Structure and comparison of the oxytocin and vasopressin genes from rat.

Ivell R, Richter D

Proceedings of the National Academy of Sciences of the United States of America1 Apr 1984Cited by 196 (Europe PMC)

PMID6326097PMCIDPMC345425DOI10.1073/pnas.81.7.2006PepBankPUB-06326097

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone7

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

01LabNot a test of Oxytocin aloneIn vitro (cell-free)Other
The sequenced rat oxytocin gene was about 850 base pairs long.
In plain wordsIn lab tests, the rat oxytocin gene was about 850 base pairs long.
Peptide
Oxytocin
Outcome
Not applicableSize of the oxytocin gene
Study
ratn: not reported in source
rat genomic library
Outcome group
Peptide structure and chemistry · Endocrine and hormones
Measurements
Gene size
≈ 850 base pairs
rat oxytocin gene
Source sentences
Summary
The small gene (approximately equal to 850 base pairs) predicts a mRNA of approximately equal to 500 bases [without the poly(A) tail].
1 context sentence(design, population, supporting numbers)
Summary · context
The gene encoding the precursor protein to the hormone oxytocin and its associated neurophysin has been isolated from a rat genomic library, and its sequence has been determined.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-0632609701
02LabNot a test of Oxytocin aloneIn vitro (cell-free)Other
The rat oxytocin gene has an exon-intron organization similar to the vasopressin gene, with two splice sites in the protein-coding region.
In plain wordsIn lab tests, the rat oxytocin gene was organized like the vasopressin gene.
Peptide
Oxytocin
Outcome
Not applicableExon-intron organization of the oxytocin gene
Study
ratn: not reported in source
rat genomic library
Outcome group
Peptide structure and chemistry · Endocrine and hormones
Source sentences
Summary
The exon-intron organization is similar to that of the vasopressin gene, with two splice sites in the protein-coding region.
1 context sentence(design, population, supporting numbers)
Summary · context
The gene encoding the precursor protein to the hormone oxytocin and its associated neurophysin has been isolated from a rat genomic library, and its sequence has been determined.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-0632609702
03LabNot a test of Oxytocin aloneIn vitro (cell-free)Other
The first exon of the rat oxytocin gene holds the 5' noncoding promoter region, a putative signal peptide, the oxytocin nonapeptide and the NH2-terminal region of neurophysin.
In plain wordsIn lab tests, the first exon of the rat oxytocin gene included oxytocin and the start of neurophysin.
Peptide
Oxytocin
Outcome
Not applicableExon A content of the oxytocin gene
Study
ratn: not reported in source
rat genomic library
Outcome group
Peptide structure and chemistry · Endocrine and hormones
Source sentences
Summary
The first exon (A) comprises the 5' noncoding promoter region, a putative signal peptide, the nonapeptide hormone oxytocin, and the NH2-terminal, variable region of neurophysin.
1 context sentence(design, population, supporting numbers)
Summary · context
The gene encoding the precursor protein to the hormone oxytocin and its associated neurophysin has been isolated from a rat genomic library, and its sequence has been determined.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-0632609703
04LabNot a test of Oxytocin aloneIn vitro (cell-free)Other
A stretch of 143 nucleotides within exon B of the rat oxytocin gene is entirely homologous, except for one base, to the vasopressin gene, which supports a recent gene conversion event.
In plain wordsIn lab tests, part of the rat oxytocin gene was almost the same as part of the vasopressin gene.
Peptide
Oxytocin
Outcome
Not applicableHomology of oxytocin and vasopressin genes in exon B
Study
ratn: not reported in source
rat genomic library
Outcome group
Peptide structure and chemistry · Endocrine and hormones
Measurements
Homologous stretch
143 nucleotides
exon B
Source sentences
Summary
A stretch of 143 nucleotides within exon B, except for a single base change, is entirely homologous to the equivalent part of the rat vasopressin gene, offering support for a gene conversion event having recently affected the two genes.
1 context sentence(design, population, supporting numbers)
Summary · context
The gene encoding the precursor protein to the hormone oxytocin and its associated neurophysin has been isolated from a rat genomic library, and its sequence has been determined.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-0632609704
05LabNot a test of Oxytocin aloneIn vitro (cell-free)Other
The sequenced rat oxytocin gene predicted an mRNA of about 500 bases without the poly(A) tail.
In plain wordsIn lab tests, sequencing of the rat oxytocin gene predicted an mRNA about 500 bases long.
Peptide
Oxytocin
Outcome
Not applicablePredicted mRNA size of the oxytocin gene
Study
ratn: not reported in source
rat genomic library
Outcome group
Peptide structure and chemistry · Endocrine and hormones
Measurements
Predicted mRNA size
≈ 500 bases
without the poly(A) tail
Source sentences
Summary
The small gene (approximately equal to 850 base pairs) predicts a mRNA of approximately equal to 500 bases [without the poly(A) tail].
1 context sentence(design, population, supporting numbers)
Summary · context
The gene encoding the precursor protein to the hormone oxytocin and its associated neurophysin has been isolated from a rat genomic library, and its sequence has been determined.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-0632609705
06LabNot a test of Oxytocin aloneIn vitro (cell-free)Other
The second exon of the rat oxytocin gene encodes the central, conserved region of neurophysin.
In plain wordsIn lab tests, the second exon of the rat oxytocin gene encoded the central region of neurophysin.
Peptide
Oxytocin
Outcome
Not applicableExon B content of the oxytocin gene
Study
ratn: not reported in source
rat genomic library
Outcome group
Peptide structure and chemistry · Endocrine and hormones
Source sentences
Summary
The second exon (B) encodes the central, conserved region of neurophysin, and the third exon (C) encodes the remaining COOH terminus of neurophysin, with an additional arginine residue at its end, presumably cleaved off during post-translational processing.
1 context sentence(design, population, supporting numbers)
Summary · context
The gene encoding the precursor protein to the hormone oxytocin and its associated neurophysin has been isolated from a rat genomic library, and its sequence has been determined.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-0632609706
07LabNot a test of Oxytocin aloneIn vitro (cell-free)Other
The third exon of the rat oxytocin gene encodes the remaining COOH terminus of neurophysin with an additional arginine residue at its end.
In plain wordsIn lab tests, the third exon of the rat oxytocin gene encoded the remaining end of neurophysin with an extra arginine.
Peptide
Oxytocin
Outcome
Not applicableExon C content of the oxytocin gene
Study
ratn: not reported in source
rat genomic library
Outcome group
Peptide structure and chemistry · Endocrine and hormones
Source sentences
Summary
The second exon (B) encodes the central, conserved region of neurophysin, and the third exon (C) encodes the remaining COOH terminus of neurophysin, with an additional arginine residue at its end, presumably cleaved off during post-translational processing.
1 context sentence(design, population, supporting numbers)
Summary · context
The gene encoding the precursor protein to the hormone oxytocin and its associated neurophysin has been isolated from a rat genomic library, and its sequence has been determined.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-0632609707

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 20:03 UTC
Study results updated
Version 1
9 Oct 2026, 02:53 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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MeSH terms

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