Comparison of the effects of two 'sleep' peptides, delta sleep-inducing peptide and arginine-vasotocin, on single neurons in the rat and rabbit brain stem.

Normanton JR, Gent JP

Neuroscience1 Jan 1983Cited by 12 (Europe PMC)

PMID6300725DOI10.1016/0306-4522(83)90029-5PepBankPUB-06300725

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Activity measurement
In rat and rabbit brain stem, DSIP applied by microiontophoresis predominantly excited single neurons.
In plain wordsIn rats and rabbits, DSIP mostly made brain stem nerve cells fire more.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseNeuronal excitation
Study
rat, rabbitn: not reported in source
single neurons in the nucleus reticularis gigantocellularis of the brain stem
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated · microiontophoresisAs given in this study (rat, rabbit).
Source sentences
Summary
Both peptides showed predominantly excitatory actions in both species when applied by microiontophoresis.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of delta sleep-inducing peptide and arginine-vasotocin were assessed on single neurons in the nucleus reticularis gigantocellularis of the brain stem in rats and rabbits.
Report a problemFND-0630072501
02AnimalAnimal study (in vivo)Activity measurement
In the rat brain stem, a small proportion of cells was inhibited by DSIP.
In plain wordsIn rats, DSIP slowed a small share of brain stem nerve cells.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseNeuronal inhibition
Study
ratn: not reported in source
single neurons in the nucleus reticularis gigantocellularis of the brain stem
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated · microiontophoresisAs given in this study (rat).
Source sentences
Summary
A small proportion of cells was inhibited by delta sleep-inducing peptide in the rat.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of delta sleep-inducing peptide and arginine-vasotocin were assessed on single neurons in the nucleus reticularis gigantocellularis of the brain stem in rats and rabbits.
Report a problemFND-0630072502
03AnimalAnimal study (in vivo)Activity measurement
In rat and rabbit brain stem, neuronal responses to DSIP were short-lasting.
In plain wordsIn rats and rabbits, nerve cell responses to DSIP were short-lasting.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
Not applicableTime course of response
Study
rat, rabbitn: not reported in source
single neurons in the nucleus reticularis gigantocellularis of the brain stem
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated · microiontophoresisAs given in this study (rat, rabbit).
Source sentences
Summary
Responses to delta sleep-inducing peptide were short-lasting
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of delta sleep-inducing peptide and arginine-vasotocin were assessed on single neurons in the nucleus reticularis gigantocellularis of the brain stem in rats and rabbits.
Report a problemFND-0630072503
04AnimalAnimal study (in vivo)Activity measurement
In rat and rabbit brain stem, neuronal responses to DSIP were dose-dependent.
In plain wordsIn rats and rabbits, nerve cell responses to DSIP depended on the dose.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
Not applicableDose dependence of response
Study
rat, rabbitn: not reported in source
single neurons in the nucleus reticularis gigantocellularis of the brain stem
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated · microiontophoresisAs given in this study (rat, rabbit).
Source sentences
Summary
Responses to delta sleep-inducing peptide were short-lasting, dose-dependent and showed no significant desensitization to repeated applications.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of delta sleep-inducing peptide and arginine-vasotocin were assessed on single neurons in the nucleus reticularis gigantocellularis of the brain stem in rats and rabbits.
Report a problemFND-0630072504
05AnimalAnimal study (in vivo)Activity measurement
In rat and rabbit brain stem, responses to DSIP showed no significant desensitization to repeated applications.
In plain wordsIn rats and rabbits, nerve cells kept responding to repeated DSIP applications without clear fading.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
No significant changeDesensitization to repeated application
Study
rat, rabbitn: not reported in source
single neurons in the nucleus reticularis gigantocellularis of the brain stem
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated · microiontophoresisAs given in this study (rat, rabbit).
Source sentences
Summary
Responses to delta sleep-inducing peptide were short-lasting, dose-dependent and showed no significant desensitization to repeated applications.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of delta sleep-inducing peptide and arginine-vasotocin were assessed on single neurons in the nucleus reticularis gigantocellularis of the brain stem in rats and rabbits.
Report a problemFND-0630072505
06AnimalAnimal study (in vivo)Activity measurement
In rat and rabbit brain stem, no statistically significant correlation was seen between cells responsive to DSIP and cells responsive to arginine-vasotocin.
In plain wordsIn rats and rabbits, the nerve cells that responded to DSIP were not clearly the same cells that responded to arginine-vasotocin.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
No significant changeOverlap of cells responsive to DSIP and arginine-vasotocin
Study
rat, rabbitn: not reported in source
single neurons in the nucleus reticularis gigantocellularis of the brain stem
Comparator
Arginine-vasotocin
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated · microiontophoresisAs given in this study (rat, rabbit).
Source sentences
Summary
No statistically significant correlation was seen between cells responsive to delta sleep-inducing peptide and those responsive to arginine-vasotocin.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of delta sleep-inducing peptide and arginine-vasotocin were assessed on single neurons in the nucleus reticularis gigantocellularis of the brain stem in rats and rabbits.
Report a problemFND-0630072506

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 18:17 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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MeSH terms

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