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Study · Animal study (in vivo) · rhesus monkeys · 1984

4 results

Nasal absorption of nafarelin acetate, the decapeptide [D-Nal(2)6)]LHRH, in rhesus monkeys. I.

Anik ST, McRae G, Nerenberg C, Worden A, Foreman J, Hwang JY, Kushinsky S, Jones RE, Vickery B

Journal of pharmaceutical sciences1 May 1984Cited by 32 (Europe PMC)

PMID6234387 (opens in a new tab)DOI10.1002/jps.2600730523 (opens in a new tab)PepBankPUB-06234387
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Pharmacokinetics

    In female rhesus monkeys, intranasal nafarelin absorption was rapid and reproducible, with peak levels at 15-30 min.

    In plain wordsIn rhesus monkeys, intranasal nafarelin reached peak levels at 15-30 min.

    Peptide
    Nafarelin
    Outcome
    Not applicablePeak timing
    Study

    rhesus monkeysn = 6

    female rhesus monkeys
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · intranasalAs given in this study (rhesus monkeys).

    Measurements

    Time to peak
    15 to 30 min
    reported result

    Source sentences

    Summary
    Absorption was rapid and very reproducible, with peak levels occurring at 15-30 min and a bioavailability of approximately 2% relative to a subcutaneous dose.
    1 context sentence
    Summary · context
    Nafarelin acetate, [D-Nal(2)6]LHRH, a highly potent superagonist of luteinizing hormone-releasing hormone, was given intranasally to six female rhesus monkeys.
  2. 02AnimalAnimal study (in vivo)Pharmacokinetics

    In female rhesus monkeys, intranasal nafarelin bioavailability was approximately 2% relative to a subcutaneous dose.

    In plain wordsIn rhesus monkeys, intranasal nafarelin bioavailability was approximately 2% relative to a subcutaneous dose.

    Peptide
    Nafarelin
    Outcome
    Not applicableBioavailability
    Study

    rhesus monkeysn = 6

    female rhesus monkeys
    Comparator
    subcutaneous dose
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · intranasalAs given in this study (rhesus monkeys).

    Measurements

    Bioavailability
    ≈ 2%
    relative to subcutaneous dose

    Source sentences

    Summary
    Absorption was rapid and very reproducible, with peak levels occurring at 15-30 min and a bioavailability of approximately 2% relative to a subcutaneous dose.
    1 context sentence
    Summary · context
    Nafarelin acetate, [D-Nal(2)6]LHRH, a highly potent superagonist of luteinizing hormone-releasing hormone, was given intranasally to six female rhesus monkeys.
  3. 03AnimalAnimal study (in vivo)Pharmacokinetics

    In female rhesus monkeys, the nasal nafarelin dose response was highly nonlinear.

    In plain wordsIn rhesus monkeys, nasal nafarelin dose response was highly nonlinear.

    Peptide
    Nafarelin
    Outcome
    Not applicableNasal dose response
    Study

    rhesus monkeysn = 6

    female rhesus monkeys
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · intranasalAs given in this study (rhesus monkeys).

    Source sentences

    Summary
    The nasal dose response was highly nonlinear.
    1 context sentence
    Summary · context
    Nafarelin acetate, [D-Nal(2)6]LHRH, a highly potent superagonist of luteinizing hormone-releasing hormone, was given intranasally to six female rhesus monkeys.
  4. 04AnimalAnimal study (in vivo)Pharmacokinetics

    In female rhesus monkeys, nafarelin elimination profiles were similar across doses, apparently localizing nonlinearity to absorption.

    In plain wordsIn rhesus monkeys, nafarelin elimination profiles were similar across doses.

    Peptide
    Nafarelin
    Outcome
    No significant changeElimination profiles across doses
    Study

    rhesus monkeysn = 6

    female rhesus monkeys
    Comparator
    other doses
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · intranasalAs given in this study (rhesus monkeys).

    Source sentences

    Summary
    The nonlinearity was apparently associated with the absorption phase, since elimination profiles at all doses were similar.
    1 context sentence
    Summary · context
    Nafarelin acetate, [D-Nal(2)6]LHRH, a highly potent superagonist of luteinizing hormone-releasing hormone, was given intranasally to six female rhesus monkeys.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:36 UTC

    First added · source update from Europe PMC

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