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Study · Ex vivo tissue · rat · 1982

1 result

Characterization of secretin and vasoactive intestinal peptide receptors in rat pancreatic plasma membranes using the native peptides, secretin-(7-27) and five secretin analogues.

Robberecht P, Waelbroeck M, Noyer M, Chatelain P, De Neef P, König W, Christophe J

Digestion1 Jan 1982Cited by 41 (Europe PMC)

PMID6286393 (opens in a new tab)DOI10.1159/000198728 (opens in a new tab)PepBankPUB-06286393
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueMechanism

    In rat pancreatic plasma membranes, adenylate cyclase and binding data allowed VIP-secretin receptors to be classified into VIP-preferring, high-affinity secretin and low-affinity secretin subtypes.

    In plain wordsIn lab tests on rat pancreas membranes, VIP and secretin receptors fell into three types, one of which prefers VIP.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    Not applicableClassification of VIP-secretin receptor subtypes
    Study

    ratn: not reported in source

    pancreatic plasma membranes
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    This allowed a classification of VIP-secretin receptors into three subtypes: (1) VIP-preferring receptors; (2) high-affinity secretin receptors, and (3) low-affinity secretin receptors.
    2 context sentences
    Summary · context
    A comparison has been made of the ability of vasoactive intestinal peptide (VIP), secretin, secretin analogues, and secretin-(7-27) to stimulate adenylate cyclase in rat pancreatic plasma membranes.
    Summary · context
    A parallel study of the capacity of peptides of the VIP-secretin family to compete with 125I-VIP for binding to the same plasma membranes was conducted.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:41 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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