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Study · Ex vivo tissue · rat · 1984

5 results

Stimulatory action of oxytocin on neurones of the dorsal motor nucleus of the vagus nerve.

Charpak S, Armstrong WE, Mühlethaler M, Dreifuss JJ

Brain research1 May 1984Cited by 85 (Europe PMC)

PMID6329430 (opens in a new tab)DOI10.1016/0006-8993(84)91342-8 (opens in a new tab)PepBankPUB-06329430
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueActivity measurement

    In rat brainstem slices, oxytocin at 10(-7) M or 10(-6) M excited 79% of spontaneously active neurones in the dorsal motor nucleus of the vagus, in a concentration-dependent, reversible manner.

    In plain wordsIn lab tests of rat brainstem slices, oxytocin excited most tested cells in the vagus nerve nucleus.

    Peptide
    Oxytocin
    Outcome
    IncreaseExcitation of dorsal motor nucleus of vagus neurones
    Study

    ratn: not reported in source

    brainstem slices, dorsal motor nucleus of the vagus
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    10(-7) M or 10(-6) M · bath applicationAs given in this study (rat).

    Measurements

    Neurones excited
    79%
    dorsal motor nucleus of vagus

    Source sentences

    Summary
    Oxytocin applied to the bath at concentrations of 10(-7) M or 10(-6) M excited 79% of these cells in a concentration-dependent, reversible manner.
    1 context sentence
    Summary · context
    Extracellular recordings were obtained from spontaneously active neurones located in the dorsal motor nucleus of vagus nerve ( DMX ) in slices of the rat brainstem.
  2. 02LabEx vivo tissueActivity measurement

    In rat brainstem slices, the remaining neurones in the dorsal motor nucleus of the vagus were unaffected by oxytocin.

    In plain wordsIn lab tests of rat brainstem slices, some cells in the vagus nerve nucleus did not respond to oxytocin.

    Peptide
    Oxytocin
    Outcome
    No significant changeNeurones unaffected by oxytocin
    Study

    ratn: not reported in source

    brainstem slices, dorsal motor nucleus of the vagus
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    10(-7) M or 10(-6) M · bath applicationAs given in this study (rat).

    Source sentences

    Summary
    The remaining cells were unaffected.
    2 context sentences
    Summary · context
    Oxytocin applied to the bath at concentrations of 10(-7) M or 10(-6) M excited 79% of these cells in a concentration-dependent, reversible manner.
    Summary · context
    Extracellular recordings were obtained from spontaneously active neurones located in the dorsal motor nucleus of vagus nerve ( DMX ) in slices of the rat brainstem.
  3. 03LabEx vivo tissueActivity measurement

    In rat brainstem slices, oxytocin was as potent as a selective oxytocic agonist.

    In plain wordsIn lab tests of rat brainstem slices, oxytocin was as potent as a selective oxytocic agonist.

    Peptide
    Oxytocin
    Outcome
    Not applicablePotency of oxytocin versus selective oxytocic agonist
    Study

    ratn: not reported in source

    brainstem slices, dorsal motor nucleus of the vagus
    Comparator
    selective oxytocic agonist
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    A selective oxytocic agonist was as potent as oxytocin, whereas vasopressin exerted a much weaker effect.
    1 context sentence
    Summary · context
    Extracellular recordings were obtained from spontaneously active neurones located in the dorsal motor nucleus of vagus nerve ( DMX ) in slices of the rat brainstem.
  4. 04LabEx vivo tissueActivity measurement

    In rat brainstem slices, vasopressin exerted a much weaker effect than oxytocin.

    In plain wordsIn lab tests of rat brainstem slices, vasopressin had a much weaker effect than oxytocin.

    Peptide
    Oxytocin
    Outcome
    IncreasePotency of oxytocin versus vasopressin
    Study

    ratn: not reported in source

    brainstem slices, dorsal motor nucleus of the vagus
    Comparator
    vasopressin
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    A selective oxytocic agonist was as potent as oxytocin, whereas vasopressin exerted a much weaker effect.
    1 context sentence
    Summary · context
    Extracellular recordings were obtained from spontaneously active neurones located in the dorsal motor nucleus of vagus nerve ( DMX ) in slices of the rat brainstem.

Studies that did not test the peptide alone1

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 05LabNot a test of Oxytocin aloneEx vivo tissueActivity measurement

    In rat brainstem slices, a structural analogue that blocks peripheral effects of neurohypophysial peptides reversibly antagonized the oxytocin-induced excitation.

    In plain wordsIn lab tests of rat brainstem slices, a blocking compound reversed the excitation caused by oxytocin.

    Peptide
    Oxytocin
    Outcome
    DecreaseAntagonism of oxytocin excitation by a structural analogue
    Study

    ratn: not reported in source

    brainstem slices, dorsal motor nucleus of the vagus
    Outcome group
    Brain and neuronal activity · Nervous system and cognition

    Source sentences

    Summary
    The stimulatory effect of oxytocin was reversibly antagonized by a synthetic structural analogue known to block the peripheral, endocrine effects of neurohypophysial peptides.
    1 context sentence
    Summary · context
    Extracellular recordings were obtained from spontaneously active neurones located in the dorsal motor nucleus of vagus nerve ( DMX ) in slices of the rat brainstem.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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