In lymphocytes from thymectomized guinea pigs, thymosin alpha‑1 at 10-1,000 ng/ml completely restored the ability to produce migration inhibition factor.
In plain wordsIn guinea pig cells, thymosin alpha‑1 fully restored the cells' ability to make a signal molecule (MIF) that thymectomy had removed.
- Peptide
- Thymosin alpha-1
- Outcome
- IncreaseRestoration of migration inhibition factor production
- Study
guinea pign: not reported in source
peripheral blood lymphocytes from thymectomized adult guinea pigs, migration inhibition factor assay- Outcome group
- Immune response · Immune and inflammation
- Studied dose
- 10-1,000 ng/mlAs given in this study (guinea pig).
Measurements
- Concentration
- 10 to 1000 ng/ml
- restoration of MIF production
Source sentences
10-1,000 ng/ml was able to completely restore the MIF-producing capability of PBL from thymectomized guinea pigs.
1 context sentence(design, population, supporting numbers)
Thymosin fraction 5 restored the capacity of peripheral blood lymphocytes (PBL) from thymectomized adult guinea pigs sensitized with purified protein derivative (PPD) to produce migration inhibition factor (MIF) as measured in an agarose droplet microassay with peritoneal exudate cells.