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Study · Ex vivo tissue · rat and mouse · 1982

4 results

Effects of PHI on vasoactive intestinal peptide receptors and adenylate cyclase activity in lung membranes. A comparison in man, rat, mouse and guinea pig.

Robberecht P, Tatemoto K, Chatelain P, Waelbroeck M, Delhaye M, Taton G, De Neef P, Camus JC, Heuse D, Christophe J

Regulatory peptides1 Oct 1982Cited by 50 (Europe PMC)

PMID6294750 (opens in a new tab)DOI10.1016/0167-0115(82)90117-3 (opens in a new tab)PepBankPUB-06294750
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueActivity measurement

    In lung membranes from rat, mouse, guinea pig and man, VIP occupying its receptors stimulated adenylate cyclase.

    In plain wordsIn lab tests on lung membranes from rat, mouse, guinea pig and man, VIP switched on the enzyme adenylate cyclase.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    IncreaseAdenylate cyclase stimulation by VIP in lung membranes
    Study

    human, rat, mouse, guinea pign: not reported in source

    lung membranes
    Outcome group
    Receptor activity and mechanism · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The presence of receptors, recognized by vasoactive intestinal peptide (VIP) as well as by PHI (a peptide with N-terminal histidine and C-terminal isoleucine amide), was documented in lung membranes from rat, mouse, guinea pig and man by the ability of these receptors, once occupied, to stimulate adenylate cyclase.
  2. 02LabEx vivo tissueActivity measurement

    In lung membranes from rat, mouse and guinea pig, the capacity of VIP, PHI and secretin to stimulate adenylate cyclase followed the same order as their binding affinity: VIP greater than PHI greater than secretin.

    In plain wordsIn lab tests on animal lung membranes, VIP stimulated the enzyme most strongly, then PHI, then secretin.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    Not applicablePotency of VIP to stimulate adenylate cyclase versus PHI and secretin
    Study

    rat, mouse, guinea pign: not reported in source

    lung membranes
    Comparator
    PHI and secretin
    Outcome group
    Receptor activity and mechanism · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In lung membranes from rat, mouse and guinea pig, the capacity of VIP, PHI and secretin to stimulate the enzyme and the potency of the same peptides to compete with 125I-VIP for binding to VIP receptors were similar, the affinity decreasing in the order: VIP greater than PHI greater than secretin.
  3. 03LabEx vivo tissueActivity measurement

    In lung membranes from rat, mouse and guinea pig, the potency of VIP, PHI and secretin to compete with 125I-VIP for binding to VIP receptors decreased in the order VIP, PHI, secretin.

    In plain wordsIn lab tests on animal lung membranes, VIP competed for the VIP receptor most strongly, then PHI, then secretin.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    Not applicablePotency of VIP to compete with 125I-VIP for binding to VIP receptors
    Study

    rat, mouse, guinea pign: not reported in source

    lung membranes
    Comparator
    PHI and secretin
    Outcome group
    Receptor activity and mechanism · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In lung membranes from rat, mouse and guinea pig, the capacity of VIP, PHI and secretin to stimulate the enzyme and the potency of the same peptides to compete with 125I-VIP for binding to VIP receptors were similar, the affinity decreasing in the order: VIP greater than PHI greater than secretin.
  4. 04LabEx vivo tissueMechanism

    In lung membranes of four species (rat, mouse, guinea pig and man), VIP dose-effect curves were compatible with high-affinity and low-affinity VIP receptors existing together.

    In plain wordsIn lab tests on animal lung membranes, VIP dose-effect curves fitted two kinds of VIP receptor, with high and low affinity.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    Not applicableHigh-affinity and low-affinity VIP receptors
    Study

    human, rat, mouse, guinea pign: not reported in source

    lung membranes
    Outcome group
    Receptor activity and mechanism · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, dose-effect curves were compatible with the coexistence of high-affinity and low-affinity VIP receptors, in the four animal species considered.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:41 UTC

    First added · source update from Europe PMC

Subjects

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