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Study · Animal study (in vivo) · cat · 1983

3 results

Neural vasodilator control in the rectum of the cat and its possible mediation by vasoactive intestinal polypeptide.

Andersson PO, Bloom SR, Edwards AV, Järhult J, Mellander S

The Journal of physiology1 Nov 1983Cited by 24 (Europe PMC)

PMID6197521 (opens in a new tab)DOI10.1113/jphysiol.1983.sp014923 (opens in a new tab)PepBankPUB-06197521
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Activity measurement

    In the anaesthetized cat, intra-arterial VIP infusions caused a rectal vasodilator response that closely resembled that during pelvic nerve stimulation after cholinergic blockade.

    In plain wordsIn cats, VIP infused into the artery widened rectal blood vessels, like nerve stimulation did after blocking acetylcholine.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    IncreaseRectal vasodilator response to VIP infusion
    Study

    catn: not reported in source

    anaesthetized cat rectum and colon
    Outcome group
    Vascular function · Gastrointestinal
    Studied dose
    Dose not stated · intra-arterialAs given in this study (cat).

    Source sentences

    Summary
    Intra-arterial infusions of VIP, which reproduced this rise in rectal venous VIP concentration, caused a rectal vasodilator response which closely resembled that during pelvic nerve stimulation after cholinergic blockade.
    1 context sentence
    Summary · context
    Vascular and motor responses in the rectum to pelvic nerve stimulation are described in the anaesthetized cat and compared with corresponding effects observed in the colon.
  2. 02AnimalAnimal study (in vivo)Activity measurement

    In the anaesthetized cat, the rectal vasculature was estimated to be 50-100 times more sensitive to VIP than the colonic vasculature.

    In plain wordsIn cats, rectal blood vessels were estimated to be 50 to 100 times more sensitive to VIP than colon blood vessels.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    Not applicableSensitivity of rectal versus colonic vasculature to VIP
    Study

    catn: not reported in source

    anaesthetized cat rectum and colon
    Comparator
    Colon vasculature
    Outcome group
    Vascular function · Gastrointestinal
    Studied dose
    Dose not stated

    Measurements

    relative sensitivity to VIP (rectum vs colon)
    50 to 100 fold
    cat rectal vasculature

    Source sentences

    Summary
    The rectal vasculature was estimated to be 50-100 times more sensitive to VIP than the colonic vasculature.
    1 context sentence
    Summary · context
    Vascular and motor responses in the rectum to pelvic nerve stimulation are described in the anaesthetized cat and compared with corresponding effects observed in the colon.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 03AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In the anaesthetized cat, pelvic nerve stimulation caused a substantial release of the animal's own VIP from the rectum, related to the vasodilatation in size and duration.

    In plain wordsIn cats, nerve stimulation made the rectum release much of the body's own VIP, in step with wider blood vessels.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    IncreaseVIP release from the rectum on pelvic nerve stimulation
    Study

    catn: not reported in source

    anaesthetized cat rectum and colon
    Outcome group
    Endogenous peptide levels · Gastrointestinal

    Source sentences

    Summary
    Pelvic nerve stimulation caused a substantial release of vasoactive intestinal polypeptide (VIP) from the rectum, which was related both in magnitude and duration to the vasodilatation.
    1 context sentence
    Summary · context
    Vascular and motor responses in the rectum to pelvic nerve stimulation are described in the anaesthetized cat and compared with corresponding effects observed in the colon.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:41 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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