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Study · Ex vivo tissue · 1984

2 results

Specificity of a cytochemical bioassay for arginine-vasopressin and its validation for plasma measurement.

Smith A, McIntosh N

Bioscience reports1 Feb 1984Cited by 5 (Europe PMC)

PMID6324921 (opens in a new tab)DOI10.1007/bf01120306 (opens in a new tab)PepBankPUB-06324921
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueActivity measurement

    In the cytochemical bioassay, oxytocin produced less than 5% of the Na+/K+ ATP-ase activity induced by the same concentration of AVP.

    In plain wordsIn a lab assay on kidney tissue, oxytocin produced less than 5% of the enzyme activity induced by the same concentration of AVP.

    Peptide
    Oxytocin
    Outcome
    Not applicableOxytocin Na+/K+ ATP-ase stimulation relative to AVP
    Study

    n: not reported in source

    cytochemical bioassay of Na+/K+ ATP-ase in loop of Henle tissue
    Comparator
    AVP at the same concentration
    Outcome group
    Receptor activity and mechanism · Kidney and urinary
    Studied dose
    Dose not stated

    Measurements

    Enzyme activity relative to AVP
    < 5%
    oxytocin

    Source sentences

    Summary
    Lysine-vasopressin (LVP), oxytocin (OT), and arginine-vasotocin (AVT) produce less than 5% of the enzyme activity induced by the same concentration of AVP.
    1 context sentence
    Summary · context
    The total Na+/K+ ATP-ase activity of the thick ascending limb of the loop of Henle may be stimulated by arginine-vasopressin (AVP).

Studies that did not test the peptide alone1

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 02LabNot a test of Oxytocin aloneEx vivo tissueActivity measurement

    In the cytochemical bioassay, a mixture of T3, T4, aldosterone, angiotensin II and oxytocin at physiological concentrations did not significantly increase total Na+/K+ ATP-ase activity.

    In plain wordsIn a lab assay on kidney tissue, a mixture of several hormones, oxytocin among them, did not raise the enzyme activity.

    Peptide
    Oxytocin
    Outcome
    No significant changeNa+/K+ ATP-ase activity with a hormone mixture including oxytocin
    Study

    n: not reported in source

    cytochemical bioassay of Na+/K+ ATP-ase in loop of Henle tissue
    Outcome group
    Receptor activity and mechanism · Kidney and urinary

    Source sentences

    Summary
    Physiological concentrations of a mixture of other hormones with known activity on the kidney (T3, T4, aldosterone, angiotensin II, and OT) did not significantly increase total Na+/K+ ATP-ase activity.
    1 context sentence
    Summary · context
    The total Na+/K+ ATP-ase activity of the thick ascending limb of the loop of Henle may be stimulated by arginine-vasopressin (AVP).

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:54 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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