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Study · Animal study (in vivo) · mouse · 1983

4 results

Marked reduction of DNA antibody production and glomerulopathy in thymulin (FTS-Zn) or cyclosporin A treated (NZB X NZW) F1 mice.

Israel-Biet D, Noel LH, Bach MA, Dardenne M, Bach JF

Clinical and experimental immunology1 Nov 1983Cited by 34 (Europe PMC)

PMID6360436 (opens in a new tab)PepBankPUB-06360436
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Summary

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Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In autoimmune mice, thymulin lowered anti-DNA antibodies versus controls, with low levels persisting throughout treatment and seven weeks afterward.

    In plain wordsIn autoimmune mice, thymulin lowered anti-DNA antibodies compared with controls, and levels stayed low after treatment.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseAnti-DNA antibody level
    Study

    mousen: not reported in source

    old (NZB X NZW) F1 male mice with autoimmune disease
    Comparator
    Control mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Compared with control mice, thymulin and Cy A treated mice already showed by 2 weeks a dramatic diminution of their anti-DNA antibody level which remained low throughout the treatment period and persisted for 7 weeks afterwards.
    1 context sentence
    Summary · context
    In this study we have evaluated the action of two compounds, cyclosporin A (Cy A) and thymulin (FTS-Zn) in old (NZB X NZW) F1 male mice which develop severe autoimmune disease.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In autoimmune mice, thymulin reduced glomerular deposits compared with controls.

    In plain wordsIn autoimmune mice, thymulin reduced glomerular deposits compared with controls.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseGlomerular deposits
    Study

    mousen: not reported in source

    old (NZB X NZW) F1 male mice with autoimmune disease
    Comparator
    Control mice
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Glomerular deposits were decreased compared with control mice; these differences were particularly clearcut for IgG1 and IgG2 deposits.
    2 context sentences
    Summary · context
    Renal specimens were studied by direct immunofluorescence in Cy A and thymulin treated mice.
    Summary · context
    In this study we have evaluated the action of two compounds, cyclosporin A (Cy A) and thymulin (FTS-Zn) in old (NZB X NZW) F1 male mice which develop severe autoimmune disease.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In autoimmune mice, thymulin reduced glomerular IgG1 deposits compared with controls.

    In plain wordsIn autoimmune mice, thymulin reduced kidney IgG1 deposits compared with controls.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseGlomerular IgG1 deposits
    Study

    mousen: not reported in source

    old (NZB X NZW) F1 male mice with autoimmune disease
    Comparator
    Control mice
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Glomerular deposits were decreased compared with control mice; these differences were particularly clearcut for IgG1 and IgG2 deposits.
    2 context sentences
    Summary · context
    Renal specimens were studied by direct immunofluorescence in Cy A and thymulin treated mice.
    Summary · context
    In this study we have evaluated the action of two compounds, cyclosporin A (Cy A) and thymulin (FTS-Zn) in old (NZB X NZW) F1 male mice which develop severe autoimmune disease.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In autoimmune mice, thymulin reduced glomerular IgG2 deposits compared with controls.

    In plain wordsIn autoimmune mice, thymulin reduced kidney IgG2 deposits compared with controls.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseGlomerular IgG2 deposits
    Study

    mousen: not reported in source

    old (NZB X NZW) F1 male mice with autoimmune disease
    Comparator
    Control mice
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Glomerular deposits were decreased compared with control mice; these differences were particularly clearcut for IgG1 and IgG2 deposits.
    2 context sentences
    Summary · context
    Renal specimens were studied by direct immunofluorescence in Cy A and thymulin treated mice.
    Summary · context
    In this study we have evaluated the action of two compounds, cyclosporin A (Cy A) and thymulin (FTS-Zn) in old (NZB X NZW) F1 male mice which develop severe autoimmune disease.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:55 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

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