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Study · Animal study (in vivo) · mouse · 1983

8 results

Protective activity of thymosin against opportunistic infections in animal models.

Ishitsuka H, Umeda Y, Nakamura J, Yagi Y

Cancer immunology, immunotherapy : CII1 Jan 1983Cited by 25 (Europe PMC)

PMID6404549 (opens in a new tab)PMCIDPMC11039275 (opens in a new tab)DOI10.1007/bf00205352 (opens in a new tab)PepBankPUB-06404549
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In 5-FU-immunosuppressed mice, thymosin alpha‑1 given during 5-FU treatment protected against lethal infection with Candida albicans.

    In plain wordsIn immunosuppressed mice, thymosin alpha‑1 protected against deadly Candida infection.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseProtection against lethal Candida albicans infection
    Study

    mousen: not reported in source

    Mice immunosuppressed by 5-FU
    Outcome group
    Infection and antimicrobial activity · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In these models, thymosin alpha 1 was found to protect mice against lethal infections with Candida albicans, Listeria monocytogenes, Pseudomonas aeruginosa, and Serratia marcescens when it was administered during 5-FU treatment prior to the infections.
    1 context sentence
    Summary · context
    Animal models for opportunistic infections were developed by using mice immunosuppressed by 5-FU.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In 5-FU-immunosuppressed mice, thymosin alpha‑1 given during 5-FU treatment protected against lethal infection with Listeria monocytogenes.

    In plain wordsIn immunosuppressed mice, thymosin alpha‑1 protected against deadly Listeria infection.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseProtection against lethal Listeria monocytogenes infection
    Study

    mousen: not reported in source

    Mice immunosuppressed by 5-FU
    Outcome group
    Infection and antimicrobial activity · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In these models, thymosin alpha 1 was found to protect mice against lethal infections with Candida albicans, Listeria monocytogenes, Pseudomonas aeruginosa, and Serratia marcescens when it was administered during 5-FU treatment prior to the infections.
    1 context sentence
    Summary · context
    Animal models for opportunistic infections were developed by using mice immunosuppressed by 5-FU.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In 5-FU-immunosuppressed mice, thymosin alpha‑1 given during 5-FU treatment protected against lethal infection with Pseudomonas aeruginosa.

    In plain wordsIn immunosuppressed mice, thymosin alpha‑1 protected against deadly Pseudomonas infection.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseProtection against lethal Pseudomonas aeruginosa infection
    Study

    mousen: not reported in source

    Mice immunosuppressed by 5-FU
    Outcome group
    Infection and antimicrobial activity · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In these models, thymosin alpha 1 was found to protect mice against lethal infections with Candida albicans, Listeria monocytogenes, Pseudomonas aeruginosa, and Serratia marcescens when it was administered during 5-FU treatment prior to the infections.
    1 context sentence
    Summary · context
    Animal models for opportunistic infections were developed by using mice immunosuppressed by 5-FU.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In 5-FU-immunosuppressed mice, thymosin alpha‑1 given during 5-FU treatment protected against lethal infection with Serratia marcescens.

    In plain wordsIn immunosuppressed mice, thymosin alpha‑1 protected against deadly Serratia infection.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseProtection against lethal Serratia marcescens infection
    Study

    mousen: not reported in source

    Mice immunosuppressed by 5-FU
    Outcome group
    Infection and antimicrobial activity · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In these models, thymosin alpha 1 was found to protect mice against lethal infections with Candida albicans, Listeria monocytogenes, Pseudomonas aeruginosa, and Serratia marcescens when it was administered during 5-FU treatment prior to the infections.
    1 context sentence
    Summary · context
    Animal models for opportunistic infections were developed by using mice immunosuppressed by 5-FU.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    Thymosin alpha‑1 was effective in some infections at 0.4-400 micrograms/kg/day intraperitoneally, about 1/100 of the dose required for thymosin fraction 5.

    In plain wordsIn mice, thymosin alpha‑1 worked against some infections at doses about 100 times lower than crude thymosin fraction 5.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableEffective dose range in some infections
    Study

    mousen: not reported in source

    Mice immunosuppressed by 5-FU
    Outcome group
    Infection and antimicrobial activity · Infection
    Studied dose
    0.4-400 micrograms/kg/day · intraperitonealAs given in this study (mouse).

    Measurements

    Effective dose
    0.4 to 400 micrograms/kg/day
    some infections

    Source sentences

    Summary
    Thymosin alpha 1 was effective in some infections at 0.4-400 micrograms/kg/day IP, about 1/100 of the dose required for thymosin fraction 5.
    1 context sentence
    Summary · context
    Animal models for opportunistic infections were developed by using mice immunosuppressed by 5-FU.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    Counts of viable bacteria in the liver confirmed thymosin alpha‑1 activity against L. monocytogenes and Ps. aeruginosa infection in mice.

    In plain wordsIn immunosuppressed mice, thymosin alpha‑1 lowered the number of live Listeria and Pseudomonas bacteria in the liver.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseViable bacteria in liver after L. monocytogenes or Ps. aeruginosa infection
    Study

    mousen: not reported in source

    Mice immunosuppressed by 5-FU
    Outcome group
    Infection and antimicrobial activity · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Activity was also demonstrated against L-monocytogenes and Ps. aeruginosa by counting the viable bacteria in the liver after infection.
    1 context sentence
    Summary · context
    Animal models for opportunistic infections were developed by using mice immunosuppressed by 5-FU.
  7. 07AnimalAnimal study (in vivo)Mechanism

    Protection against Candida was abrogated by anti-thymocyte serum and/or carrageenan, which suggests that thymosin alpha‑1 maintains macrophage function by reducing T-cell damage from 5-FU.

    In plain wordsIn mice, blocking T cells or macrophages removed the protection thymosin alpha‑1 gave against Candida.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableRole of T cells and macrophages in protection against Candida
    Study

    mousen: not reported in source

    Mice immunosuppressed by 5-FU
    Outcome group
    Infection and antimicrobial activity · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The protective activity against Candida, elimination of which macrophages were essential, was abrogated by anti-thymocyte serum and/or carrageenan, indicating that thymosin alpha 1 serves to maintain the functions of macrophages by reducing the damage to T cells by 5-FU.
    1 context sentence
    Summary · context
    Animal models for opportunistic infections were developed by using mice immunosuppressed by 5-FU.
  8. 08AnimalAnimal study (in vivo)Mechanism

    The activity of thymosin alpha‑1 against Pseudomonas infection was not affected by anti-thymocyte serum or carrageenan.

    In plain wordsIn mice, blocking T cells or macrophages did not remove the protection thymosin alpha‑1 gave against Pseudomonas.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeRole of T cells and macrophages in protection against Pseudomonas
    Study

    mousen: not reported in source

    Mice immunosuppressed by 5-FU
    Outcome group
    Infection and antimicrobial activity · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    On the other hand, the activity against Pseudomonas infection was not affected by anti-thymocyte serum or carrageenan.
    1 context sentence
    Summary · context
    Animal models for opportunistic infections were developed by using mice immunosuppressed by 5-FU.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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