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Study · Ex vivo tissue · brattleboro rat and wistar rat · 1983

2 results

Oxytocin as well as vasopressin potentiate ovine CRF in vitro.

Antoni FA, Holmes MC, Jones MT

Peptides1 Jul 1983Cited by 69 (Europe PMC)

PMID6316291 (opens in a new tab)DOI10.1016/0196-9781(83)90041-4 (opens in a new tab)PepBankPUB-06316291
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueMechanism

    In Wistar rat anterior pituitary segments, oxytocin augmented ovine CRF-induced corticotropin release two- to threefold.

    In plain wordsIn lab tests of Wistar rat pituitary tissue, oxytocin increased CRF-induced corticotropin release two- to threefold.

    Peptide
    Oxytocin
    Outcome
    IncreaseCorticotropin release induced by ovine CRF
    Study

    Wistar ratn: not reported in source

    anterior pituitary gland segments
    Comparator
    Ovine CRF alone
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    0.9-90 mIU/mlAs given in this study (Wistar rat).

    Source sentences

    Summary
    Ovine CRF (0.1-2.5 nmol/l) stimulated corticotropin release by pituitaries of Wistar rats and this effect was augmented two- to threefold in the presence of arginine vasopressin (0.09-0.9 mIU/ml) or oxytocin (0.9-90 mIU/ml).
    1 context sentence
    Summary · context
    Segments of the anterior pituitary glands obtained from male and female Wistar or from female hetero- and homozygous Brattleboro rats were used.
  2. 02LabEx vivo tissueMechanism

    In anterior pituitary segments from female homozygous and heterozygous Brattleboro rats, a similar oxytocin augmentation of ovine CRF-induced corticotropin release was demonstrated.

    In plain wordsIn lab tests of pituitary tissue from female Brattleboro rats, oxytocin similarly increased CRF-induced corticotropin release.

    Peptide
    Oxytocin
    Outcome
    IncreaseOvine CRF-induced corticotropin release in Brattleboro rat pituitary segments
    Study

    Brattleboro ratn: not reported in source

    anterior pituitary gland segments
    Comparator
    Ovine CRF alone
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    0.9-90 mIU/mlAs given in this study (Brattleboro rat).

    Source sentences

    Summary
    A similar phenomenon was demonstrated in Brattleboro rats.
    2 context sentences
    Summary · context
    Segments of the anterior pituitary glands obtained from male and female Wistar or from female hetero- and homozygous Brattleboro rats were used.
    Summary · context
    Ovine CRF (0.1-2.5 nmol/l) stimulated corticotropin release by pituitaries of Wistar rats and this effect was augmented two- to threefold in the presence of arginine vasopressin (0.09-0.9 mIU/ml) or oxytocin (0.9-90 mIU/ml).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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