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Study · Measured the body's own peptide · 1984

2 results

Inverse correlation between age related abnormalities of T-cell immunity and circulating thymosin alpha 1 levels in haemophilia A.

Kessler CM, Schulof RS, Alabaster O, Goldstein AL, Naylor PH, Phillips TM, Luban NL, Kelleher JF, Reaman GH

British journal of haematology1 Oct 1984Cited by 10 (Europe PMC)

PMID6236839 (opens in a new tab)DOI10.1111/j.1365-2141.1984.tb06091.x (opens in a new tab)PepBankPUB-06236839
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In adult haemophiliacs, higher natural thymosin alpha‑1 levels were associated with lower OKT4/OKT8 ratios.

    In plain wordsIn adults with haemophilia A, higher levels of the body's own thymosin alpha‑1 were linked to a lower T-cell ratio.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableAssociation of serum thymosin alpha 1 with OKT4/OKT8 ratio in adults
    Study

    n = 23

    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    however, regression analysis revealed a significant relationship between elevated thymosin alpha 1 levels and decreased OKT4/OKT8 ratios in adult haemophiliacs (P = 0.012
    2 context sentences
    Summary · context
    In contrast, the mean OKT4/OKT8 ratios of 13 adolescent (1.2 +/- 0.2 SE) and 23 adult (0.8 +/- 0.1 SE) haemophiliacs were significantly reduced.
    Summary · context
    T-cell immunity and serum levels of thymosin alpha 1, beta 2-microglobulin, circulating immune complexes, serum immunoglobulin levels, antibodies to hepatitis surface or core antigen, and to cytomegalovirus, and Epstein-Barr virus were investigated in 51 patients with haemophilia A ranging in age from 2 to 52 years.

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    In patients with haemophilia A, mean serum thymosin alpha‑1 levels in each age category were similar to those of age-matched controls.

    In plain wordsIn people with haemophilia A, the body's own thymosin alpha‑1 levels were similar to those of healthy people of the same age.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeSerum thymosin alpha 1 level compared with age-matched controls
    Study

    n: not reported in source

    Comparator
    Age-matched normal controls
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    The mean serum thymosin alpha 1 levels for each age category was similar to that of age matched controls
    1 context sentence
    Summary · context
    T-cell immunity and serum levels of thymosin alpha 1, beta 2-microglobulin, circulating immune complexes, serum immunoglobulin levels, antibodies to hepatitis surface or core antigen, and to cytomegalovirus, and Epstein-Barr virus were investigated in 51 patients with haemophilia A ranging in age from 2 to 52 years.

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

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