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Study · In vitro (cells) · 1980

7 results

Specific receptors for the serum thymic factor (FTS) in lymphoblastoid cultured cell lines.

Pléau JM, Fuentes V, Morgat JL, Bach JF

Proceedings of the National Academy of Sciences of the United States of America1 May 1980Cited by 30 (Europe PMC)

PMID6248873 (opens in a new tab)PMCIDPMC349505 (opens in a new tab)DOI10.1073/pnas.77.5.2861 (opens in a new tab)PepBankPUB-06248873
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In human T-cell lines, labeled FTS binding reached a steady state within 120 minutes at 30 degrees C.

    In plain wordsIn cells from human T-cell lines, labeled FTS binding reached a steady state within 120 minutes.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    Not applicableBinding steady state
    Study

    humann: not reported in source

    human lymphoblastoid cell lines
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    10 nMAs given in this study (human).

    Measurements

    Time to steady state
    ≤ 120 min
    30 degrees C, 10 nM labeled FTS

    Source sentences

    Summary
    At 30 degrees C, in the presence of 10 nM labeled FTS, a steady state was observed within 120 min.
    1 context sentence
    Summary · context
    The interaction of the synthetic serum thymic factor (FTS, "facteur thymique sérique") with human T lymphocytes from two established T cell lines (1301 and HSB2) was studied by using [3H]FTS.
  2. 02LabIn vitro (cells)Mechanism

    In human T-cell lines, excess unlabeled FTS displaced labeled FTS, with a reported dissociation constant of 3 nM.

    In plain wordsIn cells from human T-cell lines, unlabeled FTS displaced bound labeled FTS.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    Not applicableBinding dissociation constant
    Study

    humann: not reported in source

    human lymphoblastoid cell lines
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Measurements

    Kd
    3 nM
    FTS binding

    Source sentences

    Summary
    Bound labeled FTS was dissociated by simultaneous addition of an excess of unlabeled FTS (dissociation constant Kd = 3 nM).
    1 context sentence
    Summary · context
    The interaction of the synthetic serum thymic factor (FTS, "facteur thymique sérique") with human T lymphocytes from two established T cell lines (1301 and HSB2) was studied by using [3H]FTS.
  3. 03LabIn vitro (cells)Mechanism

    In human T-cell lines, unlabeled FTS reduced labeled FTS binding to 10-20%.

    In plain wordsIn cells from human T-cell lines, unlabeled FTS reduced labeled FTS binding to 10-20%.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseCompetitive binding by unlabeled FTS
    Study

    humann: not reported in source

    human lymphoblastoid cell lines
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    20 microgram/ml (20 micro M)As given in this study (human).

    Measurements

    Residual binding
    10 to 20%
    unlabeled FTS at 20 microgram/ml

    Source sentences

    Summary
    The binding of [3H]FTS was reduced to 10-20% when unlabeled FTS was added at 20 microgram/ml (20 micro M), but not when unrelated peptides or FTS analogues differing from FTS by only one amino acid residue were added.
    1 context sentence
    Summary · context
    The interaction of the synthetic serum thymic factor (FTS, "facteur thymique sérique") with human T lymphocytes from two established T cell lines (1301 and HSB2) was studied by using [3H]FTS.
  4. 04LabIn vitro (cells)Mechanism

    No FTS binding was detectable on B-cell lines.

    In plain wordsIn lab tests, B-cell lines showed no detectable FTS binding.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    Direction not reportedFTS binding in B-cell lines
    Study

    humann: not reported in source

    human lymphoblastoid cell lines
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    No FTS binding was detectable on B and null cell lines or on two T cell lines other than 1301 and HSB2.
    1 context sentence
    Summary · context
    The interaction of the synthetic serum thymic factor (FTS, "facteur thymique sérique") with human T lymphocytes from two established T cell lines (1301 and HSB2) was studied by using [3H]FTS.
  5. 05LabIn vitro (cells)Mechanism

    No FTS binding was detectable on null-cell lines.

    In plain wordsIn lab tests, null-cell lines showed no detectable FTS binding.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    Direction not reportedFTS binding in null-cell lines
    Study

    humann: not reported in source

    human lymphoblastoid cell lines
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    No FTS binding was detectable on B and null cell lines or on two T cell lines other than 1301 and HSB2.
    1 context sentence
    Summary · context
    The interaction of the synthetic serum thymic factor (FTS, "facteur thymique sérique") with human T lymphocytes from two established T cell lines (1301 and HSB2) was studied by using [3H]FTS.
  6. 06LabIn vitro (cells)Mechanism

    No FTS binding was detectable on two T-cell lines other than 1301 and HSB2.

    In plain wordsIn lab tests, two other T-cell lines showed no detectable FTS binding.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    Direction not reportedFTS binding in other T-cell lines
    Study

    humann: not reported in source

    human lymphoblastoid cell lines
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    No FTS binding was detectable on B and null cell lines or on two T cell lines other than 1301 and HSB2.
    1 context sentence
    Summary · context
    The interaction of the synthetic serum thymic factor (FTS, "facteur thymique sérique") with human T lymphocytes from two established T cell lines (1301 and HSB2) was studied by using [3H]FTS.

Studies that did not test the peptide alone1

In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymulin (serum thymic factor).

  1. 07LabNot a test of Thymulin (serum thymic factor) aloneIn vitro (cells)Mechanism

    In human T-cell lines, unrelated peptides or single-residue FTS analogues did not reduce labeled FTS binding.

    In plain wordsIn cells from human T-cell lines, unrelated peptides or FTS analogues did not reduce labeled FTS binding.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changeBinding competition by unrelated peptides or analogues
    Study

    humann: not reported in source

    human lymphoblastoid cell lines
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    The binding of [3H]FTS was reduced to 10-20% when unlabeled FTS was added at 20 microgram/ml (20 micro M), but not when unrelated peptides or FTS analogues differing from FTS by only one amino acid residue were added.
    1 context sentence
    Summary · context
    The interaction of the synthetic serum thymic factor (FTS, "facteur thymique sérique") with human T lymphocytes from two established T cell lines (1301 and HSB2) was studied by using [3H]FTS.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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