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Study · Non-randomized trial · 1983

4 results

Responses of plasma renin activity, aldosterone, adrenocorticotropin, and cortisol to dermorphin, a new synthetic potent opiate-like peptide, in man.

Degli Uberti EC, Trasforini G, Salvadori S, Margutti A, Tomatis R, Bianconi M, Rotola C, Pansini R

The Journal of clinical endocrinology and metabolism1 Dec 1983Cited by 15 (Europe PMC)

PMID6313731 (opens in a new tab)DOI10.1210/jcem-57-6-1179 (opens in a new tab)PepBankPUB-06313731
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In normal men, dermorphin significantly increased plasma renin activity.

    In plain wordsIn normal men, dermorphin increased plasma renin activity.

    Peptide
    Dermorphin
    Outcome
    IncreasePlasma renin activity
    Study

    n: not reported in source

    Outcome group
    Hormone levels · Endocrine and hormones
    Studied dose
    5.5 micrograms/kg X min · infusion · 30 minAs given in this study (human).

    Source sentences

    Summary
    D infusion (5.5 micrograms/kg X min for 30 min) significantly increased PRA (P less than 0.01) and decreased PC levels (P less than 0.02).
    1 context sentence
    Summary · context
    This study was designed to investigate the effect of dermorphin (D), a new synthetic potent opiate-like peptide (H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2), on PRA, plasma aldosterone (PA), plasma cortisol (PC), and plasma ACTH levels in normal men.
  2. 02HumanNon-randomized trialEfficacy outcome

    In normal men, dermorphin significantly decreased plasma cortisol.

    In plain wordsIn normal men, dermorphin decreased blood cortisol levels.

    Peptide
    Dermorphin
    Outcome
    DecreasePlasma cortisol
    Study

    n: not reported in source

    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    5.5 micrograms/kg X min · infusion · 30 minAs given in this study (human).

    Source sentences

    Summary
    D infusion (5.5 micrograms/kg X min for 30 min) significantly increased PRA (P less than 0.01) and decreased PC levels (P less than 0.02).
    1 context sentence
    Summary · context
    This study was designed to investigate the effect of dermorphin (D), a new synthetic potent opiate-like peptide (H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2), on PRA, plasma aldosterone (PA), plasma cortisol (PC), and plasma ACTH levels in normal men.
  3. 03HumanNon-randomized trialEfficacy outcome

    In normal men, dermorphin produced a small decrease in ACTH.

    In plain wordsIn normal men, dermorphin slightly decreased ACTH levels.

    Peptide
    Dermorphin
    Outcome
    DecreaseACTH
    Study

    n: not reported in source

    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    5.5 micrograms/kg X min · infusion · 30 minAs given in this study (human).

    Source sentences

    Summary
    D produced a small decrease in ACTH and a small increase in PA.
    1 context sentence
    Summary · context
    This study was designed to investigate the effect of dermorphin (D), a new synthetic potent opiate-like peptide (H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2), on PRA, plasma aldosterone (PA), plasma cortisol (PC), and plasma ACTH levels in normal men.
  4. 04HumanNon-randomized trialEfficacy outcome

    In normal men, dermorphin produced a small increase in plasma aldosterone.

    In plain wordsIn normal men, dermorphin slightly increased blood aldosterone levels.

    Peptide
    Dermorphin
    Outcome
    IncreasePlasma aldosterone
    Study

    n: not reported in source

    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    5.5 micrograms/kg X min · infusion · 30 minAs given in this study (human).

    Source sentences

    Summary
    D produced a small decrease in ACTH and a small increase in PA.
    1 context sentence
    Summary · context
    This study was designed to investigate the effect of dermorphin (D), a new synthetic potent opiate-like peptide (H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2), on PRA, plasma aldosterone (PA), plasma cortisol (PC), and plasma ACTH levels in normal men.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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