.
In plain wordsIn rats, uterine lining cell enlargement occurred in all groups, including the enclomiphene group.
Peptide
Enclomiphene
Outcome
Direction not reportedUterine epithelial hypertrophy
Study
ratn: not reported in source
Neonatal rats
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Uterine epithelial hypertrophy was present in all groups by day 10 and hyperplasia was present in the animals treated with ZUC and CL.
1 context sentence(design, population, supporting numbers)
Summary · context
Rats were injected s.c. with clomiphene (CL), zuclomiphene (ZUC) or enclomiphene (ENC) on days 1,3, and 5 of life and the stimulation of the reproductive tract and estrogen receptor binding was observed.
In this study, Enclomiphene was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Enclomiphene.
Report a problemFND-0640676701
03AnimalNot a test of Enclomiphene aloneAnimal study (in vivo)Safety outcome
In the neonatal rat drug study including enclomiphene, ovarian hemorrhage occurred between days 12-14 and persisted through day 25.
In plain wordsIn rats, the study including enclomiphene reported ovarian bleeding, without identifying the affected treatment group.
Peptide
Enclomiphene
Outcome
Direction not reportedOvarian hemorrhage
Study
ratn: not reported in source
Neonatal rats
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Ovarian hemorrhage and blood in the periovarian sac occurred between days 12-14 and continued to be present through day 25.
1 context sentence(design, population, supporting numbers)
Summary · context
Rats were injected s.c. with clomiphene (CL), zuclomiphene (ZUC) or enclomiphene (ENC) on days 1,3, and 5 of life and the stimulation of the reproductive tract and estrogen receptor binding was observed.
In this study, Enclomiphene was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Enclomiphene.
Report a problemFND-0640676703
04AnimalNot a test of Enclomiphene aloneAnimal study (in vivo)Safety outcome
In the neonatal rat drug study including enclomiphene, blood in the periovarian sac occurred between days 12-14 through day 25.
In plain wordsIn rats, the study including enclomiphene reported blood around the ovaries, without identifying the affected treatment group.
Peptide
Enclomiphene
Outcome
Direction not reportedBlood in periovarian sac
Study
ratn: not reported in source
Neonatal rats
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Ovarian hemorrhage and blood in the periovarian sac occurred between days 12-14 and continued to be present through day 25.
1 context sentence(design, population, supporting numbers)
Summary · context
Rats were injected s.c. with clomiphene (CL), zuclomiphene (ZUC) or enclomiphene (ENC) on days 1,3, and 5 of life and the stimulation of the reproductive tract and estrogen receptor binding was observed.
In this study, Enclomiphene was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Enclomiphene.
Report a problemFND-0640676704
05AnimalNot a test of Enclomiphene aloneAnimal study (in vivo)Mechanism
In neonatal rats, drug treatment including enclomiphene increased estrogen receptor accumulation in the uterine nuclear fraction.
In plain wordsIn rats, drug treatment including enclomiphene increased estrogen receptors in uterine cell nuclei.
Peptide
Enclomiphene
Outcome
IncreaseNuclear uterine estrogen receptor
Study
ratn: not reported in source
Neonatal rats
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Drug treatment caused the estrogen receptor to accumulate in the nuclear fraction of the uterus and to be depleted from the cytosol fraction.
1 context sentence(design, population, supporting numbers)
Summary · context
Rats were injected s.c. with clomiphene (CL), zuclomiphene (ZUC) or enclomiphene (ENC) on days 1,3, and 5 of life and the stimulation of the reproductive tract and estrogen receptor binding was observed.
In this study, Enclomiphene was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Enclomiphene.
Report a problemFND-0640676705
06AnimalNot a test of Enclomiphene aloneAnimal study (in vivo)Mechanism
In neonatal rats, drug treatment including enclomiphene depleted estrogen receptors from the uterine cytosol fraction.
In plain wordsIn rats, drug treatment including enclomiphene reduced estrogen receptors in the uterine cytosol.
Peptide
Enclomiphene
Outcome
DecreaseCytosolic uterine estrogen receptor
Study
ratn: not reported in source
Neonatal rats
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Drug treatment caused the estrogen receptor to accumulate in the nuclear fraction of the uterus and to be depleted from the cytosol fraction.
1 context sentence(design, population, supporting numbers)
Summary · context
Rats were injected s.c. with clomiphene (CL), zuclomiphene (ZUC) or enclomiphene (ENC) on days 1,3, and 5 of life and the stimulation of the reproductive tract and estrogen receptor binding was observed.
In this study, Enclomiphene was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Enclomiphene.
Report a problemFND-0640676706

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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