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Study · In vitro (cells) · sheep · 1983

4 results

Estrogenic and antiestrogenic effects of enclomiphene and zuclomiphene on gonadotropin secretion by ovine pituitary cells in culture.

Huang ES, Miller WL

Endocrinology1 Feb 1983Cited by 18 (Europe PMC)

PMID6401242 (opens in a new tab)DOI10.1210/endo-112-2-442 (opens in a new tab)PepBankPUB-06401242
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In ovine pituitary cultures, enclomiphene blocked estradiol augmentation of the LH response to LHRH.

    In plain wordsIn cells from sheep, enclomiphene blocked the estradiol-induced increase in the LH response to LHRH.

    Peptide
    Enclomiphene
    Outcome
    DecreaseEstradiol augmentation of LH response to LHRH
    Study

    sheepn: not reported in source

    Ovine pituitary cell cultures
    Comparator
    Estradiol
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    10(-6) MAs given in this study (sheep).

    Source sentences

    Summary
    In terms of the LH response to LHRH, Clomid and enclomiphene (10(-6) M) acted as E2 antagonists because they blocked the action of E2 (10(-10) M).
    1 context sentence
    Summary · context
    These responses were used to study the estrogenic and antiestrogenic effects of enclomiphene, zuclomiphene, and their commercial mixture, Clomid.
  2. 02LabIn vitro (cells)Mechanism

    In ovine pituitary cultures, enclomiphene alone did not alter the LH response to LHRH.

    In plain wordsIn cells from sheep, enclomiphene alone did not change the LH response to LHRH.

    Peptide
    Enclomiphene
    Outcome
    No significant changeLH response to LHRH without estradiol
    Study

    sheepn: not reported in source

    Ovine pituitary cell cultures
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    10(-6) MAs given in this study (sheep).

    Source sentences

    Summary
    By themselves they did not alter the LHRH response.
    2 context sentences
    Summary · context
    In terms of the LH response to LHRH, Clomid and enclomiphene (10(-6) M) acted as E2 antagonists because they blocked the action of E2 (10(-10) M).
    Summary · context
    These responses were used to study the estrogenic and antiestrogenic effects of enclomiphene, zuclomiphene, and their commercial mixture, Clomid.
  3. 03LabIn vitro (cells)Mechanism

    In ovine pituitary cultures, enclomiphene blocked estradiol inhibition of FSH secretion.

    In plain wordsIn cells from sheep, enclomiphene prevented estradiol from reducing FSH secretion.

    Peptide
    Enclomiphene
    Outcome
    IncreaseEstradiol inhibition of FSH secretion
    Study

    sheepn: not reported in source

    Ovine pituitary cell cultures
    Comparator
    Estradiol
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    10(-6) MAs given in this study (sheep).

    Source sentences

    Summary
    At a concentration of 10(-6) M, they blocked the inhibitory effects of E2 (10(-10 M) on FSH secretion, but enclomiphene and Clomid also exhibited minor estrogenic action when administered alone.
    1 context sentence
    Summary · context
    These responses were used to study the estrogenic and antiestrogenic effects of enclomiphene, zuclomiphene, and their commercial mixture, Clomid.
  4. 04LabIn vitro (cells)Mechanism

    In ovine pituitary cultures, enclomiphene alone showed minor estrogenic action on FSH secretion.

    In plain wordsIn cells from sheep, enclomiphene alone weakly reduced FSH secretion.

    Peptide
    Enclomiphene
    Outcome
    DecreaseFSH secretion without estradiol
    Study

    sheepn: not reported in source

    Ovine pituitary cell cultures
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    10(-6) MAs given in this study (sheep).

    Source sentences

    Summary
    At a concentration of 10(-6) M, they blocked the inhibitory effects of E2 (10(-10 M) on FSH secretion, but enclomiphene and Clomid also exhibited minor estrogenic action when administered alone.
    2 context sentences
    Summary · context
    17 beta-Estradiol (E2) alters gonadotropin secretions in ovine pituitary cell cultures by 1) augmenting the LH response to LHRH and 2) inhibiting the basal secretion of FSH.
    Summary · context
    These responses were used to study the estrogenic and antiestrogenic effects of enclomiphene, zuclomiphene, and their commercial mixture, Clomid.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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