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Study · Measured the body's own peptide · 1983

4 results

A morphological analysis of vasoactive intestinal polypeptide (VIP)-like immunoreactive neurons in the area dentata of the rat brain.

Köhler C

The Journal of comparative neurology1 Dec 1983Cited by 40 (Europe PMC)

PMID6197428 (opens in a new tab)DOI10.1002/cne.902210302 (opens in a new tab)PepBankPUB-06197428
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In the rat area dentata, VIP-positive cells clustered in or near the granule cell layer, and the deep hilus had almost none.

    In plain wordsIn rats, nerve cells with the body's own VIP clustered near the granule cell layer of the dentate area.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    Not applicableDistribution of VIP-positive neurons in the area dentata
    Study

    ratn: not reported in source

    thick brain sections
    Outcome group
    Endogenous peptide levels · Nervous system and cognition

    Source sentences

    Summary
    The VIP-positive cells are found in all parts of the area dentata, and plots of the distribution of individual cells showed that there is a preferential clustering of these neurons within, or in close proximity to, the granule cell layer, while the deep zones in the hilus are almost completely devoi…
    1 context sentence
    Summary · context
    The general distribution and morphology of vasoactive intestinal polypeptide-like immunoreactive (VIP-LI) neurons in the area dentata (AD) have been studied using immunohistochemical methods on thick (70-120 micron) sections from the rat brain.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In the rat area dentata, the number and relative position of VIP-like immunoreactive neurons stayed rather constant along the long axis.

    In plain wordsIn rats, the number and place of nerve cells with the body's own VIP stayed about the same along the dentate area.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    No significant changeNumber and position of VIP-LI neurons along the long axis
    Study

    ratn: not reported in source

    thick brain sections
    Outcome group
    Endogenous peptide levels · Nervous system and cognition

    Source sentences

    Summary
    Throughout the long axis of the AD the number and relative position of the VIP-LI neurons remains rather constant.
    1 context sentence
    Summary · context
    The general distribution and morphology of vasoactive intestinal polypeptide-like immunoreactive (VIP-LI) neurons in the area dentata (AD) have been studied using immunohistochemical methods on thick (70-120 micron) sections from the rat brain.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

  3. 03AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In the rat area dentata, VIP-positive neurons showed marked variety in size and shape, and small to medium cells predominated.

    In plain wordsIn rats, nerve cells with the body's own VIP varied a lot in size and shape; small and medium cells were most common.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    Not applicableSize and shape of VIP-positive neurons
    Study

    ratn: not reported in source

    thick brain sections
    Outcome group
    Endogenous peptide levels · Nervous system and cognition

    Source sentences

    Summary
    Analysis of the size and shape of the VIP-positive neurons in the AD shows a remarkable morphological heterogeneity, with the soma ranging from small (long axis: approximately 10 micron) ovoid or round, to large (long axis: approximately 25 micron) stellate or multipolar; of these the small to mediu…
    1 context sentence
    Summary · context
    The general distribution and morphology of vasoactive intestinal polypeptide-like immunoreactive (VIP-LI) neurons in the area dentata (AD) have been studied using immunohistochemical methods on thick (70-120 micron) sections from the rat brain.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

  4. 04AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In the rat area dentata, displaced granule cells, granule cells, small ovoid cells and pyramidal basket cells were identified as VIP-positive.

    In plain wordsIn rats, several named types of dentate nerve cells were found to hold the body's own VIP.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    Not applicableIdentified VIP-positive cell types
    Study

    ratn: not reported in source

    thick brain sections
    Outcome group
    Endogenous peptide levels · Nervous system and cognition

    Source sentences

    Summary
    On the basis of this comparison, several displaced granule cells in the molecular layer, as well as granule cells, small ovoid cells, and pyramidal basket cells in the granule cell layer have been identified as VIP-positive as determined by their somatic shape, dendritic branching pattern, and axonal projections.
    1 context sentence
    Summary · context
    The general distribution and morphology of vasoactive intestinal polypeptide-like immunoreactive (VIP-LI) neurons in the area dentata (AD) have been studied using immunohistochemical methods on thick (70-120 micron) sections from the rat brain.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:41 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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